| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Cellular Actions of the Insulin-Like Growth Factor Binding Proteins | Endocrine Reviews | 2002 | 1,609 |
| 3 | Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer | New England Journal of Medicine | 2015 | 1,526 |
| 4 | Cancer-related inflammation and treatment effectiveness | Lancet Oncology, The | 2014 | 1,525 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse | Osteoarthritis and Cartilage | 2010 | 1,151 |
| 7 | Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring | Advances in Wound Care | 2015 | 920 |
| 8 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 836 |
| 9 | HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome | Nature Genetics | 2002 | 686 |
| 10 | Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy | Lancet, The | 2017 | 662 |
| 11 | Are animal models useful for studying human disc disorders/degeneration? | European Spine Journal | 2008 | 611 |
| 12 | Inflammation in Chronic Wounds | International Journal of Molecular Sciences | 2016 | 610 |
| 13 | Biological markers of oxidative stress: Applications to cardiovascular research and practice | Redox Biology | 2013 | 604 |
| 14 | Clinical Presentation and Penetrance of Pheochromocytoma/Paraganglioma Syndromes | Journal of Clinical Endocrinology and Metabolism | 2006 | 560 |
| 15 | Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities | American Journal of Physiology - Endocrinology and Metabolism | 2000 | 491 |
| 16 | DNA Methylation Analysis: Choosing the Right Method | Biology | 2016 | 480 |
| 17 | A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. | British Journal of Clinical Pharmacology | 2015 | 461 |
| 18 | IGF binding proteins in cancer: mechanistic and clinical insights | Nature Reviews Cancer | 2014 | 436 |
| 19 | Osteoarthritis in 2020 and beyond: a Lancet Commission | Lancet, The | 2020 | 355 |
| 20 | Insulin-Like Growth Factor Binding Proteins in the Human Circulation: A Review | Hormone Research | 1994 | 311 |
| 21 | Exosomes: Mechanisms of Uptake | Journal of Circulating Biomarkers | 2015 | 307 |
| 22 | Measuring the global burden of low back pain | Best Practice and Research in Clinical Rheumatology | 2010 | 305 |
| 23 | Substituted ammonium ions as allergenic determinants in drug allergy | Nature | 1983 | 286 |
| 24 | Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma | American Journal of Surgical Pathology | 2014 | 282 |
| 25 | Glucose handling by the kidney | Kidney International | 2011 | 280 |
| 26 | UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas | Cancer Research | 2015 | 270 |
| 27 | Divergent clonal selection dominates medulloblastoma at recurrence | Nature | 2016 | 266 |
| 28 | The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy | Human Molecular Genetics | 2014 | 264 |
| 29 | Genotype‐phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium | Journal of Internal Medicine | 1995 | 263 |
| 30 | Nuclear Import of Insulin-like Growth Factor-binding Protein-3 and -5 Is Mediated by the Importin β Subunit | Journal of Biological Chemistry | 2000 | 252 |
| 31 | Insulin-like Growth Factor-binding Protein (IGFBP)-3 and IGFBP-5 Share a Common Nuclear Transport Pathway in T47D Human Breast Carcinoma Cells | Journal of Biological Chemistry | 1998 | 243 |
| 32 | Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes | Human Pathology | 2010 | 235 |
| 33 | Vandetanib (100 mg) in Patients with Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer | Journal of Clinical Endocrinology and Metabolism | 2010 | 233 |
| 34 | miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer | Clinical Cancer Research | 2009 | 227 |
| 35 | Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells—Renoprotection in Diabetic Nephropathy? | PLoS ONE | 2013 | 224 |
| 36 | A synthesis of existing systematic reviews and meta‐analyses of school‐based behavioural interventions for controlling and preventing obesity | Obesity Reviews | 2012 | 221 |
| 37 | Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons | Journal of Neuroscience | 2016 | 220 |
| 38 | Population-based trends in pregnancy hypertension and pre-eclampsia: an international comparative study | BMJ Open | 2011 | 218 |
| 39 | Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups | Circulation | 2019 | 211 |
| 40 | Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types | American Journal of Surgical Pathology | 2010 | 210 |
| 41 | Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinoma | Clinical Endocrinology | 1996 | 209 |
| 42 | MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer | Oncogene | 2013 | 206 |
| 43 | Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes | Human Molecular Genetics | 2014 | 205 |
| 44 | Driver Fatigue Classification With Independent Component by Entropy Rate Bound Minimization Analysis in an EEG-Based System | IEEE Journal of Biomedical and Health Informatics | 2017 | 205 |
| 45 | A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system | Reproduction | 2011 | 201 |
| 46 | Quality of Data in Perinatal Population Health Databases | Medical Care | 2012 | 197 |
| 47 | The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics | American Journal of Nephrology | 2017 | 194 |
| 48 | Reactivation of Pituitary Hormone Release and Metabolic Improvement by Infusion of Growth Hormone-Releasing Peptide and Thyrotropin-Releasing Hormone in Patients with Protracted Critical Illness1 | Journal of Clinical Endocrinology and Metabolism | 1999 | 191 |
| 49 | Post-traumatic osteoarthritis: from mouse models to clinical trials | Nature Reviews Rheumatology | 2013 | 189 |
| 50 | Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications | Frontiers in Oncology | 2015 | 186 |
