| # | Title | Journal | Year | Citations |
|---|
| 1 | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine | Nature Medicine | 2013 | 661 |
| 2 | Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate | Current Opinion in Structural Biology | 2003 | 653 |
| 3 | Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans | Current Opinion in Structural Biology | 2000 | 384 |
| 4 | Biosynthesis and function of chondroitin sulfate | Biochimica Et Biophysica Acta - General Subjects | 2013 | 354 |
| 5 | Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition | Circulation | 2010 | 326 |
| 6 | Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity | Journal of Neuroscience | 2016 | 323 |
| 7 | Composition of Perineuronal Net Extracellular Matrix in Rat Brain | Journal of Biological Chemistry | 2006 | 311 |
| 8 | Persistent cortical plasticity by upregulation of chondroitin 6-sulfation | Nature Neuroscience | 2012 | 305 |
| 9 | Mechanism of ATP-binding Cassette Transporter A1-mediated Cellular Lipid Efflux to Apolipoprotein A-I and Formation of High Density Lipoprotein Particles | Journal of Biological Chemistry | 2007 | 300 |
| 10 | Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors | Journal of Biological Chemistry | 2002 | 299 |
| 11 | MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects | Pharmaceutical Research | 2001 | 288 |
| 12 | Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme | Nature | 2010 | 272 |
| 13 | Chondroitin/dermatan sulfate in the central nervous system | Current Opinion in Structural Biology | 2007 | 259 |
| 14 | Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans | Nature | 2003 | 252 |
| 15 | Zinc-releasing calcium phosphate for stimulating bone formation | Materials Science and Engineering C | 2002 | 244 |
| 16 | Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients | Kidney International | 2010 | 239 |
| 17 | Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression | Cell | 2008 | 238 |
| 18 | Intercalation of amino acids and peptides into Mg–Al layered double hydroxide by reconstruction method | International Journal of Pharmaceutics | 2004 | 228 |
| 19 | Heparin and Heparan Sulfate Biosynthesis | IUBMB Life | 2002 | 227 |
| 20 | Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension | Circulation: Cardiovascular Quality and Outcomes | 2017 | 227 |
| 21 | Oversulfated Chondroitin/Dermatan Sulfates Containing GlcAβ1/IdoAα1–3GalNAc(4,6-O-disulfate) Interact with L- and P-selectin and Chemokines | Journal of Biological Chemistry | 2002 | 222 |
| 22 | Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice | Journal of Biological Chemistry | 2008 | 222 |
| 23 | Higher radical scavenging activities of polyphenolic antioxidants can be ascribed to chemical reactions following their oxidation | Biochimica Et Biophysica Acta - General Subjects | 2002 | 221 |
| 24 | Mechanism of recipient cell-dependent differences in exosome uptake | BMC Cancer | 2018 | 200 |
| 25 | Microanalysis of Glycosaminoglycan-Derived Oligosaccharides Labeled with a Fluorophore 2-Aminobenzamide by High-Performance Liquid Chromatography: Application to Disaccharide Composition Analysis and Exosequencing of Oligosaccharides | Analytical Biochemistry | 1999 | 196 |
| 26 | Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein | Nature Methods | 2013 | 196 |
| 27 | Molecular Cloning and Expression of a Human Chondroitin Synthase | Journal of Biological Chemistry | 2001 | 184 |
| 28 | The Tumor Suppressor EXT-like Gene EXTL2 Encodes an α1, 4-N-Acetylhexosaminyltransferase That TransfersN-Acetylgalactosamine and N-Acetylglucosamine to the Common Glycosaminoglycan-Protein Linkage Region | Journal of Biological Chemistry | 1999 | 182 |
| 29 | Developmental Regulation of the Sulfation Profile of Chondroitin Sulfate Chains in the Chicken Embryo Brain | Journal of Biological Chemistry | 1997 | 175 |
| 30 | Relationships Among Carbonated Apatite Solubility, Crystallite Size, and Microstrain Parameters | Calcified Tissue International | 1999 | 175 |
| 31 | The DSD-1 Carbohydrate Epitope Depends on Sulfation, Correlates with Chondroitin Sulfate D Motifs, and Is Sufficient to Promote Neurite Outgrowth | Journal of Biological Chemistry | 1998 | 173 |
| 32 | Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia | European Journal of Neuroscience | 2005 | 169 |
| 33 | Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage | International Journal of Molecular Sciences | 2019 | 168 |
| 34 | Molecular Cloning and Expression of Glucuronyltransferase I Involved in the Biosynthesis of the Glycosaminoglycan-Protein Linkage Region of Proteoglycans | Journal of Biological Chemistry | 1998 | 163 |
| 35 | UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice | PLoS ONE | 2011 | 163 |
| 36 | Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 162 |
| 37 | Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease | Journal of Gastroenterology | 2011 | 160 |
| 38 | Chondroitin Sulfate Chains on Syndecan-1 and Syndecan-4 from Normal Murine Mammary Gland Epithelial Cells Are Structurally and Functionally Distinct and Cooperate with Heparan Sulfate Chains to Bind Growth Factors | Journal of Biological Chemistry | 2004 | 155 |
| 39 | Secondary metabolites in plants: transport and self-tolerance mechanisms | Bioscience, Biotechnology and Biochemistry | 2016 | 153 |
| 40 | Antibacterial activity and structure-activity relationships of berberine analogs | European Journal of Medicinal Chemistry | 1996 | 152 |
| 41 | Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization | Journal of Biological Chemistry | 2003 | 150 |
| 42 | Characteristic Hexasaccharide Sequences in Octasaccharides Derived from Shark Cartilage Chondroitin Sulfate D with a Neurite Outgrowth Promoting Activity | Journal of Biological Chemistry | 1998 | 149 |
| 43 | Comprehensive miRNA Expression Analysis in Peripheral Blood Can Diagnose Liver Disease | PLoS ONE | 2012 | 149 |
| 44 | Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium–induced colitis | Inflammatory Bowel Diseases | 2010 | 143 |
| 45 | Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes | Clinica Chimica Acta | 2004 | 141 |
| 46 | Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance | Clinical Biochemistry | 2008 | 138 |
| 47 | Chitosan Induces Apoptosis via Caspase-3 Activation in Bladder Tumor Cells | Japanese Journal of Cancer Research | 2001 | 137 |
| 48 | FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan–protein linkage region | Biochemical Journal | 2009 | 136 |
| 49 | 22-Oxa-1α,25-dihydroxyvitamin D 3 inhibits metastasis and angiogenesis in lung cancer | Carcinogenesis | 2005 | 135 |
| 50 | Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice | Biochemical and Biophysical Research Communications | 2008 | 134 |
