| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | The landscape of somatic copy-number alteration across human cancers | Nature | 2010 | 3,331 |
| 3 | Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 2,191 |
| 4 | Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials | New England Journal of Medicine | 2014 | 1,675 |
| 5 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,671 |
| 6 | The metabolic syndrome in children and adolescents ? an IDF consensus report | Pediatric Diabetes | 2007 | 1,509 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 8 | Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data | BMJ: British Medical Journal | 2017 | 1,408 |
| 9 | Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus | Journal of Diabetes Investigation | 2010 | 1,206 |
| 10 | Continuous renal replacement therapy: A worldwide practice survey | Intensive Care Medicine | 2007 | 1,020 |
| 11 | Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury | Journal of Critical Care | 2009 | 820 |
| 12 | The metabolic syndrome in children and adolescents | Lancet, The | 2007 | 776 |
| 13 | Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination | Nature | 1992 | 767 |
| 14 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Europace | 2018 | 767 |
| 15 | Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren | American Journal of Clinical Nutrition | 2010 | 761 |
| 16 | Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus | Osteoporosis International | 2010 | 736 |
| 17 | Instruction manual for the ILAE 2017 operational classification of seizure types | Epilepsia | 2017 | 699 |
| 18 | Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortex | Neuroscience | 2001 | 616 |
| 19 | Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study | Allergy: European Journal of Allergy and Clinical Immunology | 2015 | 495 |
| 20 | Decreased extra-renal urate excretion is a common cause of hyperuricemia | Nature Communications | 2012 | 489 |
| 21 | p53 mutation in hepatocellular carcinoma after aflatoxin exposure | Lancet, The | 1991 | 436 |
| 22 | Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease | Dementia and Geriatric Cognitive Disorders | 1998 | 419 |
| 23 | CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex | Journal of Cell Biology | 2005 | 409 |
| 24 | Periostin is essential for cardiac healingafter acute myocardial infarction | Journal of Experimental Medicine | 2008 | 404 |
| 25 | Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan | Stroke | 2008 | 404 |
| 26 | The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation | Diabetologia | 2010 | 391 |
| 27 | Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats | Osteoporosis International | 2006 | 384 |
| 28 | Early colorectal carcinoma with special reference to its development de novo | Cancer | 1989 | 377 |
| 29 | Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 375 |
| 30 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary | Europace | 2018 | 375 |
| 31 | Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study | Lancet Oncology, The | 2020 | 364 |
| 32 | Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells | Clinical Cancer Research | 2005 | 361 |
| 33 | Continuous release of endostatin from microencapsulated engineered cells for tumor therapy | Nature Biotechnology | 2001 | 357 |
| 34 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary | Journal of Arrhythmia | 2017 | 348 |
| 35 | Clinical Outcome in Cranioplasty: Critical Review in Long-Term Follow-Up | Journal of Craniofacial Surgery | 2003 | 347 |
| 36 | Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer | Clinical Cancer Research | 2007 | 345 |
| 37 | Identification of Putative Stem Cell Markers, CD133 and CXCR4, in hTERT–Immortalized Primary Nonmalignant and Malignant Tumor-Derived Human Prostate Epithelial Cell Lines and in Prostate Cancer Specimens | Cancer Research | 2007 | 344 |
| 38 | Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion | Journal of the American Society of Nephrology: JASN | 2004 | 340 |
| 39 | Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C | Journal of Gastroenterology | 2004 | 339 |
| 40 | Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population | Science Translational Medicine | 2009 | 334 |
| 41 | Neuroprotective Effects of Edaravone: a Novel Free Radical Scavenger in Cerebrovascular Injury | CNS Neuroscience & Therapeutics | 2006 | 324 |
| 42 | Report of the Committee on the classification and diagnostic criteria of diabetes mellitus | Diabetology International | 2010 | 322 |
| 43 | An Experimental Study on Transpedicular Screw Fixation in Relation to Osteoporosis of the Lumbar Spine | Spine | 1991 | 321 |
| 44 | Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib | Nature Genetics | 2005 | 321 |
| 45 | Ovarian atypical endometriosis: its close association with malignant epithelial tumours | Histopathology | 1997 | 319 |
| 46 | Diabetic Cardiovascular Disease Induced by Oxidative Stress | International Journal of Molecular Sciences | 2015 | 314 |
| 47 | Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population | Nature Genetics | 2012 | 310 |
| 48 | Phospholipase C assay using p-nitrophenylphosphorylcholine together with sorbitol and its application to studying the metal and detergent requirement of the enzyme | Analytical Biochemistry | 1976 | 309 |
| 49 | Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis | Nature Communications | 2019 | 303 |
| 50 | Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials | Lancet Diabetes and Endocrinology,the | 2021 | 292 |
