| # | Title | Journal | Year | Citations |
|---|
| 1 | Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics | Bone Marrow Transplantation | 2013 | 12,312 |
| 2 | Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer | Nature | 2007 | 4,920 |
| 3 | Kyoto global consensus report onHelicobacter pylorigastritis | Gut | 2015 | 1,256 |
| 4 | RET, ROS1 and ALK fusions in lung cancer | Nature Medicine | 2012 | 1,189 |
| 5 | EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors | New England Journal of Medicine | 2010 | 1,124 |
| 6 | European Society of Hypertension Position Paper on Ambulatory Blood Pressure Monitoring | Journal of Hypertension | 2013 | 1,124 |
| 7 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial | Lancet, The | 2008 | 1,091 |
| 8 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019) | Hypertension Research | 2019 | 1,047 |
| 9 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) | Hypertension Research | 2014 | 962 |
| 10 | Common Chronic Pain Conditions in Developed and Developing Countries: Gender and Age Differences and Comorbidity With Depression-Anxiety Disorders | Journal of Pain | 2008 | 918 |
| 11 | Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells | Blood | 2007 | 852 |
| 12 | Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01) | Lancet, The | 2016 | 799 |
| 13 | Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation | New England Journal of Medicine | 2017 | 796 |
| 14 | Oncogenic mutations of ALK kinase in neuroblastoma | Nature | 2008 | 795 |
| 15 | The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland | | 2011 | 780 |
| 16 | Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT | Nature Genetics | 1996 | 773 |
| 17 | European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring | Journal of Hypertension | 2014 | 758 |
| 18 | Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease | Biochemical and Biophysical Research Communications | 1989 | 720 |
| 19 | Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury | Circulation | 2011 | 711 |
| 20 | European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring | Journal of Hypertension | 2008 | 707 |
| 21 | KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer | Clinical Cancer Research | 2009 | 688 |
| 22 | Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis | International Journal of Molecular Sciences | 2016 | 663 |
| 23 | Endoscopic submucosal dissection of early gastric cancer | Journal of Gastroenterology | 2006 | 636 |
| 24 | Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Annals of Neurology | 2008 | 630 |
| 25 | A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas | American Journal of Surgical Pathology | 2015 | 626 |
| 26 | Rivaroxaban vs. Warfarin in Japanese Patients With Atrial Fibrillation | Circulation Journal | 2012 | 589 |
| 27 | Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human | Nature | 2012 | 572 |
| 28 | Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017 | Journal of Atherosclerosis and Thrombosis | 2018 | 541 |
| 29 | Effect of Matching of Class I HLA Alleles on Clinical Outcome after Transplantation of Hematopoietic Stem Cells from an Unrelated Donor | New England Journal of Medicine | 1998 | 534 |
| 30 | Oxytocin-gaze positive loop and the coevolution of human-dog bonds | Science | 2015 | 533 |
| 31 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy | Gastroenterology | 2006 | 512 |
| 32 | Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs | Science | 1992 | 510 |
| 33 | A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer | Nature Medicine | 2012 | 510 |
| 34 | Impact of recombinant soluble thrombomodulin (thrombomodulin alfa) on disseminated intravascular coagulation | Thrombosis Research | 2013 | 506 |
| 35 | Dysregulation of mTOR Signaling in Fragile X Syndrome | Journal of Neuroscience | 2010 | 497 |
| 36 | Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection | Journal of Gastroenterology and Hepatology (Australia) | 2009 | 493 |
| 37 | Dual microglia effects on blood brain barrier permeability induced by systemic inflammation | Nature Communications | 2019 | 492 |
| 38 | A mouse model for EML4-ALK -positive lung cancer | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 490 |
| 39 | Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease | Clinical and Experimental Nephrology | 2007 | 488 |
| 40 | Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts | Clinical Cancer Research | 2008 | 478 |
| 41 | Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial | Lancet Oncology, The | 2019 | 470 |
| 42 | Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation | Journal of Biological Chemistry | 2007 | 463 |
| 43 | Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials | Lancet, The | 2018 | 457 |
| 44 | Epidemiology of Kawasaki Disease in Asia, Europe, and the United States | Journal of Epidemiology | 2012 | 447 |
| 45 | JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ― | Circulation Journal | 2019 | 446 |
| 46 | EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers | Journal of Thoracic Oncology | 2008 | 441 |
| 47 | Randomized, Open-Label, Phase III Study Comparing Irinotecan With Paclitaxel in Patients With Advanced Gastric Cancer Without Severe Peritoneal Metastasis After Failure of Prior Combination Chemotherapy Using Fluoropyrimidine Plus Platinum: WJOG 4007 Trial | Journal of Clinical Oncology | 2013 | 439 |
| 48 | Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome | Nature Genetics | 2012 | 435 |
| 49 | Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes1 | Biology of Reproduction | 2009 | 430 |
| 50 | EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset | Modern Pathology | 2009 | 429 |
