| # | Title | Journal | Year | Citations |
|---|
| 1 | Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial | Lancet, The | 2015 | 1,042 |
| 2 | SARS: Systematic Review of Treatment Effects | PLoS Medicine | 2006 | 994 |
| 3 | Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome | Pain | 2007 | 944 |
| 4 | Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis | Journal of the American College of Cardiology | 2011 | 839 |
| 5 | Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial | Lancet, The | 2016 | 791 |
| 6 | The role of pain and function in determining patient satisfaction after total knee replacement | Journal of Bone and Joint Surgery: British Volume | 2007 | 758 |
| 7 | Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) | Lancet Oncology, The | 2009 | 738 |
| 8 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 9 | European Resuscitation Council Guidelines for Resuscitation 2015 | Resuscitation | 2015 | 696 |
| 10 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in special circumstances: Electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution | Resuscitation | 2010 | 691 |
| 11 | The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy | BMJ: British Medical Journal | 2004 | 498 |
| 12 | Obstetric Anaesthetists' Association and Difficult Airway Society guidelines for the management of difficult and failed tracheal intubation in obstetrics | Anaesthesia | 2015 | 458 |
| 13 | The impact of maternal BMI status on pregnancy outcomes with immediate short‐term obstetric resource implications: a meta‐analysis | Obesity Reviews | 2008 | 444 |
| 14 | Randomized Comparison of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Diabetic Patients | Journal of the American College of Cardiology | 2010 | 421 |
| 15 | Mapping and predicting mortality from systemic sclerosis | Annals of the Rheumatic Diseases | 2017 | 410 |
| 16 | Surgical vs Nonsurgical Treatment of Adults With Displaced Fractures of the Proximal Humerus | JAMA - Journal of the American Medical Association | 2015 | 398 |
| 17 | Endovascular Aortic Repair Versus Open Surgical Repair for Descending Thoracic Aortic Disease | Journal of the American College of Cardiology | 2010 | 396 |
| 18 | The cell biology of bone metabolism | Journal of Clinical Pathology | 2008 | 382 |
| 19 | Detection of Thyroid Dysfunction in Early Pregnancy: Universal Screening or Targeted High-Risk Case Finding? | Journal of Clinical Endocrinology and Metabolism | 2007 | 362 |
| 20 | Outcomes from intensive care in patients with COVID‐19: a systematic review and meta‐analysis of observational studies | Anaesthesia | 2020 | 328 |
| 21 | Anaemia in pregnancy | Best Practice and Research in Clinical Obstetrics and Gynaecology | 2012 | 322 |
| 22 | Variations in mortality after emergency laparotomy: the first report of the UK Emergency Laparotomy Network | British Journal of Anaesthesia | 2012 | 317 |
| 23 | Fetal and Maternal Effects of Phenylephrine and Ephedrine during Spinal Anesthesia for Cesarean Delivery | Anesthesiology | 2002 | 309 |
| 24 | Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years | British Journal of Surgery | 2017 | 304 |
| 25 | Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36 821 women over a 15-year period | BJOG: an International Journal of Obstetrics and Gynaecology | 2007 | 294 |
| 26 | Guideline on antiplatelet and anticoagulation management in cardiac surgery | European Journal of Cardio-thoracic Surgery | 2008 | 280 |
| 27 | Failed tracheal intubation during obstetric general anaesthesia: a literature review | International Journal of Obstetric Anesthesia | 2015 | 274 |
| 28 | Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations | Resuscitation | 2020 | 264 |
| 29 | Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases | Acta Oncológica | 2018 | 256 |
| 30 | Biomechanical testing of the locking compression plate: When does the distance between bone and implant significantly reduce construct stability? | Injury | 2007 | 253 |
| 31 | European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth | Resuscitation | 2021 | 251 |
| 32 | BTS guidelines for the management of malignant pleural effusions | Thorax | 2003 | 248 |
| 33 | Intralesional bleomycin injection (IBI) treatment for haemangiomas and congenital vascular malformations | Pediatric Surgery International | 2004 | 230 |
| 34 | Significant haemoglobinopathies: guidelines for screening and diagnosis | British Journal of Haematology | 2010 | 230 |
| 35 | Long-Term Follow-Up of Elective Chronic Total Coronary Occlusion Angioplasty | Journal of the American College of Cardiology | 2014 | 228 |
| 36 | Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial | PLoS ONE | 2008 | 227 |
| 37 | The effect of post-operative mechanical axis alignment on the survival of primary total knee replacements after a follow-up of 15 years | Journal of Bone and Joint Surgery: British Volume | 2011 | 227 |
| 38 | Corrosion at the neck-stem junction as a cause of metal ion release and pseudotumour formation | Journal of Bone and Joint Surgery: British Volume | 2012 | 216 |
| 39 | The inner nuclear membrane protein Emerin regulates β-catenin activity by restricting its accumulation in the nucleus | EMBO Journal | 2006 | 214 |
| 40 | Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial | Lancet, The | 2015 | 207 |
| 41 | Visualizing the pressure and time burden of intracranial hypertension in adult and paediatric traumatic brain injury | Intensive Care Medicine | 2015 | 203 |
| 42 | Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data | European Journal of Epidemiology | 2019 | 201 |
| 43 | Caring for patients with pain during the COVID‐19 pandemic: consensus recommendations from an international expert panel | Anaesthesia | 2020 | 195 |
| 44 | Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups | Journal of Pediatrics | 2010 | 192 |
| 45 | A Multicenter, Randomized, Controlled Trial of Lucinactant Versus Poractant Alfa Among Very Premature Infants at High Risk for Respiratory Distress Syndrome | Pediatrics | 2005 | 190 |
| 46 | Diabetes- and Nondiabetes-Related Lower Extremity Amputation Incidence Before and After the Introduction of Better Organized Diabetes Foot Care | Diabetes Care | 2008 | 189 |
| 47 | Lamin A/C Is a Risk Biomarker in Colorectal Cancer | PLoS ONE | 2008 | 186 |
| 48 | Quality of life, resource consumption and costs of spinal cord stimulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial) | European Journal of Pain | 2008 | 185 |
| 49 | Aortic valve surgery: Marked increases in volume and significant decreases in mechanical valve use—an analysis of 41,227 patients over 5 years from the Society for Cardiothoracic Surgery in Great Britain and Ireland National database | Journal of Thoracic and Cardiovascular Surgery | 2011 | 185 |
| 50 | Emergency thoracotomy in thoracic trauma—a review | Injury | 2006 | 182 |
