| # | Title | Journal | Year | Citations |
|---|
| 1 | Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses | Nature | 2006 | 3,292 |
| 2 | Cloning of a new cytokine that induces IFN-γ production by T cells | Nature | 1995 | 2,492 |
| 3 | Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product | Journal of Immunology | 1999 | 2,389 |
| 4 | Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C | Nature Genetics | 2009 | 2,124 |
| 5 | Unresponsiveness of MyD88-Deficient Mice to Endotoxin | Immunity | 1999 | 1,906 |
| 6 | Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function | Immunity | 1998 | 1,890 |
| 7 | Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production | Nature | 2008 | 1,837 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 9 | Essential role of Stat6 in IL-4 signalling | Nature | 1996 | 1,425 |
| 10 | Cell Type-Specific Involvement of RIG-I in Antiviral Response | Immunity | 2005 | 1,221 |
| 11 | Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 1,208 |
| 12 | Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer | Journal of Clinical Oncology | 2011 | 1,186 |
| 13 | Interleukin-18 Regulates Both Th1 and Th2 Responses | Annual Review of Immunology | 2001 | 1,180 |
| 14 | Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils | Immunity | 1999 | 1,160 |
| 15 | The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection | Nature Immunology | 2010 | 996 |
| 16 | Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice | Immunity | 1998 | 858 |
| 17 | Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome | Nature Genetics | 1995 | 725 |
| 18 | Benefit of Adjuvant Chemotherapy for Resectable Gastric Cancer | JAMA - Journal of the American Medical Association | 2010 | 711 |
| 19 | Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene | EMBO Journal | 1997 | 680 |
| 20 | Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors | Journal of Comparative Neurology | 2005 | 674 |
| 21 | Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 | Nature Immunology | 2008 | 668 |
| 22 | Activating Transcription Factor 3 (ATF3) Induction by Axotomy in Sensory and Motoneurons: A Novel Neuronal Marker of Nerve Injury | Molecular and Cellular Neurosciences | 2000 | 659 |
| 23 | Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors | Oncogene | 1999 | 625 |
| 24 | Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI | JAMA - Journal of the American Medical Association | 2019 | 602 |
| 25 | A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆ | Gastroenterology | 2004 | 600 |
| 26 | Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu | Cytokine and Growth Factor Reviews | 2001 | 596 |
| 27 | Limb and Skin Abnormalities in Mice Lacking IKK | Science | 1999 | 595 |
| 28 | Hepatocyte growth factor gene therapy of liver cirrhosis in rats | Nature Medicine | 1999 | 583 |
| 29 | SOCS-1 Participates in Negative Regulation of LPS Responses | Immunity | 2002 | 583 |
| 30 | IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production | Journal of Immunology | 1998 | 574 |
| 31 | IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production | Journal of Immunology | 1998 | 567 |
| 32 | Gastrectomy plus chemotherapy versus chemotherapy alone for advanced gastric cancer with a single non-curable factor (REGATTA): a phase 3, randomised controlled trial | Lancet Oncology, The | 2016 | 560 |
| 33 | Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay | Nature | 2009 | 557 |
| 34 | TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury | Journal of Clinical Investigation | 2005 | 542 |
| 35 | Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria | Surgery Today | 2016 | 541 |
| 36 | LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 540 |
| 37 | Mechanisms and functions of Hedgehog signalling across the metazoa | Nature Reviews Genetics | 2011 | 530 |
| 38 | Lapatinib Plus Paclitaxel Versus Paclitaxel Alone in the Second-Line Treatment of HER2-Amplified Advanced Gastric Cancer in Asian Populations: TyTAN—A Randomized, Phase III Study | Journal of Clinical Oncology | 2014 | 524 |
| 39 | JSH Consensus-Based Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma: 2014 Update by the Liver Cancer Study Group of Japan | Liver Cancer | 2014 | 512 |
| 40 | Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice | Journal of Immunology | 1998 | 497 |
| 41 | Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice | Journal of Immunology | 1998 | 483 |
| 42 | Regulation of interferon-γ production by IL-12 and IL-18 | Current Opinion in Immunology | 1998 | 481 |
| 43 | Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells | Nature Immunology | 2009 | 473 |
| 44 | Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria | Hepatology Research | 2016 | 463 |
| 45 | Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis | EMBO Journal | 1999 | 462 |
| 46 | Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system | International Immunology | 2008 | 451 |
| 47 | JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ― | Circulation Journal | 2019 | 446 |
| 48 | Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naïve patients with advanced gastric cancer | Annals of Oncology | 2015 | 417 |
| 49 | Guidelines for the Management ofHelicobacter pyloriInfection in Japan: 2009 Revised Edition | Helicobacter | 2010 | 416 |
| 50 | From The Cover: Dysregulation of TGF- 1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 413 |
