| # | Title | Journal | Year | Citations |
|---|
| 1 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,773 |
| 2 | Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial | Lancet Oncology, The | 2015 | 2,353 |
| 3 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 1,898 |
| 4 | The Biology of Chromatin Remodeling Complexes | Annual Review of Biochemistry | 2009 | 1,891 |
| 5 | Association between telomere length in blood and mortality in people aged 60 years or older | Lancet, The | 2003 | 1,569 |
| 6 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 8 | Olaparib for Metastatic Castration-Resistant Prostate Cancer | New England Journal of Medicine | 2020 | 1,327 |
| 9 | Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2014 | 1,280 |
| 10 | ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes | American Journal of Gastroenterology | 2015 | 1,204 |
| 11 | Distinctive chromatin in human sperm packages genes for embryo development | Nature | 2009 | 1,178 |
| 12 | RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels | Nature | 2007 | 1,104 |
| 13 | A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns | Nature Genetics | 1998 | 1,101 |
| 14 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 15 | Effect of Screening on Ovarian Cancer Mortality | JAMA - Journal of the American Medical Association | 2011 | 1,080 |
| 16 | Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials | Lancet Oncology, The | 2020 | 1,034 |
| 17 | Hereditary and Familial Colon Cancer | Gastroenterology | 2010 | 1,002 |
| 18 | Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma | Nature Medicine | 2019 | 932 |
| 19 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial | Lancet Oncology, The | 2007 | 915 |
| 20 | ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression | Nature | 2006 | 851 |
| 21 | Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes | Nature Medicine | 2011 | 842 |
| 22 | Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes | Nature Reviews Molecular Cell Biology | 2017 | 828 |
| 23 | Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial | Lancet Oncology, The | 2016 | 827 |
| 24 | Cervical cancer: A global health crisis | Cancer | 2017 | 790 |
| 25 | Platelet gene expression and function in patients with COVID-19 | Blood | 2020 | 741 |
| 26 | Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer | Nature Medicine | 2019 | 734 |
| 27 | Post-translational modifications regulate the ticking of the circadian clock | Nature Reviews Molecular Cell Biology | 2007 | 732 |
| 28 | Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A | Cell | 1997 | 705 |
| 29 | Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data | Nature Reviews Cancer | 2019 | 692 |
| 30 | Improving biosensor analysis | Nature Reviews Cancer | 1999 | 678 |
| 31 | Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia | Nature | 2012 | 675 |
| 32 | Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2015 | 633 |
| 33 | Advances in surface plasmon resonance biosensor analysis | Current Opinion in Biotechnology | 2000 | 605 |
| 34 | Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation | Nature Medicine | 2019 | 602 |
| 35 | Exosome-delivered microRNAs modulate the inflammatory response to endotoxin | Nature Communications | 2015 | 601 |
| 36 | LIM-kinase1 Hemizygosity Implicated in Impaired Visuospatial Constructive Cognition | Cell | 1996 | 598 |
| 37 | DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 | Cell | 2008 | 594 |
| 38 | Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells | Cancer Cell | 2012 | 564 |
| 39 | The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 | Oncogene | 2001 | 562 |
| 40 | Mechanical stretch triggers rapid epithelial cell division through Piezo1 | Nature | 2017 | 562 |
| 41 | Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut | Development (Cambridge) | 2005 | 560 |
| 42 | Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study | Lancet Oncology, The | 2020 | 544 |
| 43 | Chromatin remodelling: the industrial revolution of DNA around histones | Nature Reviews Molecular Cell Biology | 2006 | 496 |
| 44 | Pancreatic cancer: from state-of-the-art treatments to promising novel therapies | Nature Reviews Clinical Oncology | 2015 | 489 |
| 45 | Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors | Current Opinion in Biotechnology | 1997 | 478 |
| 46 | Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer | JAMA Oncology | 2017 | 472 |
| 47 | Glioma Subclassifications and Their Clinical Significance | Neurotherapeutics | 2017 | 471 |
| 48 | IDH1 and IDH2 Mutations in Gliomas | Current Neurology and Neuroscience Reports | 2013 | 469 |
| 49 | Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients? | American Society of Clinical Oncology Educational Book / ASCO American Society of Clinical Oncology Meeting | 2019 | 459 |
| 50 | Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers | Nature Medicine | 2019 | 457 |
