| # | Title | Journal | Year | Citations |
|---|
| 1 | Leishmaniasis Worldwide and Global Estimates of Its Incidence | PLoS ONE | 2012 | 4,058 |
| 2 | Primary Prevention of Cardiovascular Disease with a Mediterranean Diet | New England Journal of Medicine | 2013 | 3,677 |
| 3 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 4 | Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions | Cell | 2015 | 1,725 |
| 5 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 6 | Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study | Lancet, The | 2014 | 1,497 |
| 7 | Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study | Lancet, The | 2020 | 1,465 |
| 8 | Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia | New England Journal of Medicine | 2017 | 1,443 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 10 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 11 | Olaparib for Metastatic Castration-Resistant Prostate Cancer | New England Journal of Medicine | 2020 | 1,327 |
| 12 | Patient safety, satisfaction, and quality of hospital care: cross sectional surveys of nurses and patients in 12 countries in Europe and the United States | BMJ: British Medical Journal | 2012 | 1,321 |
| 13 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 14 | Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span | Cell Metabolism | 2008 | 1,060 |
| 15 | The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin | Nature Immunology | 2013 | 1,037 |
| 16 | A Short Screener Is Valid for Assessing Mediterranean Diet Adherence among Older Spanish Men and Women | Journal of Nutrition | 2011 | 973 |
| 17 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 18 | Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline | Clinical Microbiology and Infection | 2018 | 942 |
| 19 | The gut-liver axis in liver disease: Pathophysiological basis for therapy | Journal of Hepatology | 2020 | 935 |
| 20 | 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents | Journal of Hypertension | 2016 | 898 |
| 21 | The global threat of antimicrobial resistance: science for intervention | New Microbes and New Infections | 2015 | 811 |
| 22 | Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML | New England Journal of Medicine | 2019 | 796 |
| 23 | Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial | Lancet Respiratory Medicine,the | 2020 | 789 |
| 24 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 25 | Obesity | Nature Reviews Disease Primers | 2017 | 766 |
| 26 | Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome | Nature Genetics | 2003 | 764 |
| 27 | The Relationship between Leishmaniasis and AIDS: the Second 10 Years | Clinical Microbiology Reviews | 2008 | 754 |
| 28 | Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial | Diabetologia | 2009 | 747 |
| 29 | Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet | Diabetes Care | 2011 | 721 |
| 30 | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 | JAMA Oncology | 2022 | 719 |
| 31 | A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects: The PREDIMED Trial | PLoS ONE | 2012 | 704 |
| 32 | Leishmania and human immunodeficiency virus coinfection: the first 10 years | Clinical Microbiology Reviews | 1997 | 693 |
| 33 | Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain | Science | 2013 | 687 |
| 34 | Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013 | Journal of Hepatology | 2014 | 685 |
| 35 | The global problem of antifungal resistance: prevalence, mechanisms, and management | Lancet Infectious Diseases, The | 2017 | 670 |
| 36 | Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain | British Journal of Nutrition | 2010 | 666 |
| 37 | Mechanisms of Action of Probiotics | Advances in Nutrition | 2019 | 663 |
| 38 | Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling | Cell Host and Microbe | 2016 | 658 |
| 39 | Mediterranean Diet and Age-Related Cognitive Decline | JAMA Internal Medicine | 2015 | 653 |
| 40 | New insights into the multidimensional concept of macrophage ontogeny, activation and function | Nature Immunology | 2016 | 630 |
| 41 | Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism | PLoS Medicine | 2008 | 630 |
| 42 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 43 | Development of the EURO–D scale – a European Union initiative to compare symptoms of depression in 14 European centres | British Journal of Psychiatry | 1999 | 612 |
| 44 | Harmonization of Pulsed-Field Gel Electrophoresis Protocols for Epidemiological Typing of Strains of Methicillin-Resistant Staphylococcus aureus : a Single Approach Developed by Consensus in 10 European Laboratories and Its Application for Tracing the Spread of Related Strains | Journal of Clinical Microbiology | 2003 | 611 |
| 45 | Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study | BMC Medicine | 2013 | 611 |
| 46 | Towards tuberculosis elimination: an action framework for low-incidence countries | European Respiratory Journal | 2015 | 608 |
| 47 | Clinical Relevance of Biomarkers of Oxidative Stress | Antioxidants and Redox Signaling | 2015 | 604 |
| 48 | Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection | Nature Genetics | 2006 | 592 |
| 49 | A review of chronic pain impact on patients, their social environment and the health care system | Journal of Pain Research | 2016 | 569 |
| 50 | A Review of the European Summer Heat Wave of 2003 | Critical Reviews in Environmental Science and Technology | 2010 | 564 |
