| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening | New England Journal of Medicine | 2012 | 763 |
| 3 | Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis | Nature Medicine | 2011 | 750 |
| 4 | Primary Prophylaxis of Spontaneous Bacterial Peritonitis Delays Hepatorenal Syndrome and Improves Survival in Cirrhosis | Gastroenterology | 2007 | 639 |
| 5 | Clinical and Molecular Genetic Spectrum of Congenital Deficiency of the Leptin Receptor | New England Journal of Medicine | 2007 | 610 |
| 6 | Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery | Nature | 2008 | 596 |
| 7 | NEW-ONSET DIABETES AFTER TRANSPLANTATION: 2003 INTERNATIONAL CONSENSUS GUIDELINES1 | Transplantation | 2003 | 547 |
| 8 | Influence of tracheostomy on the incidence of central venous catheter-related bacteremia | European Journal of Clinical Microbiology and Infectious Diseases | 2009 | 543 |
| 9 | Higher Incidence of Catheter-Related Bacteremia in Jugular Site with Tracheostomy than in Femoral Site | Infection Control and Hospital Epidemiology | 2010 | 533 |
| 10 | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci | Nature Genetics | 2010 | 493 |
| 11 | Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools | American Journal of Epidemiology | 2006 | 471 |
| 12 | Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis | Nature Reviews Nephrology | 2016 | 461 |
| 13 | Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study | Blood | 2012 | 429 |
| 14 | Summary of European Association of Urology (EAU) Guidelines on Neuro-Urology | European Urology | 2016 | 406 |
| 15 | Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease | Lancet Diabetes and Endocrinology,the | 2014 | 355 |
| 16 | Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE) | Annals of Oncology | 2010 | 338 |
| 17 | PrimPol, an Archaic Primase/Polymerase Operating in Human Cells | Molecular Cell | 2013 | 322 |
| 18 | Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza | Critical Care | 2009 | 316 |
| 19 | Long-term Controlled Trial of Nocturnal Nasal Positive Pressure Ventilation in Patients With Severe COPD | Chest | 2000 | 312 |
| 20 | A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme | British Journal of Cancer | 2006 | 287 |
| 21 | Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro | Journal of Bone and Mineral Research | 1996 | 287 |
| 22 | RIM-ONE: An open retinal image database for optic nerve evaluation | | 2011 | 282 |
| 23 | Central venous catheter-related infection in a prospective and observational study of 2,595 catheters | Critical Care | 2005 | 257 |
| 24 | Levosimendan: Molecular mechanisms and clinical implications | International Journal of Cardiology | 2012 | 256 |
| 25 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2020 | Endoscopy | 2020 | 255 |
| 26 | Influence of an Endotracheal Tube with Polyurethane Cuff and Subglottic Secretion Drainage on Pneumonia | American Journal of Respiratory and Critical Care Medicine | 2007 | 242 |
| 27 | Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory | Journal of Diabetes Research | 2016 | 238 |
| 28 | Impairment of Health-Related Quality of Life in Patients With Inflammatory Bowel Disease: a Spanish Multicenter Study | Inflammatory Bowel Diseases | 2005 | 236 |
| 29 | Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis | Gastroenterology | 2016 | 232 |
| 30 | Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2012 | 229 |
| 31 | A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicentre Study to Assess the Efficacy and Safety of the β3 Adrenoceptor Agonist, Mirabegron, in Patients With Symptoms of Overactive Bladder | Urology | 2013 | 213 |
| 32 | Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial | Journal of Hepatology | 2003 | 212 |
| 33 | Microbiome and Allergic Diseases | Frontiers in Immunology | 2018 | 211 |
| 34 | Predialysis nephrologic care and a functioning arteriovenous fistula at entry are associated with better survival in incident hemodialysis patients: an observational cohort study | American Journal of Kidney Diseases | 2004 | 209 |
| 35 | Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery | Current Biology | 2006 | 205 |
| 36 | Observation versus antiplatelet therapy as primary prophylaxis for thrombosis in low-risk essential thrombocythemia | Blood | 2010 | 202 |
| 37 | Polymorphisms in GSTT1 , GSTZ1 , and CYP2E1 , Disinfection By-products, and Risk of Bladder Cancer in Spain | Environmental Health Perspectives | 2010 | 194 |
| 38 | Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair | Molecular Cell | 2016 | 193 |
| 39 | First-Line XELOX Plus Bevacizumab Followed by XELOX Plus Bevacizumab or Single-Agent Bevacizumab as Maintenance Therapy in Patients with Metastatic Colorectal Cancer: The Phase III MACRO TTD Study | Oncologist | 2012 | 192 |
| 40 | Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation | Gastroenterology | 2013 | 189 |
| 41 | Genital and urinary tract infections in diabetes: Impact of pharmacologically-induced glucosuria | Diabetes Research and Clinical Practice | 2014 | 189 |
| 42 | CYTOKINE LEVELS (IL-6 AND IFN-γ), ACUTE PHASE RESPONSE AND NUTRITIONAL STATUS AS PROGNOSTIC FACTORS IN LUNG CANCER | Cytokine | 1999 | 188 |
| 43 | Estimated GFR: time for a critical appraisal | Nature Reviews Nephrology | 2019 | 187 |
| 44 | Melatonin and circadian biology in human cardiovascular disease | Journal of Pineal Research | 2010 | 185 |
| 45 | 5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer | Gastroenterology | 2011 | 185 |
| 46 | The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status | European Journal of Cancer | 2009 | 179 |
| 47 | Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma | Journal of Clinical Oncology | 2020 | 175 |
| 48 | Calcium Metabolism and Skeletal Problems after Transplantation | Journal of the American Society of Nephrology: JASN | 2002 | 173 |
| 49 | Meropenem by Continuous Versus Intermittent Infusion in Ventilator-Associated Pneumonia due to Gram-Negative Bacilli | Annals of Pharmacotherapy | 2006 | 168 |
| 50 | Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial | Critical Care | 2007 | 168 |
