| # | Title | Journal | Year | Citations |
|---|
| 1 | Sarcopenia: European consensus on definition and diagnosis | Age and Ageing | 2010 | 9,132 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,060 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors | New England Journal of Medicine | 2017 | 2,206 |
| 6 | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma | Annals of Neurology | 2007 | 2,166 |
| 7 | Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group | Journal of the American Medical Directors Association | 2013 | 1,767 |
| 8 | The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report | Fertility and Sterility | 2009 | 1,639 |
| 9 | Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS) | Age and Ageing | 2014 | 1,462 |
| 10 | Lysergic acid diethylamide- and mescaline-induced attenuation of the effect of punishment in the rat | Science | 1976 | 1,415 |
| 11 | Rosuvastatin in Older Patients with Systolic Heart Failure | New England Journal of Medicine | 2007 | 1,330 |
| 12 | High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung Infection | Science | 2000 | 1,322 |
| 13 | Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,153 |
| 14 | Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group | Clinical Nutrition | 2014 | 1,108 |
| 15 | Classification of the cutaneous manifestations of COVID ‐19: a rapid prospective nationwide consensus study in Spain with 375 cases | British Journal of Dermatology | 2020 | 1,030 |
| 16 | Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database | Annals of the Rheumatic Diseases | 2010 | 1,017 |
| 17 | A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain1 | Journal of Clinical Endocrinology and Metabolism | 2000 | 1,015 |
| 18 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment | Nature Reviews Endocrinology | 2018 | 1,013 |
| 19 | Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation | American Journal of Respiratory and Critical Care Medicine | 2013 | 999 |
| 20 | The CTX-M β-lactamase pandemic | Current Opinion in Microbiology | 2006 | 982 |
| 21 | Chagas disease | Lancet, The | 2018 | 945 |
| 22 | The gut-liver axis in liver disease: Pathophysiological basis for therapy | Journal of Hepatology | 2020 | 935 |
| 23 | The role of the novel adipocyte-derived hormone adiponectin in human disease | European Journal of Endocrinology | 2003 | 909 |
| 24 | European Respiratory Society guidelines for the management of adult bronchiectasis | European Respiratory Journal | 2017 | 788 |
| 25 | CTX-M Enzymes: Origin and Diffusion | Frontiers in Microbiology | 2012 | 707 |
| 26 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 27 | Dissemination of Clonally RelatedEscherichia coliStrains Expressing Extended-Spectrum β-Lactamase CTX-M-15 | Emerging Infectious Diseases | 2008 | 672 |
| 28 | Periodontitis and cardiovascular diseases: Consensus report | Journal of Clinical Periodontology | 2020 | 636 |
| 29 | Defining and combating antibiotic resistance from One Health and Global Health perspectives | Nature Microbiology | 2019 | 614 |
| 30 | Photodynamic therapy of cancer. Basic principles and applications | Clinical and Translational Oncology | 2008 | 611 |
| 31 | Prognosis of child recipients of hematopoietic stem cell transplantation requiring intensive care | Intensive Care Medicine | 2003 | 601 |
| 32 | Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non–Small Cell Lung Cancer | JAMA Oncology | 2018 | 599 |
| 33 | Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis | New England Journal of Medicine | 2012 | 588 |
| 34 | Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations | Annals of Oncology | 2020 | 582 |
| 35 | Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension | JAMA - Journal of the American Medical Association | 2013 | 567 |
| 36 | Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial | Journal of Hepatology | 2016 | 567 |
| 37 | A Deletion Involving the Connexin 30 Gene in Nonsyndromic Hearing Impairment | New England Journal of Medicine | 2002 | 557 |
| 38 | Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure | Hepatology | 2016 | 550 |
| 39 | International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management | Journal of Nutrition, Health and Aging | 2018 | 549 |
| 40 | Circulatory function and hepatorenal syndrome in cirrhosis | Hepatology | 2005 | 537 |
| 41 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial | Lancet, The | 2012 | 517 |
| 42 | Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection | Cell | 2007 | 510 |
| 43 | Sertraline Treatment of Pathological Gambling | Journal of Clinical Psychiatry | 2005 | 510 |
| 44 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 503 |
| 45 | Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study | Age and Ageing | 2013 | 500 |
| 46 | False-negative results of initial RT-PCR assays for COVID-19: A systematic review | PLoS ONE | 2020 | 498 |
| 47 | Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry | Annals of the Rheumatic Diseases | 2021 | 496 |
| 48 | Prevalence and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae in Europe | Clinical Microbiology and Infection | 2008 | 495 |
| 49 | HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality | PLoS Pathogens | 2014 | 495 |
| 50 | Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis | Hepatology | 2015 | 493 |
