| # | Title | Journal | Year | Citations |
|---|
| 1 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 2 | PI3K/Akt signalling pathway and cancer | Cancer Treatment Reviews | 2004 | 1,918 |
| 3 | Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization | Neurology | 2003 | 1,296 |
| 4 | European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines | European Urology | 2021 | 1,152 |
| 5 | Classification of the cutaneous manifestations of COVID ‐19: a rapid prospective nationwide consensus study in Spain with 375 cases | British Journal of Dermatology | 2020 | 1,030 |
| 6 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 7 | Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active‐surveillance report | Arthritis and Rheumatism | 2003 | 889 |
| 8 | Resting Heart Rate in Cardiovascular Disease | Journal of the American College of Cardiology | 2007 | 867 |
| 9 | Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial | Lancet, The | 2019 | 818 |
| 10 | EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries | European Journal of Preventive Cardiology | 2016 | 772 |
| 11 | Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation | BMC Biology | 2012 | 751 |
| 12 | American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials | Annals of the Rheumatic Diseases | 2011 | 657 |
| 13 | Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists | Arthritis and Rheumatism | 2005 | 612 |
| 14 | Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine | European Journal of Heart Failure | 2010 | 593 |
| 15 | Effect of CPAP on Blood Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension | JAMA - Journal of the American Medical Association | 2013 | 567 |
| 16 | Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry | European Journal of Preventive Cardiology | 2019 | 558 |
| 17 | A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex | Cerebral Cortex | 2011 | 543 |
| 18 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 19 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 20 | Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial | European Heart Journal | 2012 | 491 |
| 21 | Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations | Journal of Nutrition, Health and Aging | 2020 | 485 |
| 22 | Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2020 | 475 |
| 23 | Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study | Blood | 2012 | 429 |
| 24 | Acquired Haemophilia: Review and Meta‐Analysis Focused on Therapy and Prognostic Factors | British Journal of Haematology | 2003 | 400 |
| 25 | Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function | Circulation | 2005 | 397 |
| 26 | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study | Lancet, The | 2022 | 392 |
| 27 | Global Alignment and Proportion (GAP) Score | Journal of Bone and Joint Surgery - Series A | 2017 | 360 |
| 28 | EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT | Annals of the Rheumatic Diseases | 2009 | 324 |
| 29 | Clinical Features, Treatment, and Outcome of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A Multinational, Multicenter Study of 362 Patients | Arthritis and Rheumatology | 2014 | 322 |
| 30 | Diversity and Function of Mutations in P450 Oxidoreductase in Patients with Antley-Bixler Syndrome and Disordered Steroidogenesis | American Journal of Human Genetics | 2005 | 321 |
| 31 | Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133) | Journal of Clinical Oncology | 2021 | 317 |
| 32 | Determinants of Underdiagnosis of COPD in National and International Surveys | Chest | 2015 | 316 |
| 33 | Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 316 |
| 34 | A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate | Arthritis and Rheumatism | 2004 | 307 |
| 35 | Specific IgE levels in the diagnosis of immediate hypersensitivity to cows’ milk protein in the infant | Journal of Allergy and Clinical Immunology | 2001 | 303 |
| 36 | Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease | Journal of the American College of Cardiology | 2016 | 303 |
| 37 | Impact on health related quality of life of adult spinal deformity (ASD) compared with other chronic conditions | European Spine Journal | 2015 | 302 |
| 38 | Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy | Journal of Allergy and Clinical Immunology | 2002 | 297 |
| 39 | Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure | European Heart Journal | 2006 | 293 |
| 40 | Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)* | British Journal of Dermatology | 2021 | 289 |
| 41 | High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma | Blood | 2012 | 274 |
| 42 | Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations | Journal of Nutrition, Health and Aging | 2020 | 267 |
| 43 | Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials | Lancet, The | 2019 | 265 |
| 44 | Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients | Journal of Hepatology | 2021 | 261 |
| 45 | The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry | Annals of the Rheumatic Diseases | 2014 | 256 |
| 46 | Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study | Lancet Infectious Diseases, The | 2016 | 256 |
| 47 | PROREPAIR-B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer | Journal of Clinical Oncology | 2019 | 255 |
| 48 | The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease | Gut | 2015 | 254 |
| 49 | A Prospective Randomized Trial of Drug-Eluting Balloons Versus Everolimus-Eluting Stents in Patients With In-Stent Restenosis of Drug-Eluting Stents | Journal of the American College of Cardiology | 2015 | 253 |
| 50 | Abnormalities of the APC/β-catenin pathway in endometrial cancer | Oncogene | 2002 | 252 |
