| # | Title | Journal | Year | Citations |
|---|
| 1 | COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up | Journal of the American College of Cardiology | 2020 | 2,392 |
| 2 | Apixaban in Patients with Atrial Fibrillation | New England Journal of Medicine | 2011 | 2,207 |
| 3 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 4 | Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial | Lancet, The | 2003 | 1,978 |
| 5 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,937 |
| 6 | Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial | Lancet, The | 2011 | 1,759 |
| 7 | Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme | Lancet, The | 2003 | 1,752 |
| 8 | Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure | JAMA - Journal of the American Medical Association | 2009 | 1,694 |
| 9 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,625 |
| 10 | Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease | New England Journal of Medicine | 2006 | 1,536 |
| 11 | Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study | Lancet, The | 2016 | 1,414 |
| 12 | The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice | Gastroenterology | 2011 | 1,380 |
| 13 | Dabigatran versus Warfarin in Patients with Mechanical Heart Valves | New England Journal of Medicine | 2013 | 1,201 |
| 14 | Adverse Impact of Bleeding on Prognosis in Patients With Acute Coronary Syndromes | Circulation | 2006 | 1,196 |
| 15 | Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery | Anesthesiology | 2013 | 1,107 |
| 16 | Pharmacological Treatment of Parkinson Disease | JAMA - Journal of the American Medical Association | 2014 | 1,097 |
| 17 | Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation | Circulation | 2011 | 1,035 |
| 18 | Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials | European Heart Journal | 2000 | 949 |
| 19 | Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: A systematic review and meta-analysis of randomized trials | American Heart Journal | 2009 | 920 |
| 20 | The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study | Lancet, The | 2017 | 838 |
| 21 | American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts | Gastroenterology | 2015 | 816 |
| 22 | Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma | New England Journal of Medicine | 2017 | 810 |
| 23 | Prevention of Atrial Fibrillation With Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers | Journal of the American College of Cardiology | 2005 | 774 |
| 24 | Heparin-Induced Thrombocytopenia: Recognition, Treatment, and Prevention | Chest | 2004 | 766 |
| 25 | Aspirin in Patients Undergoing Noncardiac Surgery | New England Journal of Medicine | 2014 | 735 |
| 26 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial | Lancet, The | 2010 | 725 |
| 27 | Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial | BMJ: British Medical Journal | 2006 | 723 |
| 28 | Routine vs Selective Invasive Strategies in Patients With Acute Coronary Syndromes | JAMA - Journal of the American Medical Association | 2005 | 717 |
| 29 | Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days | New England Journal of Medicine | 2012 | 620 |
| 30 | Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways | Journal of Clinical Investigation | 2001 | 619 |
| 31 | Effect of Glucose-Insulin-Potassium Infusion on Mortality in Patients With Acute ST-Segment Elevation Myocardial Infarction | JAMA - Journal of the American Medical Association | 2005 | 581 |
| 32 | Frailty in Older Adults Undergoing Aortic Valve Replacement | Journal of the American College of Cardiology | 2017 | 561 |
| 33 | Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice | Gastroenterology | 2010 | 553 |
| 34 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 35 | Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme | European Heart Journal | 2008 | 549 |
| 36 | Dronedarone in High-Risk Permanent Atrial Fibrillation | New England Journal of Medicine | 2011 | 547 |
| 37 | Radiofrequency Ablation vs Antiarrhythmic Drugs as First-Line Treatment of Paroxysmal Atrial Fibrillation (RAAFT-2) | JAMA - Journal of the American Medical Association | 2014 | 533 |
| 38 | Influence of Nonfatal Hospitalization for Heart Failure on Subsequent Mortality in Patients With Chronic Heart Failure | Circulation | 2007 | 528 |
| 39 | Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks | JAMA Cardiology | 2018 | 526 |
| 40 | Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer | New England Journal of Medicine | 2017 | 506 |
| 41 | 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure | Canadian Journal of Cardiology | 2017 | 503 |
| 42 | Effects ofCYP2C19Genotype on Outcomes of Clopidogrel Treatment | New England Journal of Medicine | 2010 | 497 |
| 43 | Angelman syndrome 2005: Updated consensus for diagnostic criteria | American Journal of Medical Genetics, Part A | 2006 | 493 |
| 44 | Heparin-induced thrombocytopenia: pathogenesis and management | British Journal of Haematology | 2003 | 492 |
| 45 | Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials | Lancet Diabetes and Endocrinology,the | 2021 | 437 |
| 46 | Effects of Cardiac Autonomic Dysfunction on Mortality Risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial | Diabetes Care | 2010 | 435 |
| 47 | Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis | Annals of Internal Medicine | 2001 | 429 |
| 48 | Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study | Lancet, The | 2020 | 428 |
| 49 | Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia | Nature Genetics | 2010 | 414 |
| 50 | F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction and Suspected Coronary Disease | Journal of the American College of Cardiology | 2007 | 403 |
