| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study | Lancet, The | 2004 | 9,716 |
| 2 | Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients | New England Journal of Medicine | 2000 | 8,226 |
| 3 | Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients | New England Journal of Medicine | 2000 | 1,845 |
| 4 | Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease | New England Journal of Medicine | 2006 | 1,536 |
| 5 | Canadian atrial fibrillation anticoaguiation (CAFA) study | Journal of the American College of Cardiology | 1991 | 1,128 |
| 6 | Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes | New England Journal of Medicine | 2006 | 1,104 |
| 7 | A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease | Archives of Internal Medicine | 2009 | 1,034 |
| 8 | Transcatheter Aortic Valve Implantation for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at Very High or Prohibitive Surgical Risk | Journal of the American College of Cardiology | 2010 | 929 |
| 9 | Effects of Fondaparinux on Mortality and Reinfarction in Patients With Acute ST-Segment Elevation Myocardial Infarction: The OASIS-6 Randomized Trial | JAMA - Journal of the American Medical Association | 2006 | 830 |
| 10 | The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis | British Journal of Radiology | 2012 | 586 |
| 11 | Association of Diet, Exercise, and Smoking Modification With Risk of Early Cardiovascular Events After Acute Coronary Syndromes | Circulation | 2010 | 556 |
| 12 | Epigenomic alterations define lethal CIMP-positive ependymomas of infancy | Nature | 2014 | 521 |
| 13 | Ramipril and the Development of Diabetes | JAMA - Journal of the American Medical Association | 2001 | 487 |
| 14 | Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events | JAMA - Journal of the American Medical Association | 2011 | 471 |
| 15 | Interventions for helping patients to follow prescriptions for medications | The Cochrane Library | 2002 | 440 |
| 16 | Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis | Annals of Internal Medicine | 2001 | 429 |
| 17 | Peroxisome Proliferator-Activated Receptor γ and Adipose Tissue—Understanding Obesity-Related Changes in Regulation of Lipid and Glucose Metabolism | Journal of Clinical Endocrinology and Metabolism | 2007 | 423 |
| 18 | The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis | Journal of the American College of Cardiology | 2002 | 412 |
| 19 | 2014 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation | Canadian Journal of Cardiology | 2014 | 382 |
| 20 | Novel therapeutic concepts * The epidemic of cardiovascular disease in the developing world: global implications | European Heart Journal | 2010 | 366 |
| 21 | Using and understanding sedation scoring systems: a systematic review | Intensive Care Medicine | 2000 | 345 |
| 22 | Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study | Lancet, The | 2003 | 340 |
| 23 | Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study | BMJ: British Medical Journal | 1998 | 338 |
| 24 | Transradial Approach for Coronary Angiography and Interventions | JACC: Cardiovascular Interventions | 2010 | 335 |
| 25 | Variability in the Assessment of Fracture-Healing in Orthopaedic Trauma Studies | Journal of Bone and Joint Surgery - Series A | 2008 | 320 |
| 26 | Proteomic analysis of plasma from Holstein cows testing positive for mycobacterium avium subsp. Paratuberculosis (MAP) | Veterinary Immunology and Immunopathology | 2012 | 289 |
| 27 | Enteral nutrition in the critically ill patient | Critical Care Medicine | 1995 | 286 |
| 28 | Long-Term Outcomes After Transcatheter Aortic Valve Implantation | Journal of the American College of Cardiology | 2012 | 283 |
| 29 | RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT | Lancet, The | 1988 | 282 |
| 30 | Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes | European Heart Journal | 2019 | 275 |
| 31 | Tinzaparin in acute ischaemic stroke (TAIST): a randomised aspirin-controlled trial | Lancet, The | 2001 | 261 |
| 32 | Risk factors for acute myocardial infarction in Indians: a case-control study | Lancet, The | 1996 | 246 |
| 33 | Role of Angiotensin Converting Enzyme Inhibitors in Patients with Left Ventricular Dysfunction and Congestive Heart Failure | European Heart Journal | 1994 | 236 |
| 34 | Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk | Circulation | 2020 | 232 |
| 35 | Radial Artery and Saphenous Vein Patency More Than 5 Years After Coronary Artery Bypass Surgery | Journal of the American College of Cardiology | 2012 | 229 |
| 36 | Increased winter mortality from acute myocardial infarction and stroke: the effect of age | Journal of the American College of Cardiology | 1999 | 226 |
| 37 | Blood-pressure reduction and cardiovascular risk in HOPE study | Lancet, The | 2001 | 220 |
| 38 | Beyond Unfractionated Heparin and Warfarin | Circulation | 2007 | 202 |
| 39 | The consent form as a possible cause of side effects | Clinical Pharmacology and Therapeutics | 1987 | 197 |
| 40 | Anterior Transposition Compared with Simple Decompression for Treatment of Cubital Tunnel Syndrome | Journal of Bone and Joint Surgery - Series A | 2007 | 190 |
| 41 | Regulation of 11β‐HSD Genes in Human Adipose Tissue: Influence of Central Obesity and Weight Loss | Obesity | 2004 | 189 |
| 42 | Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM | European Journal of Heart Failure | 2007 | 188 |
| 43 | Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study | Journal of the American College of Cardiology | 2001 | 183 |
| 44 | Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism | Annual Review of Medicine | 2011 | 177 |
| 45 | Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography | Journal of Thrombosis and Haemostasis | 2005 | 166 |
| 46 | Effects of exercise training in patients with congestive heart failure: A critical review | Journal of the American College of Cardiology | 1995 | 165 |
| 47 | Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials | BMJ: British Medical Journal | 1996 | 165 |
| 48 | Improved Outcomes With Early Collaborative Care of Ambulatory Heart Failure Patients Discharged From the Emergency Department | Circulation | 2010 | 159 |
| 49 | Canadian clinical practice guidelines for acute and chronic rhinosinusitis | Allergy, Asthma and Clinical Immunology | 2011 | 153 |
| 50 | Relationship Between Healthy Diet and Risk of Cardiovascular Disease Among Patients on Drug Therapies for Secondary Prevention | Circulation | 2012 | 151 |
