| # | Title | Journal | Year | Citations |
|---|
| 1 | Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial | Lancet, The | 2009 | 3,965 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 3 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 4 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 5 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 6 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 7 | Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial | Lancet, The | 2012 | 1,849 |
| 8 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 9 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 10 | Cluster Analysis and Clinical Asthma Phenotypes | American Journal of Respiratory and Critical Care Medicine | 2008 | 1,727 |
| 11 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 12 | Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma | New England Journal of Medicine | 2009 | 1,672 |
| 13 | Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial | Lancet, The | 2002 | 1,598 |
| 14 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 15 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 16 | Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution | Nature | 2017 | 1,287 |
| 17 | Common variants near MC4R are associated with fat mass, weight and risk of obesity | Nature Genetics | 2008 | 1,179 |
| 18 | Development of a shuttle walking test of disability in patients with chronic airways obstruction. | Thorax | 1992 | 1,152 |
| 19 | Genome-wide association study identifies eight loci associated with blood pressure | Nature Genetics | 2009 | 1,104 |
| 20 | Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome | Journal of Allergy and Clinical Immunology | 2011 | 1,007 |
| 21 | Human metabolic individuality in biomedical and pharmaceutical research | Nature | 2011 | 916 |
| 22 | The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke | Nature Genetics | 2004 | 859 |
| 23 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 24 | Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma | New England Journal of Medicine | 2006 | 783 |
| 25 | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility | Nature Genetics | 2011 | 778 |
| 26 | Common variants associated with plasma triglycerides and risk for coronary artery disease | Nature Genetics | 2013 | 754 |
| 27 | Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) | Thorax | 2003 | 752 |
| 28 | Genome-wide association analysis identifies 20 loci that influence adult height | Nature Genetics | 2008 | 742 |
| 29 | Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1) | JAMA - Journal of the American Medical Association | 2011 | 729 |
| 30 | British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary | BMJ: British Medical Journal | 2004 | 713 |
| 31 | Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids | Thorax | 2002 | 711 |
| 32 | Genome-wide association analyses identify 18 new loci associated with serum urate concentrations | Nature Genetics | 2013 | 675 |
| 33 | Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease | Journal of the American College of Cardiology | 2015 | 662 |
| 34 | Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma | American Journal of Respiratory and Critical Care Medicine | 2010 | 650 |
| 35 | Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior | Nature Genetics | 2010 | 649 |
| 36 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 631 |
| 37 | Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study | Lancet Oncology, The | 2011 | 612 |
| 38 | Meta-analysis and imputation refines the association of 15q25 with smoking quantity | Nature Genetics | 2010 | 581 |
| 39 | Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction | Nature | 2015 | 581 |
| 40 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 41 | Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations | PLoS Genetics | 2009 | 572 |
| 42 | Thorax: the Cappuccino years | Thorax | 2013 | 570 |
| 43 | Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients | Journal of Allergy and Clinical Immunology | 2012 | 546 |
| 44 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 45 | Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease | New England Journal of Medicine | 2016 | 526 |
| 46 | Prevalence, pathogenesis, and causes of chronic cough | Lancet, The | 2008 | 524 |
| 47 | Genome-wide association study identifies five loci associated with lung function | Nature Genetics | 2010 | 518 |
| 48 | Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial | Lancet, The | 2000 | 514 |
| 49 | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk | Nature Genetics | 2017 | 492 |
| 50 | A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium | Nature Genetics | 2009 | 481 |
