| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Landscape of transcription in human cells | Nature | 2012 | 4,484 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 4 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 5 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 6 | Normal gut microbiota modulates brain development and behavior | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 2,611 |
| 7 | Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells | Cell | 2008 | 2,279 |
| 8 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 2,165 |
| 9 | The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells | Nature Genetics | 2006 | 2,162 |
| 10 | Fast and accurate de novo genome assembly from long uncorrected reads | Genome Research | 2017 | 2,071 |
| 11 | SIFT web server: predicting effects of amino acid substitutions on proteins | Nucleic Acids Research | 2012 | 1,838 |
| 12 | A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes | Cell | 2006 | 1,827 |
| 13 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 14 | Comprehensive Characterization of Cancer Driver Genes and Mutations | Cell | 2018 | 1,670 |
| 15 | An oestrogen-receptor-α-bound human chromatin interactome | Nature | 2009 | 1,537 |
| 16 | MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation | Nature | 2008 | 1,288 |
| 17 | Genome-wide analysis of mammalian promoter architecture and evolution | Nature Genetics | 2006 | 1,201 |
| 18 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 19 | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics | 2010 | 1,132 |
| 20 | An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 1,109 |
| 21 | Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation | Cell | 2012 | 1,096 |
| 22 | LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets | Nucleic Acids Research | 2012 | 1,074 |
| 23 | A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome | Cell | 2006 | 1,060 |
| 24 | SIFT missense predictions for genomes | Nature Protocols | 2016 | 1,053 |
| 25 | Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer | Science | 2008 | 995 |
| 26 | The nf-core framework for community-curated bioinformatics pipelines | Nature Biotechnology | 2020 | 963 |
| 27 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 28 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 29 | Transcriptional Regulation of Nanog by OCT4 and SOX2 | Journal of Biological Chemistry | 2005 | 942 |
| 30 | Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus | Nature Genetics | 2009 | 868 |
| 31 | Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors | Nature Genetics | 2017 | 849 |
| 32 | Functional metagenomic profiling of nine biomes | Nature | 2008 | 842 |
| 33 | The draft genome of sweet orange (Citrus sinensis) | Nature Genetics | 2013 | 837 |
| 34 | Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells | Genes and Development | 2007 | 804 |
| 35 | Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma | Nature Genetics | 2012 | 785 |
| 36 | A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers | PLoS Biology | 2010 | 762 |
| 37 | Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst | Developmental Cell | 2010 | 753 |
| 38 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 39 | Transposable elements have rewired the core regulatory network of human embryonic stem cells | Nature Genetics | 2010 | 698 |
| 40 | A core Klf circuitry regulates self-renewal of embryonic stem cells | Nature Cell Biology | 2008 | 678 |
| 41 | Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts | Breast Cancer Research | 2005 | 659 |
| 42 | Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells | Nature Genetics | 2010 | 652 |
| 43 | Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software | Nature Methods | 2017 | 635 |
| 44 | Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons | Cell Stem Cell | 2016 | 628 |
| 45 | Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer | Cancer Research | 2006 | 606 |
| 46 | Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells | Molecular and Cellular Biology | 2005 | 599 |
| 47 | Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis | Cell | 2012 | 593 |
| 48 | A common coding variant in CASP8 is associated with breast cancer risk | Nature Genetics | 2007 | 591 |
| 49 | RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses | PLoS Biology | 2005 | 589 |
| 50 | Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly | Nature Biotechnology | 2012 | 586 |
