| # | Title | Journal | Year | Citations |
|---|
| 1 | 2007 Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 4,778 |
| 2 | 2013 ESH/ESC Guidelines for the management of arterial hypertension | Journal of Hypertension | 2013 | 4,251 |
| 3 | Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial | Lancet, The | 2018 | 3,542 |
| 4 | Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer | New England Journal of Medicine | 2004 | 2,704 |
| 5 | Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation | New England Journal of Medicine | 2017 | 2,256 |
| 6 | Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer | New England Journal of Medicine | 2013 | 1,971 |
| 7 | Alectinib versus Crizotinib in Untreated ALK-Positive Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2017 | 1,858 |
| 8 | Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501) | Head and Neck | 2005 | 1,412 |
| 9 | Lenalidomide plus Dexamethasone for Relapsed or Refractory Multiple Myeloma | New England Journal of Medicine | 2007 | 1,365 |
| 10 | Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2015 | 1,261 |
| 11 | Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2019 | 1,241 |
| 12 | Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document | Journal of Hypertension | 2009 | 1,236 |
| 13 | Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2010 | 1,220 |
| 14 | European Hernia Society guidelines on the treatment of inguinal hernia in adult patients | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2009 | 1,215 |
| 15 | Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2015 | 1,168 |
| 16 | 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 1,152 |
| 17 | Classification of primary and incisional abdominal wall hernias | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2009 | 915 |
| 18 | 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) | Annals of Oncology | 2018 | 891 |
| 19 | 3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) | Annals of Oncology | 2017 | 865 |
| 20 | De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 | Annals of Oncology | 2017 | 844 |
| 21 | Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? | Frontiers in Immunology | 2017 | 831 |
| 22 | BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity | Cellular and Molecular Neurobiology | 2018 | 823 |
| 23 | Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer | New England Journal of Medicine | 2021 | 764 |
| 24 | Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial | Lancet Oncology, The | 2015 | 762 |
| 25 | 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) | Annals of Oncology | 2020 | 761 |
| 26 | Regulation of protein kinase cascades by protein phosphatase 2A | Trends in Biochemical Sciences | 1999 | 759 |
| 27 | Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2018 | 648 |
| 28 | GATA3 | American Journal of Surgical Pathology | 2014 | 586 |
| 29 | First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells | Clinical Immunology | 2009 | 567 |
| 30 | 2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension | Blood Pressure | 2014 | 565 |
| 31 | Comprehensive review of antimicrobial activities of plant flavonoids | Phytochemistry Reviews | 2019 | 532 |
| 32 | Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial | Lancet Oncology, The | 2022 | 526 |
| 33 | Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal | International Archives of Allergy and Immunology | 2012 | 513 |
| 34 | OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer | Annals of Oncology | 2019 | 493 |
| 35 | Aging, frailty and age-related diseases | Biogerontology | 2010 | 489 |
| 36 | Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines | Cancer Research | 2006 | 482 |
| 37 | Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants | Gastroenterology | 2005 | 473 |
| 38 | Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression | JAMA Psychiatry | 2019 | 472 |
| 39 | Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer | Annals of Oncology | 2014 | 462 |
| 40 | European Hernia Society guidelines on the closure of abdominal wall incisions | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2015 | 460 |
| 41 | A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo | Science Translational Medicine | 2015 | 436 |
| 42 | European position statement on lung cancer screening | Lancet Oncology, The | 2017 | 428 |
| 43 | Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea | Hypertension | 2011 | 427 |
| 44 | QSRR: Quantitative Structure-(Chromatographic) Retention Relationships | Chemical Reviews | 2007 | 423 |
| 45 | Potential Health Benefits of Olive Oil and Plant Polyphenols | International Journal of Molecular Sciences | 2018 | 421 |
| 46 | ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2) | Annals of Oncology | 2014 | 402 |
| 47 | Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2012 | 400 |
| 48 | Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2013 | 400 |
| 49 | Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome | Leukemia | 2019 | 396 |
| 50 | Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer – Results from two randomised studies | European Journal of Cancer | 2010 | 395 |
