| # | Title | Journal | Year | Citations |
|---|
| 1 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data | Bioinformatics | 2010 | 32,955 |
| 2 | A scaling normalization method for differential expression analysis of RNA-seq data | Genome Biology | 2010 | 6,234 |
| 3 | Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 | Nature | 1998 | 3,333 |
| 4 | Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 | Nature | 2009 | 2,534 |
| 5 | Whole genomes redefine the mutational landscape of pancreatic cancer | Nature | 2015 | 2,132 |
| 6 | Gut hormone PYY3-36 physiologically inhibits food intake | Nature | 2002 | 2,039 |
| 7 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 8 | Prediction of bone density from vitamin D receptor alleles | Nature | 1994 | 1,836 |
| 9 | Mortality after all major types of osteoporotic fracture in men and women: an observational study | Lancet, The | 1999 | 1,684 |
| 10 | Endogenous microRNA sponges: evidence and controversy | Nature Reviews Genetics | 2016 | 1,669 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 12 | Mortality Risk Associated With Low-Trauma Osteoporotic Fracture and Subsequent Fracture in Men and Women | JAMA - Journal of the American Medical Association | 2009 | 1,335 |
| 13 | Structure and function of long noncoding RNAs in epigenetic regulation | Nature Structural and Molecular Biology | 2013 | 1,325 |
| 14 | Body mass index as a predictor of fracture risk: A meta-analysis | Osteoporosis International | 2005 | 1,292 |
| 15 | The role of interleukin-2 during homeostasis and activation of the immune system | Nature Reviews Immunology | 2012 | 1,274 |
| 16 | Global vitamin D status and determinants of hypovitaminosis D | Osteoporosis International | 2009 | 1,255 |
| 17 | Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring | Nature | 2010 | 1,214 |
| 18 | Predictive Value of BMD for Hip and Other Fractures | Journal of Bone and Mineral Research | 2005 | 1,213 |
| 19 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 20 | Recovering Gene Interactions from Single-Cell Data Using Data Diffusion | Cell | 2018 | 1,197 |
| 21 | Cyclin D as a therapeutic target in cancer | Nature Reviews Cancer | 2011 | 1,159 |
| 22 | The rise of regulatory RNA | Nature Reviews Genetics | 2014 | 1,120 |
| 23 | Biological determinants of endocrine resistance in breast cancer | Nature Reviews Cancer | 2009 | 1,113 |
| 24 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 25 | Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance | Lancet, The | 1998 | 1,072 |
| 26 | A meta-analysis of previous fracture and subsequent fracture risk | Bone | 2004 | 1,052 |
| 27 | Diet, gut microbiota and immune responses | Nature Immunology | 2011 | 1,050 |
| 28 | The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment | Immunity | 2009 | 1,041 |
| 29 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 30 | The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women | Osteoporosis International | 2007 | 1,017 |
| 31 | Regulated transport of the glucose transporter GLUT4 | Nature Reviews Molecular Cell Biology | 2002 | 1,008 |
| 32 | IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis | Cell | 2007 | 993 |
| 33 | The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses | Annual Review of Immunology | 2000 | 969 |
| 34 | Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States | Diabetes | 2006 | 932 |
| 35 | Beyond insulin resistance in NASH: TNF-? or adiponectin? | Hepatology | 2004 | 928 |
| 36 | Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling | Genome Biology | 2016 | 912 |
| 37 | Clinical Pharmacokinetics of Metformin | Clinical Pharmacokinetics | 2011 | 910 |
| 38 | Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid | Diabetes | 1991 | 894 |
| 39 | Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee | Journal of Clinical Immunology | 2020 | 881 |
| 40 | BAFFANDAPRIL: A Tutorial on B Cell Survival | Annual Review of Immunology | 2003 | 874 |
| 41 | miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA | EMBO Journal | 2011 | 841 |
| 42 | Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer | Nature Reviews Cancer | 2015 | 839 |
| 43 | Criteria for Cure of Acromegaly: A Consensus Statement1† | Journal of Clinical Endocrinology and Metabolism | 2000 | 779 |
| 44 | Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events | Cell Cycle | 2014 | 773 |
| 45 | The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids | New England Journal of Medicine | 1993 | 772 |
| 46 | The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice | Cell Metabolism | 2014 | 768 |
| 47 | Chemokines: immunology's high impact factors | Nature Immunology | 2001 | 760 |
| 48 | Smoking and fracture risk: a meta-analysis | Osteoporosis International | 2005 | 755 |
| 49 | Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4 | Science | 2014 | 745 |
| 50 | Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes | Diabetologia | 2007 | 735 |
