| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 2 | ESPEN guidelines on definitions and terminology of clinical nutrition | Clinical Nutrition | 2017 | 1,451 |
| 3 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 1,294 |
| 4 | Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle | Nature Cell Biology | 2010 | 1,013 |
| 5 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 947 |
| 6 | Multislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes | Journal of the American College of Cardiology | 2007 | 936 |
| 7 | Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome | Nature | 2007 | 930 |
| 8 | Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients | Neuroscience Letters | 1994 | 884 |
| 9 | Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene | Nature Genetics | 1994 | 800 |
| 10 | De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia | Molecular Psychiatry | 2012 | 775 |
| 11 | Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients | Neuroscience Letters | 1994 | 770 |
| 12 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 723 |
| 13 | Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy | Nature Medicine | 2002 | 713 |
| 14 | Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments | Archives of Virology | 2008 | 642 |
| 15 | Plaque Characterization by Coronary Computed Tomography Angiography and the Likelihood of Acute Coronary Events in Mid-Term Follow-Up | Journal of the American College of Cardiology | 2015 | 639 |
| 16 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 17 | Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains | Acta Neuropathologica | 2003 | 619 |
| 18 | Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity | Immunity | 2006 | 601 |
| 19 | Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone | American Journal of Cardiology | 2001 | 583 |
| 20 | Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy | Science | 2014 | 579 |
| 21 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal | Journal of Gastroenterology | 2006 | 549 |
| 22 | Proline-directed and Non-proline-directed Phosphorylation of PHF-tau | Journal of Biological Chemistry | 1995 | 528 |
| 23 | Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle | Journal of Cell Science | 2011 | 517 |
| 24 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis | Annals of the Rheumatic Diseases | 2000 | 509 |
| 25 | Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 470 |
| 26 | CTLA-4 Gene Polymorphism at Position 49 in Exon 1 Reduces the Inhibitory Function of CTLA-4 and Contributes to the Pathogenesis of Graves’ Disease | Journal of Immunology | 2000 | 468 |
| 27 | Dicer is essential for formation of the heterochromatin structure in vertebrate cells | Nature Cell Biology | 2004 | 451 |
| 28 | ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms | Nature Genetics | 2008 | 423 |
| 29 | Narrow‐band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team | Digestive Endoscopy | 2016 | 410 |
| 30 | Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan | Stroke | 2008 | 404 |
| 31 | Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma | Cancer Research | 2014 | 389 |
| 32 | Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription | Nature Genetics | 2000 | 388 |
| 33 | Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos) | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 387 |
| 34 | Inflammatory Process in Parkinsons Disease: Role for Cytokines | Current Pharmaceutical Design | 2005 | 370 |
| 35 | Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors | Cell | 2009 | 354 |
| 36 | Snake venom proteases affecting hemostasis and thrombosis | BBA - Proteins and Proteomics | 2000 | 349 |
| 37 | Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures | European Heart Journal | 2012 | 349 |
| 38 | Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease | Neuroscience Letters | 1999 | 342 |
| 39 | Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age | Molecular Brain | 2016 | 342 |
| 40 | Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 335 |
| 41 | Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia | Human Molecular Genetics | 2004 | 334 |
| 42 | Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population | Science Translational Medicine | 2009 | 334 |
| 43 | Percutaneous Transluminal Pulmonary Angioplasty for the Treatment of Chronic Thromboembolic Pulmonary Hypertension | Circulation: Cardiovascular Interventions | 2012 | 323 |
| 44 | Chromosomally integrated human herpesvirus 6: questions and answers | Reviews in Medical Virology | 2012 | 320 |
| 45 | Disruption of Sexual Behavior in Male Aromatase-Deficient Mice Lacking Exons 1 and 2 of thecyp19Gene | Biochemical and Biophysical Research Communications | 1998 | 318 |
| 46 | Protein structure determination in living cells by in-cell NMR spectroscopy | Nature | 2009 | 317 |
| 47 | Diagnostic Criteria, Clinical Features, and Incidence of Thyroid Storm Based on Nationwide Surveys | Thyroid | 2012 | 315 |
| 48 | Clinical diagnostic criteria of IgG4‐related sclerosing cholangitis 2012 | Journal of Hepato-Biliary-Pancreatic Sciences | 2012 | 309 |
| 49 | Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo | Journal of Cell Biology | 2007 | 308 |
| 50 | Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning | Nature | 2006 | 302 |
