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Top Articles

#TitleJournalYearCitations
1PHENIX: a comprehensive Python-based system for macromolecular structure solutionActa Crystallographica Section D: Biological Crystallography201020,564
2Superoxide DismutaseJournal of Biological Chemistry196910,959
3Superoxide dismutase: Improved assays and an assay applicable to acrylamide gelsAnalytical Biochemistry197110,405
4Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesScience19938,329
5Rivaroxaban versus Warfarin in Nonvalvular Atrial FibrillationNew England Journal of Medicine20118,006
6MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORSNew England Journal of Medicine19967,967
7Apixaban versus Warfarin in Patients with Atrial FibrillationNew England Journal of Medicine20117,537
8Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelinesJournal of Extracellular Vesicles20186,961
9Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC)Depression and Anxiety20036,434
10Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature19936,331
11Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature20065,600
12IDH1andIDH2Mutations in GliomasNew England Journal of Medicine20095,285
13Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committeeJournal of Bone and Mineral Research19874,558
14PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience19974,506
15Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature19914,326
16Neuroinflammation in Alzheimer's diseaseLancet Neurology, The20154,129
17The Somatic Genomic Landscape of GlioblastomaCell20133,979
18Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America19933,938
19Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseNature19953,894
20Lipopolysaccharide EndotoxinsAnnual Review of Biochemistry20023,873
21The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunctionAmerican Journal of Obstetrics and Gynecology19963,822
22Clinical Rating Systems for the Ankle-Hindfoot, Midfoot, Hallux, and Lesser ToesFoot and Ankle International19943,774
23Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's diseaseNeurology19933,665
24The APACHE III Prognostic SystemChest19913,488
25Wnt signalling in stem cells and cancerNature20053,334
26Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and ManagementClinical Microbiology Reviews20153,304
27The biology of oxygen radicalsScience19783,189
28Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,122
29A Rating Instrument For Anxiety DisordersPsychosomatics19713,119
30Dopamine Receptors: From Structure to FunctionPhysiological Reviews19983,059
31The Warburg Effect: How Does it Benefit Cancer Cells?Trends in Biochemical Sciences20163,019
32Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in MiceScience20133,006
33Superoxide Radical and Superoxide DismutasesAnnual Review of Biochemistry19952,963
34Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic reviewMedical Teacher20052,861
35Synaptic Activity and the Construction of Cortical CircuitsScience19962,745
36Toward discovery science of human brain functionProceedings of the National Academy of Sciences of the United States of America20102,703
37Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of AmericaClinical Infectious Diseases20092,644
38A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin ResistanceCell Metabolism20092,597
39Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved TrialLancet, The20032,584
40Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT RecommendationsJournal of Pain20082,564
41Endoscopic sphincterotomy complications and their management: an attempt at consensusGastrointestinal Endoscopy19912,535
42Genome-wide association studies for complex traits: consensus, uncertainty and challengesNature Reviews Genetics20082,496
43Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of AmericaClinical Infectious Diseases20082,432
44Grading the severity of chronic painPain19922,409
45Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsGenes and Development20032,377
46Seven-transmembrane receptorsNature Reviews Molecular Cell Biology20022,357
47New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findingsAmerican Journal of Medicine19942,329
48Recommendations for Noninvasive Evaluation of Native Valvular RegurgitationJournal of the American Society of Echocardiography20172,269
49Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporterNature19962,267
50Lower Extremity Function and Subsequent Disability: Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance BatteryJournals of Gerontology - Series A Biological Sciences and Medical Sciences20002,264