# | Title | Journal | Year | Citations |
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1 | PHENIX: a comprehensive Python-based system for macromolecular structure solution | Acta Crystallographica Section D: Biological Crystallography | 2010 | 20,564 |
2 | Superoxide Dismutase | Journal of Biological Chemistry | 1969 | 10,959 |
3 | Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels | Analytical Biochemistry | 1971 | 10,405 |
4 | Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Science | 1993 | 8,329 |
5 | Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation | New England Journal of Medicine | 2011 | 8,006 |
6 | MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS | New England Journal of Medicine | 1996 | 7,967 |
7 | Apixaban versus Warfarin in Patients with Atrial Fibrillation | New England Journal of Medicine | 2011 | 7,537 |
8 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
9 | Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC) | Depression and Anxiety | 2003 | 6,434 |
10 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 6,331 |
11 | Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Nature | 2006 | 5,600 |
12 | IDH1andIDH2Mutations in Gliomas | New England Journal of Medicine | 2009 | 5,285 |
13 | Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee | Journal of Bone and Mineral Research | 1987 | 4,558 |
14 | PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer | Science | 1997 | 4,506 |
15 | Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease | Nature | 1991 | 4,326 |
16 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
17 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,979 |
18 | Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 3,938 |
19 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Nature | 1995 | 3,894 |
20 | Lipopolysaccharide Endotoxins | Annual Review of Biochemistry | 2002 | 3,873 |
21 | The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction | American Journal of Obstetrics and Gynecology | 1996 | 3,822 |
22 | Clinical Rating Systems for the Ankle-Hindfoot, Midfoot, Hallux, and Lesser Toes | Foot and Ankle International | 1994 | 3,774 |
23 | Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease | Neurology | 1993 | 3,665 |
24 | The APACHE III Prognostic System | Chest | 1991 | 3,488 |
25 | Wnt signalling in stem cells and cancer | Nature | 2005 | 3,334 |
26 | Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management | Clinical Microbiology Reviews | 2015 | 3,304 |
27 | The biology of oxygen radicals | Science | 1978 | 3,189 |
28 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
29 | A Rating Instrument For Anxiety Disorders | Psychosomatics | 1971 | 3,119 |
30 | Dopamine Receptors: From Structure to Function | Physiological Reviews | 1998 | 3,059 |
31 | The Warburg Effect: How Does it Benefit Cancer Cells? | Trends in Biochemical Sciences | 2016 | 3,019 |
32 | Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice | Science | 2013 | 3,006 |
33 | Superoxide Radical and Superoxide Dismutases | Annual Review of Biochemistry | 1995 | 2,963 |
34 | Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic review | Medical Teacher | 2005 | 2,861 |
35 | Synaptic Activity and the Construction of Cortical Circuits | Science | 1996 | 2,745 |
36 | Toward discovery science of human brain function | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 2,703 |
37 | Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,644 |
38 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance | Cell Metabolism | 2009 | 2,597 |
39 | Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial | Lancet, The | 2003 | 2,584 |
40 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,564 |
41 | Endoscopic sphincterotomy complications and their management: an attempt at consensus | Gastrointestinal Endoscopy | 1991 | 2,535 |
42 | Genome-wide association studies for complex traits: consensus, uncertainty and challenges | Nature Reviews Genetics | 2008 | 2,496 |
43 | Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America | Clinical Infectious Diseases | 2008 | 2,432 |
44 | Grading the severity of chronic pain | Pain | 1992 | 2,409 |
45 | Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs | Genes and Development | 2003 | 2,377 |
46 | Seven-transmembrane receptors | Nature Reviews Molecular Cell Biology | 2002 | 2,357 |
47 | New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings | American Journal of Medicine | 1994 | 2,329 |
48 | Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation | Journal of the American Society of Echocardiography | 2017 | 2,269 |
49 | Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter | Nature | 1996 | 2,267 |
50 | Lower Extremity Function and Subsequent Disability: Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance Battery | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 2,264 |