| # | Title | Journal | Year | Citations |
|---|
| 1 | Survival Outcomes for Patients with Metastatic Triple-Negative Breast Cancer: Implications for Clinical Practice and Trial Design | Clinical Breast Cancer | 2009 | 367 |
| 2 | Randomized Comparison of Gemcitabine, Dexamethasone, and Cisplatin Versus Dexamethasone, Cytarabine, and Cisplatin Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: NCIC-CTG LY.12 | Journal of Clinical Oncology | 2014 | 358 |
| 3 | Psychometric properties and responsiveness of the EORTC Quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer | Quality of Life Research | 1994 | 357 |
| 4 | Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: A placebo-controlled trial | Arthritis and Rheumatism | 2003 | 344 |
| 5 | Characterization of human embryonic stem cells with features of neoplastic progression | Nature Biotechnology | 2009 | 256 |
| 6 | Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial | Lancet, The | 2013 | 236 |
| 7 | Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy | Nature Genetics | 2009 | 205 |
| 8 | Canadian Consensus Conference on the Management of Gastroesophageal Reflux Disease in Adults – Update 2004 | Canadian Journal of Gastroenterology & Hepatology | 2005 | 204 |
| 9 | A Review of the Reliability and Validity of the Edmonton Symptom Assessment System | Current Oncology | 2009 | 198 |
| 10 | RARE TRISOMY MOSAICISM DIAGNOSED IN AMNIOCYTES, INVOLVING AN AUTOSOME OTHER THAN CHROMOSOMES 13, 18, 20, AND 21: KARYOTYPE/PHENOTYPE CORRELATIONS | | 1997 | 185 |
| 11 | Active surveillance for the management of localized prostate cancer: Guideline recommendations | Canadian Urological Association Journal | 2015 | 184 |
| 12 | Peritonitis in Continuous Ambulatory Peritoneal Dialysis {CAPD): A Multi-Centre Randomized Clinical Trial Comparing the Y Connector Disinfectant System to Standard Systems | Peritoneal Dialysis International | 1989 | 181 |
| 13 | Effect of postchemotherapy nausea and vomiting on health-related quality of life | Supportive Care in Cancer | 1997 | 176 |
| 14 | Collecting duct carcinoma of kidney | Seminars in Diagnostic Pathology | 1998 | 159 |
| 15 | Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000 | Clinical Genetics | 2003 | 134 |
| 16 | Models of care for post-treatment follow-up of adult cancer survivors: a systematic review and quality appraisal of the evidence | Journal of Cancer Survivorship | 2012 | 134 |
| 17 | Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers | Canadian Journal of Cardiology | 2007 | 131 |
| 18 | Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays | Human Molecular Genetics | 2013 | 120 |
| 19 | Use of Opioid Analgesics for the Treatment of Chronic Noncancer Pain - A Consensus Statement and Guidelines from the Canadian Pain Society, 2002 | Pain Research and Management | 2003 | 116 |
| 20 | The management of dyspnea in cancer patients: a systematic review | Supportive Care in Cancer | 2008 | 110 |
| 21 | Effect of schedule and maintenance on the antiemetic efficacy of ondansetron combined with dexamethasone in acute and delayed nausea and emesis in patients receiving moderately emetogenic chemotherapy: a phase III trial by the National Cancer Institute of Canada Clinical Trials Group. | Journal of Clinical Oncology | 1994 | 109 |
| 22 | High-resolution array CGH defines critical regions and candidate genes for microcephaly, abnormalities of the corpus callosum, and seizure phenotypes in patients with microdeletions of 1q43q44 | Human Genetics | 2012 | 105 |
| 23 | Current prognostic factors-renal cell carcinoma | Cancer | 1997 | 99 |
| 24 | Inflammatory Myofibroblastic Tumors of the Kidney: A Clinicopathologic and Immunohistochemical Study of 12 Cases | American Journal of Surgical Pathology | 2003 | 96 |
| 25 | Adding external beam to intra-luminal brachytherapy improves palliation in obstructive squamous cell oesophageal cancer: A prospective multi-centre randomized trial of the International Atomic Energy Agency | Radiotherapy and Oncology | 2010 | 86 |
| 26 | Breaking the Access Barrier | Chest | 2005 | 85 |
| 27 | Haploinsufficiency ofSOX5at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features | Human Mutation | 2012 | 85 |
| 28 | The use of Dual Lumen Jugular Venous Catheters as Definitive Long Term Access for Haemodialysis | International Journal of Artificial Organs | 1990 | 70 |
| 29 | 12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech | European Journal of Human Genetics | 2013 | 70 |
| 30 | Comparing peak and submaximal cardiorespiratory responses during field walking tests with incremental cycle ergometry in COPD | Respirology | 2012 | 68 |
| 31 | Canadian Cytogenetic Emergency Network (CEN) for biological dosimetry following radiological/nuclear accidents | International Journal of Radiation Biology | 2007 | 66 |
| 32 | Survivorship Services for Adult Cancer Populations: A Pan-Canadian Guideline | Current Oncology | 2011 | 64 |
| 33 | Prognostic factors in patients with metastatic colorectal cancer receiving 5-fluorouracil and folinic acid | European Journal of Cancer | 1992 | 61 |
| 34 | Emotion‐focused therapy in a case of anorexia nervosa | Clinical Psychology and Psychotherapy | 2009 | 60 |
| 35 | Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients | Journal of Bone and Mineral Metabolism | 2005 | 57 |
| 36 | Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer | Science Advances | 2020 | 56 |
| 37 | Adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer | Gynecologic Oncology | 2009 | 55 |
| 38 | Incidence and Management of Infusion Reactions to Infliximab in a Prospective Real-world Community Registry | Journal of Rheumatology | 2015 | 50 |
| 39 | Updated Protocol for the Examination of Specimens From Patients With Carcinomas of the Prostate Gland | Archives of Pathology and Laboratory Medicine | 2006 | 49 |
| 40 | Feasibility and safety of same-day discharge after minimally invasive hysterectomy in gynecologic oncology: A systematic review of the literature | Gynecologic Oncology | 2016 | 48 |
| 41 | Leiomyosarcoma of Urinary Bladder Following Cyclophosphamide Therapy: Report of Two Cases | Modern Pathology | 2003 | 45 |
| 42 | Telomere Attrition in Isolated High-Grade Prostatic Intraepithelial Neoplasia and Surrounding Stroma Is Predictive of Prostate Cancer | Neoplasia | 2007 | 44 |
| 43 | Intrarenal Schwannoma: A Report of Four Cases Including Three Cellular Variants | Modern Pathology | 2000 | 43 |
| 44 | Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disorders | Molecular Cytogenetics | 2012 | 43 |
| 45 | Evolution of foot orthotics—part 1: Coherent theory or coherent practice? | Journal of Manipulative and Physiological Therapeutics | 2002 | 42 |
| 46 | TMEM43 mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-Newfoundland populations | Human Genetics | 2013 | 42 |
| 47 | Non‐syndromic language delay in a child with disruption in the Protocadherin11X/Y gene pair | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 2011 | 40 |
| 48 | Recurrent HERV-H-Mediated 3q13.2-q13.31 Deletions Cause a Syndrome of Hypotonia and Motor, Language, and Cognitive Delays | Human Mutation | 2013 | 40 |
| 49 | The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry‐Based Randomized Trial: The EFFORT Trial | Journal of Parenteral and Enteral Nutrition | 2019 | 40 |
| 50 | Presentation, delay, and contraindication to thrombolytic treatment in females and males with myocardial infarction | Women's Health Issues | 2003 | 39 |
