| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 4,468 |
| 4 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 5 | HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis | Pediatric Blood and Cancer | 2007 | 4,018 |
| 6 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease | Cell Host and Microbe | 2014 | 2,582 |
| 7 | A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy | Cell | 1998 | 2,388 |
| 8 | Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States | Arthritis and Rheumatism | 1998 | 2,294 |
| 9 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 10 | A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells | Nucleic Acids Research | 1991 | 2,268 |
| 11 | Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents | Pediatrics | 2017 | 2,199 |
| 12 | The Human Transcription Factors | Cell | 2018 | 2,048 |
| 13 | Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012 | JAMA - Journal of the American Medical Association | 2015 | 2,008 |
| 14 | Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death | Nature | 2005 | 2,005 |
| 15 | Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism | Cell | 2002 | 1,823 |
| 16 | Human Milk Composition | Pediatric Clinics of North America | 2013 | 1,814 |
| 17 | Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis | Environmental Health Perspectives | 2005 | 1,750 |
| 18 | Regulation of cardiac hypertrophy by intracellular signalling pathways | Nature Reviews Molecular Cell Biology | 2006 | 1,680 |
| 19 | Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation | Nature Cell Biology | 2018 | 1,650 |
| 20 | Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases | Nature | 2019 | 1,638 |
| 21 | Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura | Nature | 2001 | 1,623 |
| 22 | Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management | Lancet Neurology, The | 2010 | 1,605 |
| 23 | MicroRNA | Journal of Allergy and Clinical Immunology | 2018 | 1,587 |
| 24 | Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage | Proceedings of the National Academy of Sciences of the United States of America | 1980 | 1,554 |
| 25 | Preterm labor: One syndrome, many causes | Science | 2014 | 1,478 |
| 26 | Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis | Clinical Chemistry and Laboratory Medicine | 2020 | 1,400 |
| 27 | Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis | Clinica Chimica Acta | 2020 | 1,289 |
| 28 | Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults | Nature | 2020 | 1,197 |
| 29 | Management of Sickle Cell Disease | JAMA - Journal of the American Medical Association | 2014 | 1,189 |
| 30 | Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009 | JAMA - Journal of the American Medical Association | 2014 | 1,160 |
| 31 | Ten-Year Research Update Review: Child Sexual Abuse | Journal of the American Academy of Child and Adolescent Psychiatry | 2003 | 1,155 |
| 32 | Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis | New England Journal of Medicine | 2008 | 1,138 |
| 33 | Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 1,125 |
| 34 | Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition | Science | 1974 | 1,119 |
| 35 | Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS | Nature Medicine | 1997 | 1,096 |
| 36 | Complex Trauma in Children and Adolescents | Psychiatric Annals | 2005 | 1,016 |
| 37 | Epidemiology ofEscherichia coliO157:H7 Outbreaks, United States, 1982–2002 | Emerging Infectious Diseases | 2005 | 1,015 |
| 38 | Biomechanical Measures during Landing and Postural Stability Predict Second Anterior Cruciate Ligament Injury after Anterior Cruciate Ligament Reconstruction and Return to Sport | American Journal of Sports Medicine | 2010 | 1,003 |
| 39 | The Clinical Importance of the Metabolite Equol—A Clue to the Effectiveness of Soy and Its Isoflavones | Journal of Nutrition | 2002 | 980 |
| 40 | Human susceptibility and resistance to Norwalk virus infection | Nature Medicine | 2003 | 956 |
| 41 | Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones | American Journal of Clinical Nutrition | 1998 | 947 |
| 42 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 43 | Dietary Isoflavones: Biological Effects and Relevance to Human Health | Journal of Nutrition | 1999 | 927 |
| 44 | Mechanisms of Anterior Cruciate Ligament Injury in Basketball | American Journal of Sports Medicine | 2007 | 923 |
| 45 | Preliminary definition of improvement in juvenile arthritis | Arthritis and Rheumatism | 1997 | 922 |
| 46 | Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies | Epilepsia | 2008 | 914 |
| 47 | Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis | New England Journal of Medicine | 2010 | 906 |
| 48 | Quantitative assessment of atherosclerotic lesions in mice | Atherosclerosis | 1987 | 894 |
| 49 | Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome | Science | 2005 | 878 |
| 50 | How I treat hemophagocytic lymphohistiocytosis | Blood | 2011 | 872 |
