| # | Title | Journal | Year | Citations |
|---|
| 1 | 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes | New England Journal of Medicine | 2008 | 6,543 |
| 2 | A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity | Science | 2007 | 3,884 |
| 3 | Congenital leptin deficiency is associated with severe early-onset obesity in humans | Nature | 1997 | 2,664 |
| 4 | Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes | Science | 2007 | 2,040 |
| 5 | Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) | Diabetologia | 2012 | 1,718 |
| 6 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 7 | Systematic identification of trans eQTLs as putative drivers of known disease associations | Nature Genetics | 2013 | 1,544 |
| 8 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,475 |
| 9 | Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study | Lancet, The | 2016 | 1,397 |
| 10 | Acromegaly: An Endocrine Society Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2014 | 1,312 |
| 11 | The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase | Science | 2007 | 1,305 |
| 12 | The Inverse Association Between Tuberculin Responses and Atopic Disorder | Science | 1997 | 1,220 |
| 13 | Common variants near MC4R are associated with fat mass, weight and risk of obesity | Nature Genetics | 2008 | 1,179 |
| 14 | High-intensity focused ultrasound in the treatment of solid tumours | Nature Reviews Cancer | 2005 | 1,100 |
| 15 | Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS | Nature Medicine | 1997 | 1,096 |
| 16 | Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake | Progress in Lipid Research | 2008 | 1,038 |
| 17 | Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP) | Tissue Antigens | 1995 | 1,005 |
| 18 | An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier | Nature | 1964 | 985 |
| 19 | EFFECT OF HUMAN ERYTHROPOIETIN DERIVED FROM RECOMBINANT DNA ON THE ANAEMIA OF PATIENTS MAINTAINED BY CHRONIC HAEMODIALYSIS | Lancet, The | 1986 | 978 |
| 20 | A BLINDED, RANDOMIZED CLINICAL TRIAL OF MYCOPHENOLATE MOFETIL FOR THE PREVENTION OF ACUTE REJECTION IN CADAVERIC RENAL TRANSPLANTATION1 | Transplantation | 1996 | 933 |
| 21 | Prevalence of pituitary adenomas: a community‐based, cross‐sectional study in Banbury (Oxfordshire, UK) | Clinical Endocrinology | 2010 | 930 |
| 22 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial | Lancet, The | 2011 | 849 |
| 23 | Snoring, sleep disturbance, and behaviour in 4-5 year olds. | Archives of Disease in Childhood | 1993 | 836 |
| 24 | Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial | Lancet Oncology, The | 2016 | 818 |
| 25 | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility | Nature Genetics | 2011 | 778 |
| 26 | Treatment of Adrenocorticotropin-Dependent Cushing’s Syndrome: A Consensus Statement | Journal of Clinical Endocrinology and Metabolism | 2008 | 774 |
| 27 | miR-375 maintains normal pancreatic α- and β-cell mass | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 710 |
| 28 | Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease | Nature Genetics | 1999 | 697 |
| 29 | Insulin granule dynamics in pancreatic beta cells | Diabetologia | 2003 | 696 |
| 30 | Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12 | Nature Genetics | 1996 | 682 |
| 31 | Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes | New England Journal of Medicine | 2008 | 674 |
| 32 | Antiangiogenic therapy in oncology: current status and future directions | Lancet, The | 2016 | 663 |
| 33 | Addition of Biphasic, Prandial, or Basal Insulin to Oral Therapy in Type 2 Diabetes | New England Journal of Medicine | 2007 | 651 |
| 34 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 631 |
| 35 | Anticonvulsant drugs for management of pain: a systematic review | BMJ: British Medical Journal | 1995 | 625 |
| 36 | Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection | New England Journal of Medicine | 2011 | 624 |
| 37 | Lifespan of human lymphocyte subsets defined by CD45 isoforms | Nature | 1992 | 617 |
| 38 | Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes | Diabetologia | 2015 | 598 |
| 39 | Impact of covert duplicate publication on meta-analysis: a case study | BMJ: British Medical Journal | 1997 | 595 |
| 40 | A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 | Nature Genetics | 2007 | 592 |
| 41 | Exercise management in type 1 diabetes: a consensus statement | Lancet Diabetes and Endocrinology,the | 2017 | 588 |
| 42 | The molecular classification of the clinical manifestations of Crohn's disease | Gastroenterology | 2002 | 584 |
| 43 | Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia | Blood | 2015 | 565 |
| 44 | Grand challenges in chronic non-communicable diseases | Nature | 2007 | 562 |
| 45 | Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome | Nature Genetics | 2006 | 557 |
| 46 | LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q | Lancet, The | 1989 | 555 |
| 47 | Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. | Thorax | 1991 | 548 |
| 48 | Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up | Clinical Endocrinology | 2005 | 540 |
| 49 | Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans | Nature Medicine | 2004 | 538 |
| 50 | Evolution and transmission of stable CTL escape mutations in HIV infection | Nature | 2001 | 523 |
