| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 2 | Antibody responses to SARS-CoV-2 in patients with COVID-19 | Nature Medicine | 2020 | 2,542 |
| 3 | Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections | Nature Medicine | 2020 | 2,499 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 5 | Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism | Molecular Psychiatry | 2016 | 1,397 |
| 6 | Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2016 | 1,121 |
| 7 | Diabetes as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies | Internal Medicine Journal | 2012 | 796 |
| 8 | Clinical features and treatment of COVID‐19 patients in northeast Chongqing | Journal of Medical Virology | 2020 | 785 |
| 9 | A protocol for rapid generation of recombinant adenoviruses using the AdEasy system | Nature Protocols | 2007 | 749 |
| 10 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 11 | Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery | ACS Nano | 2010 | 592 |
| 12 | Drug treatments for covid-19: living systematic review and network meta-analysis | BMJ, The | 2020 | 592 |
| 13 | Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 540 |
| 14 | Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 529 |
| 15 | The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population | British Journal of Cancer | 2005 | 520 |
| 16 | The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice | Science Advances | 2019 | 446 |
| 17 | Reduced default mode network functional connectivity in patients with recurrent major depressive disorder | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 441 |
| 18 | Voltammetric aptasensor for sulfadimethoxine using a nanohybrid composed of multifunctional fullerene, reduced graphene oxide and Pt@Au nanoparticles, and based on direct electron transfer to the active site of glucose oxidase | Mikrochimica Acta | 2019 | 403 |
| 19 | Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition | Molecular Psychiatry | 2016 | 400 |
| 20 | Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma | Scientific Reports | 2016 | 379 |
| 21 | Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway | Cancer Letters | 2017 | 378 |
| 22 | Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound | Ultrasound in Medicine and Biology | 2001 | 359 |
| 23 | Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China | Nature Medicine | 2020 | 352 |
| 24 | Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation | ACS Nano | 2017 | 350 |
| 25 | A Comprehensive Analysis of the Dual Roles of BMPs in Regulating Adipogenic and Osteogenic Differentiation of Mesenchymal Progenitor Cells | Stem Cells and Development | 2009 | 341 |
| 26 | Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients | Lupus | 2007 | 335 |
| 27 | World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics | World Allergy Organization Journal | 2015 | 332 |
| 28 | Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound | Journal of Hepatology | 2016 | 331 |
| 29 | Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models | Journal of Experimental Medicine | 2008 | 321 |
| 30 | 2D Ultrathin MXene‐Based Drug‐Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer | Advanced Healthcare Materials | 2018 | 316 |
| 31 | Regulation of osteogenic differentiation during skeletal development | Frontiers in Bioscience - Landmark | 2008 | 314 |
| 32 | Osteosarcoma Development and Stem Cell Differentiation | Clinical Orthopaedics and Related Research | 2008 | 307 |
| 33 | Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers | Molecular Therapy | 2017 | 305 |
| 34 | Controversies and evolving new mechanisms in subarachnoid hemorrhage | Progress in Neurobiology | 2014 | 304 |
| 35 | Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis | Aging | 2020 | 298 |
| 36 | Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview | Ultrasonics Sonochemistry | 2004 | 268 |
| 37 | The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer | Molecular Cancer | 2020 | 261 |
| 38 | A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer | British Journal of Cancer | 2003 | 260 |
| 39 | Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas | Cancer Cell International | 2020 | 260 |
| 40 | Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway | Cellular Signalling | 2011 | 257 |
| 41 | MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress | Circulation Research | 2013 | 256 |
| 42 | The Long-term Effect of Acupuncture for Migraine Prophylaxis | JAMA Internal Medicine | 2017 | 256 |
| 43 | Extracorporeal High Intensity Focused Ultrasound Ablation in the Treatment of Patients with Large Hepatocellular Carcinoma | Annals of Surgical Oncology | 2004 | 255 |
| 44 | Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties | Biomaterials | 2014 | 255 |
| 45 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients | Rheumatology International | 2009 | 253 |
| 46 | Feasibility of US-guided High-Intensity Focused Ultrasound Treatment in Patients with Advanced Pancreatic Cancer: Initial Experience | Radiology | 2005 | 252 |
| 47 | Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma | Oncotarget | 2016 | 251 |
| 48 | Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience | Ultrasound in Medicine and Biology | 2004 | 246 |
| 49 | World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines | Pediatric Allergy and Immunology | 2010 | 238 |
| 50 | Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis | International Journal of Environmental Research and Public Health | 2017 | 238 |
