| # | Title | Journal | Year | Citations |
|---|
| 1 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 2 | The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials | Lancet Oncology, The | 2013 | 1,141 |
| 3 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 4 | Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial | Lancet, The | 2004 | 542 |
| 5 | Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative | Endoscopy | 2017 | 533 |
| 6 | European consensus on the histopathology of inflammatory bowel disease | Journal of Crohn's and Colitis | 2013 | 521 |
| 7 | Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial | Lancet, The | 2007 | 520 |
| 8 | Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial | Lancet, The | 2015 | 494 |
| 9 | British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma | Gut | 2019 | 365 |
| 10 | Deep learning for prediction of colorectal cancer outcome: a discovery and validation study | Lancet, The | 2020 | 364 |
| 11 | Optimal Planning Target Volume for Stage I Testicular Seminoma: A Medical Research Council Randomized Trial | Journal of Clinical Oncology | 1999 | 363 |
| 12 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial | Lancet, The | 2011 | 362 |
| 13 | Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial | BMJ: British Medical Journal | 2007 | 344 |
| 14 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial | Lancet Oncology, The | 2013 | 333 |
| 15 | Risk Factors and Incidence of Macular Edema after Cataract Surgery | Ophthalmology | 2016 | 316 |
| 16 | Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: A randomised phase III trial | Radiotherapy and Oncology | 2011 | 309 |
| 17 | The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity | Radiotherapy and Oncology | 1994 | 257 |
| 18 | British Society of Gastroenterology position statement on serrated polyps in the colon and rectum | Gut | 2017 | 250 |
| 19 | The Cataract National Dataset electronic multicentre audit of 55 567 operations: risk stratification for posterior capsule rupture and vitreous loss | Eye | 2009 | 249 |
| 20 | Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program | Annals of Oncology | 2018 | 246 |
| 21 | The Cataract National Dataset electronic multi-centre audit of 55 567 operations: updating benchmark standards of care in the United Kingdom and internationally | Eye | 2009 | 234 |
| 22 | Diagnosis and treatment of pyoderma gangrenosum | BMJ: British Medical Journal | 2006 | 210 |
| 23 | Benchmark standards for refractive outcomes after NHS cataract surgery | Eye | 2009 | 203 |
| 24 | Bevacizumab for neovascular age related macular degeneration (ABC Trial): multicentre randomised double masked study | BMJ: British Medical Journal | 2010 | 186 |
| 25 | British Society of Gastroenterology/Association of Coloproctologists of Great Britain and Ireland guidelines for the management of large non-pedunculated colorectal polyps | Gut | 2015 | 175 |
| 26 | Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer | Journal of Clinical Oncology | 2020 | 175 |
| 27 | Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol | Lancet, The | 2022 | 173 |
| 28 | Interventions for Central Retinal Vein Occlusion | Ophthalmology | 2007 | 162 |
| 29 | Randomized clinical trial of mesh versus sutured wound closure after open abdominal aortic aneurysm surgery | British Journal of Surgery | 2010 | 153 |
| 30 | The management and outcome of anastomotic leaks in colorectal surgery | Colorectal Disease | 2008 | 151 |
| 31 | Impact of echocardiography on patient management in the intensive care unit: an audit of district general hospital practice | British Journal of Anaesthesia | 2009 | 151 |
| 32 | Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative | United European Gastroenterology Journal | 2017 | 149 |
| 33 | Reconstruction of the temporomandibular joint autogenous compared with alloplastic | British Journal of Oral and Maxillofacial Surgery | 2002 | 142 |
| 34 | Comparison of two reference standards in validating two field mydriatic digital photography as a method of screening for diabetic retinopathy | British Journal of Ophthalmology | 2003 | 138 |
| 35 | Risk Factors for Delayed Healing and Recurrence of Chronic Venous Leg Ulcers—An Analysis of 1324 Legs | European Journal of Vascular and Endovascular Surgery | 2005 | 137 |
| 36 | Review and update of central serous chorioretinopathy | Current Opinion in Ophthalmology | 2011 | 135 |
| 37 | 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial | Lancet Oncology, The | 2018 | 133 |
| 38 | Role of Lymphangiogenesis in Cancer | Journal of Clinical Oncology | 2007 | 132 |
| 39 | Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer—A clinical and pathological evaluation | Gynecologic Oncology | 2012 | 132 |
| 40 | Best time to assess complete clinical response after chemoradiotherapy in squamous cell carcinoma of the anus (ACT II): a post-hoc analysis of randomised controlled phase 3 trial | Lancet Oncology, The | 2017 | 132 |
| 41 | Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens | British Journal of Haematology | 2002 | 129 |
| 42 | Article Commentary: The English national screening programme for sight-threatening diabetic retinopathy | Journal of Medical Screening | 2008 | 126 |
| 43 | The effectiveness of screening for diabetic retinopathy by digital imaging photography and technician ophthalmoscopy | Diabetic Medicine | 2003 | 125 |
| 44 | Transient osteoporosis of the hip associated with osteogenesis imperfecta | Journal of Bone and Joint Surgery: British Volume | 1998 | 122 |
| 45 | The Influence of Age, Duration of Diabetes, Cataract, and Pupil Size on Image Quality in Digital Photographic Retinal Screening | Diabetes Care | 2005 | 121 |
| 46 | Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis | Alimentary Pharmacology and Therapeutics | 2003 | 120 |
| 47 | Cellular radiosensitivity and complication risk after curative radiotherapy | Radiotherapy and Oncology | 2000 | 115 |
| 48 | To Suspend or not to Suspend: A Randomised Single Blind Trial of Simple Trapeziectomy Versus Trapeziectomy and Flexor Carpi Radialis Suspension | Journal of Hand Surgery: European Volume | 2007 | 112 |
| 49 | Oral cancer diagnosis and delays in referral | British Journal of Oral and Maxillofacial Surgery | 1992 | 110 |
| 50 | Exploration of the common bile duct: A comparative study | British Journal of Surgery | 2005 | 106 |
