| # | Title | Journal | Year | Citations |
|---|
| 1 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,838 |
| 2 | Pathophysiology of Human Visceral Obesity: An Update | Physiological Reviews | 2013 | 1,751 |
| 3 | Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor | Science | 2002 | 1,671 |
| 4 | Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions | Biochemical Journal | 1999 | 1,541 |
| 5 | Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis | New England Journal of Medicine | 1997 | 886 |
| 6 | 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult | Canadian Journal of Cardiology | 2013 | 680 |
| 7 | Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 655 |
| 8 | 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations | Canadian Journal of Cardiology | 2009 | 653 |
| 9 | Workgroup Report: Drinking-Water Nitrate and Health—Recent Findings and Research Needs | Environmental Health Perspectives | 2005 | 621 |
| 10 | Poly(ADP-ribose) (PAR) polymer is a death signal | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 572 |
| 11 | The B1 receptors for kinins | Pharmacological Reviews | 1998 | 497 |
| 12 | PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites | Journal of Biological Chemistry | 2008 | 469 |
| 13 | Preparation of ready-to-use, storable and reconstituted type I collagen from rat tail tendon for tissue engineering applications | Nature Protocols | 2006 | 446 |
| 14 | Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel | Journal of Internal Medicine | 2006 | 405 |
| 15 | Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis | Journal of Biological Chemistry | 1999 | 400 |
| 16 | Hemocompatibility, biocompatibility, inflammatory andin vivostudies of primary reference materials low-density polyethylene and polydimethylsiloxane: A review | Journal of Biomedical Materials Research Part B | 2001 | 400 |
| 17 | Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial | Lancet, The | 2020 | 400 |
| 18 | Human Metapneumovirus Infections in Hospitalized Children1 | Emerging Infectious Diseases | 2003 | 395 |
| 19 | Species-Specific and Ubiquitous-DNA-Based Assays for Rapid Identification ofStaphylococcus aureus | Journal of Clinical Microbiology | 1998 | 392 |
| 20 | Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial | Journal of Clinical Lipidology | 2015 | 390 |
| 21 | Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy | Journal of Bone and Mineral Research | 2010 | 383 |
| 22 | New Real-Time PCR Assay for Rapid Detection of Methicillin- Resistant Staphylococcus aureus Directly from Specimens Containing a Mixture of Staphylococci | Journal of Clinical Microbiology | 2004 | 377 |
| 23 | Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial | Lancet Oncology, The | 2010 | 377 |
| 24 | Assessments of the extent to which health‐care providers involve patients in decision making: a systematic review of studies using the OPTION instrument | Health Expectations | 2015 | 374 |
| 25 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 367 |
| 26 | The effects of prior light history on the suppression of melatonin by light in humans | Journal of Pineal Research | 2002 | 362 |
| 27 | Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia | Blood | 2007 | 362 |
| 28 | Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1–Dependent Cell Death (Parthanatos) | Science Signaling | 2011 | 360 |
| 29 | Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes | Nucleic Acids Research | 2008 | 359 |
| 30 | High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies | American Journal of Human Genetics | 2017 | 337 |
| 31 | Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants | JAMA - Journal of the American Medical Association | 2015 | 316 |
| 32 | Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta | Current Biology | 1999 | 313 |
| 33 | Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition | Clinical Infectious Diseases | 2000 | 310 |
| 34 | A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population | Nature Genetics | 2010 | 309 |
| 35 | The stimulation of angiogenesis and collagen deposition by copper | Biomaterials | 2010 | 304 |
| 36 | Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial | Lancet Oncology, The | 2016 | 283 |
| 37 | Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases | Cell Death and Differentiation | 2001 | 282 |
| 38 | Vancomycin-Modified Nanoparticles for Efficient Targeting and Preconcentration of Gram-Positive and Gram-Negative Bacteria | ACS Nano | 2008 | 282 |
| 39 | PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining | Molecular Cell | 2011 | 278 |
| 40 | A Comparison of Hexaminolevulinate Fluorescence Cystoscopy and White Light Cystoscopy for the Detection of Carcinoma In Situ in Patients With Bladder Cancer: A Phase III, Multicenter Study | Journal of Urology | 2007 | 275 |
| 41 | A Phase III, Multicenter Comparison of Hexaminolevulinate Fluorescence Cystoscopy and White Light Cystoscopy for the Detection of Superficial Papillary Lesions in Patients With Bladder Cancer | Journal of Urology | 2007 | 269 |
| 42 | Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity | Journal of Virology | 1997 | 259 |
| 43 | Diagnosis of Nonalcoholic Fatty Liver Disease: Invasive versus Noninvasive | Seminars in Liver Disease | 2008 | 257 |
| 44 | Interprofessionalism and shared decision-making in primary care: a stepwise approach towards a new model | Journal of Interprofessional Care | 2011 | 242 |
| 45 | Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis | Journal of Cell Science | 2001 | 242 |
| 46 | Shared decision making: what do clinicians need to know and why should they bother? | Medical Journal of Australia | 2014 | 237 |
| 47 | Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. | Environmental Health Perspectives | 2000 | 232 |
| 48 | n−3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik | American Journal of Clinical Nutrition | 2001 | 231 |
| 49 | Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia | Journal of Immunology | 2002 | 225 |
| 50 | Ataxia Telangiectasia Mutated (ATM) Signaling Network Is Modulated by a Novel Poly(ADP-ribose)-dependent Pathway in the Early Response to DNA-damaging Agents | Journal of Biological Chemistry | 2007 | 225 |
