| # | Title | Journal | Year | Citations |
|---|
| 1 | The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure | New England Journal of Medicine | 2005 | 5,656 |
| 2 | EuroSCORE II | European Journal of Cardio-thoracic Surgery | 2012 | 2,159 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial | Lancet, The | 2009 | 1,292 |
| 4 | The perindopril in elderly people with chronic heart failure (PEP-CHF) study | European Heart Journal | 2006 | 1,280 |
| 5 | beta Blockade after myocardial infarction: systematic review and meta regression analysis | BMJ: British Medical Journal | 1999 | 1,211 |
| 6 | The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis | European Heart Journal | 2003 | 1,154 |
| 7 | Management of spontaneous pneumothorax: British Thoracic Society pleural disease guideline 2010 | Thorax | 2010 | 1,047 |
| 8 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial | Lancet, The | 2009 | 906 |
| 9 | Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial | Lancet, The | 2019 | 697 |
| 10 | State of the art: Using natriuretic peptide levels in clinical practice | European Journal of Heart Failure | 2008 | 691 |
| 11 | Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection | New England Journal of Medicine | 2011 | 624 |
| 12 | Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine | European Journal of Heart Failure | 2010 | 593 |
| 13 | Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase] | European Heart Journal | 2006 | 586 |
| 14 | EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study | PLoS ONE | 2013 | 576 |
| 15 | Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial | Lancet, The | 2016 | 556 |
| 16 | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network | British Journal of Cancer | 2011 | 545 |
| 17 | Artificial intelligence in medicine | Annals of the Royal College of Surgeons of England | 2004 | 533 |
| 18 | Worsening Renal Function and Prognosis in Heart Failure: Systematic Review and Meta-Analysis | Journal of Cardiac Failure | 2007 | 527 |
| 19 | Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey | Lancet, The | 2002 | 493 |
| 20 | Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis | Lancet, The | 2014 | 475 |
| 21 | The diagnosis and management of chronic cough | European Respiratory Journal | 2004 | 454 |
| 22 | Recommendations for the management of cough in adults | Thorax | 2006 | 450 |
| 23 | Stapling procedure for haemorrhoids versus Milligan-Morgan haemorrhoidectomy: randomised controlled trial | Lancet, The | 2000 | 428 |
| 24 | Myocardial perfusion scintigraphy: the evidence | European Journal of Nuclear Medicine and Molecular Imaging | 2004 | 424 |
| 25 | Detection of microplastics in human lung tissue using μFTIR spectroscopy | Science of the Total Environment | 2022 | 410 |
| 26 | Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study | Lancet Oncology, The | 2007 | 404 |
| 27 | Percutaneous Mitral Valve Edge-to-Edge Repair | Journal of the American College of Cardiology | 2014 | 398 |
| 28 | Structured telephone support or telemonitoring programmes for patients with chronic heart failure | Journal of the American College of Cardiology | 2010 | 389 |
| 29 | Abdominal wall metastases following laparoscopy | British Journal of Surgery | 2005 | 373 |
| 30 | The relationship between cholesterol and survival in patients with chronic heart failure | Journal of the American College of Cardiology | 2003 | 361 |
| 31 | The global epidemiology of chronic cough in adults: a systematic review and meta-analysis | European Respiratory Journal | 2015 | 332 |
| 32 | Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial | Pain | 2007 | 322 |
| 33 | Which components of heart failure programmes are effective? A systematic review and meta‐analysis of the outcomes of structured telephone support or telemonitoring as the primary component of chronic heart failure management in 8323 patients: Abridged Cochrane Review | European Journal of Heart Failure | 2011 | 319 |
| 34 | Lymphoma incidence, survival and prevalence 2004–2014: sub-type analyses from the UK’s Haematological Malignancy Research Network | British Journal of Cancer | 2015 | 315 |
| 35 | Myocardial viability as a determinant of the ejection fraction response to carvedilol in patients with heart failure (CHRISTMAS trial): randomised controlled trial | Lancet, The | 2003 | 302 |
| 36 | Opiate Therapy in Chronic Cough | American Journal of Respiratory and Critical Care Medicine | 2007 | 286 |
| 37 | Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE | European Journal of Heart Failure | 2006 | 282 |
| 38 | The CARE-HF study (CArdiac REsynchronisation in Heart Failure study): rationale, design and end-points | European Journal of Heart Failure | 2001 | 279 |
| 39 | Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer | European Journal of Cancer | 2012 | 273 |
| 40 | Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report | Blood | 2020 | 271 |
| 41 | Developing Therapies for Heart Failure With Preserved Ejection Fraction | JACC: Heart Failure | 2014 | 267 |
| 42 | The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure | European Heart Journal | 2005 | 266 |
| 43 | Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control | Annals of Oncology | 2014 | 247 |
| 44 | Six minute corridor walk test as an outcome measure for the assessment of treatment in randomized, blinded intervention trials of chronic heart failure: a systematic review | European Heart Journal | 2005 | 246 |
| 45 | Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma | Journal of Clinical Oncology | 2020 | 233 |
| 46 | Laparoscopic resection of colon Cancer: Consensus of the European Association of Endoscopic Surgery (EAES) | Surgical Endoscopy and Other Interventional Techniques | 2004 | 231 |
| 47 | Reliability of reporting left ventricular systolic function by echocardiography: A systematic review of 3 methods | American Heart Journal | 2003 | 230 |
| 48 | Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial | Lancet Oncology, The | 2015 | 221 |
| 49 | Evaluation of quality of life after laparoscopic surgery: evidence-based guidelines of the European Association for Endoscopic Surgery | Surgical Endoscopy and Other Interventional Techniques | 2004 | 220 |
| 50 | Non–Travel‐Associated Hepatitis E in England and Wales: Demographic, Clinical, and Molecular Epidemiological Characteristics | Journal of Infectious Diseases | 2005 | 220 |
