| # | Title | Journal | Year | Citations |
|---|
| 1 | Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2014 | 1,039 |
| 2 | Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus | Journal of Bone and Mineral Research | 2015 | 957 |
| 3 | Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities | Neuron | 2017 | 860 |
| 4 | CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity | Nature | 2017 | 624 |
| 5 | Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment | The Lancet Global Health | 2015 | 557 |
| 6 | Scaling up physical activity interventions worldwide: stepping up to larger and smarter approaches to get people moving | Lancet, The | 2016 | 508 |
| 7 | Helical reconstruction in RELION | Journal of Structural Biology | 2017 | 438 |
| 8 | A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer | Nature Genetics | 2017 | 427 |
| 9 | Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults | Preventive Medicine | 2015 | 419 |
| 10 | An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer | Cancer Cell | 2019 | 359 |
| 11 | Whole-genome sequencing of patients with rare diseases in a national health system | Nature | 2020 | 338 |
| 12 | Breast MRI: EUSOBI recommendations for women’s information | European Radiology | 2015 | 330 |
| 13 | Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials | PLoS Medicine | 2016 | 327 |
| 14 | Multiple sclerosis genetics | Lancet Neurology, The | 2014 | 319 |
| 15 | Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes | Diabetologia | 2017 | 313 |
| 16 | Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels | Nature Communications | 2018 | 295 |
| 17 | Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis | Intensive Care Medicine | 2018 | 250 |
| 18 | Comparative effectiveness of transitional care services in patients discharged from the hospital with heart failure: a systematic review and network meta‐analysis | European Journal of Heart Failure | 2017 | 236 |
| 19 | Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 219 |
| 20 | Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation | Chemical Science | 2014 | 201 |
| 21 | Physical activity trajectories and mortality: population based cohort study | BMJ: British Medical Journal | 2019 | 194 |
| 22 | Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis | Nature Communications | 2018 | 193 |
| 23 | Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth | Cell Reports | 2020 | 186 |
| 24 | Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans | Journal of Allergy and Clinical Immunology | 2018 | 185 |
| 25 | An early history of T cell-mediated cytotoxicity | Nature Reviews Immunology | 2018 | 179 |
| 26 | Germline selection shapes human mitochondrial DNA diversity | Science | 2019 | 178 |
| 27 | Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility | Nature Communications | 2015 | 173 |
| 28 | Directional dominance on stature and cognition in diverse human populations | Nature | 2015 | 173 |
| 29 | Artificial intelligence in breast imaging | Clinical Radiology | 2019 | 171 |
| 30 | Obesity and Multiple Sclerosis: A Mendelian Randomization Study | PLoS Medicine | 2016 | 171 |
| 31 | Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ | Redox Biology | 2015 | 159 |
| 32 | The different autophagy degradation pathways and neurodegeneration | Neuron | 2022 | 150 |
| 33 | An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death | Nature Genetics | 2017 | 149 |
| 34 | Whole-genome sequencing of a sporadic primary immunodeficiency cohort | Nature | 2020 | 148 |
| 35 | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass | Nature Communications | 2017 | 147 |
| 36 | Regulation of the cerebral circulation: bedside assessment and clinical implications | Critical Care | 2016 | 146 |
| 37 | Contribution of Major Lifestyle Risk Factors for Incident Heart Failure in Older Adults | JACC: Heart Failure | 2015 | 134 |
| 38 | Brain ultrasonography: methodology, basic and advanced principles and clinical applications. A narrative review | Intensive Care Medicine | 2019 | 132 |
| 39 | Autophagy impairment in Parkinson’s disease | Essays in Biochemistry | 2017 | 125 |
| 40 | Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial | PLoS Medicine | 2016 | 117 |
| 41 | Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion | Nature Communications | 2019 | 117 |
| 42 | Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 116 |
| 43 | Individualizing Thresholds of Cerebral Perfusion Pressure Using Estimated Limits of Autoregulation | Critical Care Medicine | 2017 | 116 |
| 44 | Stenting for symptomatic vertebral artery stenosis | Neurology | 2017 | 116 |
| 45 | Behavioural Risk Factors in Mid-Life Associated with Successful Ageing, Disability, Dementia and Frailty in Later Life: A Rapid Systematic Review | PLoS ONE | 2016 | 112 |
| 46 | Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2 | Nature Genetics | 2017 | 105 |
| 47 | Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report | Nature Communications | 2020 | 103 |
| 48 | Time matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis? | Journal of Neurology, Neurosurgery and Psychiatry | 2018 | 102 |
| 49 | Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA | Molecular Cell | 2018 | 102 |
| 50 | Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes | Nature Communications | 2018 | 99 |
