| # | Title | Journal | Year | Citations |
|---|
| 1 | Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer | New England Journal of Medicine | 2004 | 9,850 |
| 2 | 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative | Arthritis and Rheumatism | 2010 | 6,781 |
| 3 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 4 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 | Intensive Care Medicine | 2013 | 3,906 |
| 6 | Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial | Lancet, The | 2018 | 3,542 |
| 7 | Gait Speed and Survival in Older Adults | JAMA - Journal of the American Medical Association | 2011 | 3,254 |
| 8 | 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2010 | 2,994 |
| 9 | Mechanisms of mindfulness | Journal of Clinical Psychology | 2006 | 2,465 |
| 10 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Critical Care Medicine | 2017 | 2,336 |
| 11 | High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays | Nature Genetics | 1998 | 2,066 |
| 12 | Requirement for IL-13 Independently of IL-4 in Experimental Asthma | Science | 1998 | 1,801 |
| 13 | 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer | Clinical Infectious Diseases | 2002 | 1,738 |
| 14 | Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial | Lancet Oncology, The | 2017 | 1,388 |
| 15 | Intensive Lifestyle Changes for Reversal of Coronary Heart Disease | JAMA - Journal of the American Medical Association | 1998 | 1,345 |
| 16 | ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus | American Journal of Gastroenterology | 2016 | 1,275 |
| 17 | Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour | Critical Care Medicine | 2014 | 1,159 |
| 18 | Genomic and transcriptional aberrations linked to breast cancer pathophysiologies | Cancer Cell | 2006 | 1,125 |
| 19 | Rifaximin Treatment in Hepatic Encephalopathy | New England Journal of Medicine | 2010 | 1,116 |
| 20 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
| 21 | An Optical Coherence Tomography-Guided, Variable Dosing Regimen with Intravitreal Ranibizumab (Lucentis) for Neovascular Age-related Macular Degeneration | American Journal of Ophthalmology | 2007 | 935 |
| 22 | Mindfulness-Based Stress Reduction for Health Care Professionals: Results From a Randomized Trial. | International Journal of Stress Management | 2005 | 914 |
| 23 | BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long-Term Results From the Study of Osteoporotic Fractures | Journal of Bone and Mineral Research | 2003 | 862 |
| 24 | ACG Clinical Guideline: Management of Crohn's Disease in Adults | American Journal of Gastroenterology | 2018 | 851 |
| 25 | Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study | PLoS Medicine | 2018 | 771 |
| 26 | Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review) | Neurology | 2009 | 749 |
| 27 | Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial | Lancet Oncology, The | 2015 | 699 |
| 28 | A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease | Neurology | 2009 | 677 |
| 29 | 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study | Lancet Neurology, The | 2010 | 674 |
| 30 | Depressive Symptoms and Health-Related Quality of Life | JAMA - Journal of the American Medical Association | 2003 | 669 |
| 31 | Ablation Versus Amiodarone for Treatment of Persistent Atrial Fibrillation in Patients With Congestive Heart Failure and an Implanted Device | Circulation | 2016 | 630 |
| 32 | Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial | Lancet Neurology, The | 2007 | 610 |
| 33 | Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review) | Neurology | 2009 | 607 |
| 34 | Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine | American Journal of Gastroenterology | 2008 | 588 |
| 35 | The IASP classification of chronic pain for ICD-11: chronic neuropathic pain | Pain | 2019 | 571 |
| 36 | Frailty and Risk of Falls, Fracture, and Mortality in Older Women: The Study of Osteoporotic Fractures | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2007 | 569 |
| 37 | Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes | JAMA - Journal of the American Medical Association | 2011 | 561 |
| 38 | Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene | Nature Genetics | 2000 | 555 |
| 39 | The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT) | Journal of Bone and Mineral Research | 2012 | 552 |
| 40 | Senescent cells as a source of inflammatory factors for tumor progression | Cancer and Metastasis Reviews | 2010 | 550 |
| 41 | Fecal Microbiota Transplant for Treatment of Clostridium difficile Infection in Immunocompromised Patients | American Journal of Gastroenterology | 2014 | 546 |
| 42 | Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison | Lancet, The | 2005 | 541 |
| 43 | Distraction osteogenesis in maxillofacial surgery using internal devices: Review of five cases | Journal of Oral and Maxillofacial Surgery | 1996 | 534 |
| 44 | Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis | BMC Medicine | 2016 | 534 |
| 45 | Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas | Science | 1996 | 531 |
| 46 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B | Gastroenterology | 2009 | 527 |
| 47 | Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial | Epilepsia | 2014 | 520 |
| 48 | Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) | The Cochrane Library | 2012 | 518 |
| 49 | ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding | American Journal of Gastroenterology | 2015 | 504 |
| 50 | Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis | New England Journal of Medicine | 2014 | 501 |
