# | Title | Journal | Year | Citations |
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1 | Cancer Epigenetics: From Mechanism to Therapy | Cell | 2012 | 2,521 |
2 | Requirement of bic/microRNA-155 for Normal Immune Function | Science | 2007 | 1,786 |
3 | Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia | Nature | 2011 | 1,354 |
4 | Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice | Nature Neuroscience | 2014 | 1,067 |
5 | Building the mammalian heart from two sources of myocardial cells | Nature Reviews Genetics | 2005 | 1,051 |
6 | The genomic substrate for adaptive radiation in African cichlid fish | Nature | 2014 | 874 |
7 | Histone core modifications regulating nucleosome structure and dynamics | Nature Reviews Molecular Cell Biology | 2014 | 775 |
8 | Histone Deimination Antagonizes Arginine Methylation | Cell | 2004 | 744 |
9 | Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses | Nature Neuroscience | 2012 | 726 |
10 | microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells | Immunity | 2007 | 724 |
11 | Guided self-organization and cortical plate formation in human brain organoids | Nature Biotechnology | 2017 | 606 |
12 | JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin | Nature | 2009 | 564 |
13 | Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium | Nature Cell Biology | 2017 | 442 |
14 | BET inhibitor resistance emerges from leukaemia stem cells | Nature | 2015 | 441 |
15 | Reversing histone methylation | Nature | 2005 | 440 |
16 | Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair | Journal of Biological Chemistry | 2009 | 420 |
17 | Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 396 |
18 | The roles of DNA, RNA and histone methylation in ageing and cancer | Nature Reviews Molecular Cell Biology | 2019 | 359 |
19 | The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth | EMBO Journal | 2005 | 352 |
20 | The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis | PLoS Genetics | 2009 | 347 |
21 | Function, Targets, and Evolution of Caenorhabditis elegans piRNAs | Science | 2012 | 339 |
22 | Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation | Nature | 2007 | 322 |
23 | η-Secretase processing of APP inhibits neuronal activity in the hippocampus | Nature | 2015 | 308 |
24 | 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size | Cell Stem Cell | 2016 | 292 |
25 | Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression | Cell | 2006 | 277 |
26 | A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome | Science Translational Medicine | 2012 | 276 |
27 | The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | Nature Cell Biology | 2008 | 270 |
28 | DNA methylation dynamics during the mammalian life cycle | Philosophical Transactions of the Royal Society B: Biological Sciences | 2013 | 262 |
29 | Histone post-translational modifications — cause and consequence of genome function | Nature Reviews Genetics | 2022 | 253 |
30 | Mitosis: a matter of getting rid of the right protein at the right time | Trends in Cell Biology | 2006 | 229 |
31 | Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens | Nature Cell Biology | 2012 | 224 |
32 | A walk through tau therapeutic strategies | Acta Neuropathologica Communications | 2019 | 211 |
33 | Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy | Cancer Research | 2015 | 193 |
34 | Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition | Journal of Medicinal Chemistry | 2016 | 177 |
35 | Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia | Leukemia | 2014 | 152 |
36 | Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness | Developmental Cell | 2013 | 149 |
37 | Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways | Cell Reports | 2018 | 147 |
38 | Histone H3 tail clipping regulates gene expression | Nature Structural and Molecular Biology | 2009 | 136 |
39 | Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex | Cold Spring Harbor Perspectives in Biology | 2009 | 125 |
40 | Small RNAs break out: the molecular cell biology of mobile small RNAs | Nature Reviews Molecular Cell Biology | 2014 | 122 |
41 | Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes | Traffic | 2015 | 122 |
42 | LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease | Nature Cell Biology | 2011 | 121 |
43 | APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase | Current Biology | 2008 | 120 |
44 | Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo | Mechanisms of Development | 2005 | 115 |
45 | How to make a primordial germ cell | Development (Cambridge) | 2014 | 111 |
46 | Dppa2andDppa4Are Closely Linked SAP Motif Genes Restricted to Pluripotent Cells and the Germ Line | Stem Cells | 2007 | 109 |
47 | Revisiting the Flight of Icarus: Making Human Organs from PSCs with Large Animal Chimeras | Cell Stem Cell | 2014 | 108 |
48 | How APC/C–Cdc20 changes its substrate specificity in mitosis | Nature Cell Biology | 2011 | 100 |
49 | Ikaros promotes early-born neuronal fates in the cerebral cortex | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 99 |
50 | The Drosophila hnRNPA/B Homolog, Hrp48, Is Specifically Required for a Distinct Step in osk mRNA Localization | Developmental Cell | 2004 | 97 |