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Top Articles

#TitleJournalYearCitations
1Cancer Epigenetics: From Mechanism to TherapyCell20122,521
2Requirement of bic/microRNA-155 for Normal Immune FunctionScience20071,786
3Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature20111,354
4Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in miceNature Neuroscience20141,067
5Building the mammalian heart from two sources of myocardial cellsNature Reviews Genetics20051,051
6The genomic substrate for adaptive radiation in African cichlid fishNature2014874
7Histone core modifications regulating nucleosome structure and dynamicsNature Reviews Molecular Cell Biology2014775
8Histone Deimination Antagonizes Arginine MethylationCell2004744
9Human cerebral cortex development from pluripotent stem cells to functional excitatory synapsesNature Neuroscience2012726
10microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma CellsImmunity2007724
11Guided self-organization and cortical plate formation in human brain organoidsNature Biotechnology2017606
12JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatinNature2009564
13Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined mediumNature Cell Biology2017442
14BET inhibitor resistance emerges from leukaemia stem cellsNature2015441
15Reversing histone methylationNature2005440
16Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break RepairJournal of Biological Chemistry2009420
17Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortexProceedings of the National Academy of Sciences of the United States of America2010396
18The roles of DNA, RNA and histone methylation in ageing and cancerNature Reviews Molecular Cell Biology2019359
19The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growthEMBO Journal2005352
20The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and NeurogenesisPLoS Genetics2009347
21Function, Targets, and Evolution of Caenorhabditis elegans piRNAsScience2012339
22Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylationNature2007322
23η-Secretase processing of APP inhibits neuronal activity in the hippocampusNature2015308
242D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain SizeCell Stem Cell2016292
25Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene ExpressionCell2006277
26A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down SyndromeScience Translational Medicine2012276
27The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destructionNature Cell Biology2008270
28DNA methylation dynamics during the mammalian life cyclePhilosophical Transactions of the Royal Society B: Biological Sciences2013262
29Histone post-translational modifications — cause and consequence of genome functionNature Reviews Genetics2022253
30Mitosis: a matter of getting rid of the right protein at the right timeTrends in Cell Biology2006229
31Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherensNature Cell Biology2012224
32A walk through tau therapeutic strategiesActa Neuropathologica Communications2019211
33Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia TherapyCancer Research2015193
34Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 InhibitionJournal of Medicinal Chemistry2016177
35Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemiaLeukemia2014152
36Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and ThicknessDevelopmental Cell2013149
37Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct PathwaysCell Reports2018147
38Histone H3 tail clipping regulates gene expressionNature Structural and Molecular Biology2009136
39Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral CortexCold Spring Harbor Perspectives in Biology2009125
40Small RNAs break out: the molecular cell biology of mobile small RNAsNature Reviews Molecular Cell Biology2014122
41Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and AutophagosomesTraffic2015122
42LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell diseaseNature Cell Biology2011121
43APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at AnaphaseCurrent Biology2008120
44Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryoMechanisms of Development2005115
45How to make a primordial germ cellDevelopment (Cambridge)2014111
46Dppa2andDppa4Are Closely Linked SAP Motif Genes Restricted to Pluripotent Cells and the Germ LineStem Cells2007109
47Revisiting the Flight of Icarus: Making Human Organs from PSCs with Large Animal ChimerasCell Stem Cell2014108
48How APC/C–Cdc20 changes its substrate specificity in mitosisNature Cell Biology2011100
49Ikaros promotes early-born neuronal fates in the cerebral cortexProceedings of the National Academy of Sciences of the United States of America201399
50The Drosophila hnRNPA/B Homolog, Hrp48, Is Specifically Required for a Distinct Step in osk mRNA LocalizationDevelopmental Cell200497