| # | Title | Journal | Year | Citations |
|---|
| 1 | Hip fractures in the elderly: A world-wide projection | Osteoporosis International | 1992 | 2,560 |
| 2 | Stool Form Scale as a Useful Guide to Intestinal Transit Time | Scandinavian Journal of Gastroenterology | 1997 | 2,375 |
| 3 | The operation of the century: total hip replacement | Lancet, The | 2007 | 1,907 |
| 4 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial | Lancet, The | 2008 | 1,759 |
| 5 | ROBIS: A new tool to assess risk of bias in systematic reviews was developed | Journal of Clinical Epidemiology | 2016 | 1,204 |
| 6 | Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery | Circulation | 2007 | 1,174 |
| 7 | The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis.. | British Journal of Dermatology | 1994 | 990 |
| 8 | The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study | Intensive Care Medicine | 1999 | 983 |
| 9 | Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist | Arthritis and Rheumatism | 1998 | 920 |
| 10 | Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis | Journal of the American College of Cardiology | 2011 | 839 |
| 11 | 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease | European Heart Journal | 2021 | 830 |
| 12 | Adipose tissue as an endocrine and paracrine organ | International Journal of Obesity | 1998 | 782 |
| 13 | Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes | Diabetes | 2005 | 745 |
| 14 | Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture | Physiological Reviews | 2005 | 730 |
| 15 | Chronic Autoimmune Thyroiditis | New England Journal of Medicine | 1996 | 715 |
| 16 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography11This study was performed without additional financial support. | Journal of the American College of Cardiology | 2001 | 710 |
| 17 | Early enteral feeding versus "nil by mouth" after gastrointestinal surgery: systematic review and meta-analysis of controlled trials | BMJ: British Medical Journal | 2001 | 691 |
| 18 | ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases | Oxidative Medicine and Cellular Longevity | 2016 | 661 |
| 19 | Haematogenous metastastic patterns in colonic carcinoma: An analysis of 1541 necropsies | Journal of Pathology | 1986 | 629 |
| 20 | Developing Core Outcome Measurement Sets for Clinical Trials: OMERACT Filter 2.0 | Journal of Clinical Epidemiology | 2014 | 625 |
| 21 | A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 | Nature Medicine | 2003 | 616 |
| 22 | A prognostic index for ductal carcinoma in situ of the breast | Nature Medicine | 1996 | 606 |
| 23 | Risk factors for the incidence and progression of radiographic knee osteoarthritis | Arthritis and Rheumatism | 2000 | 582 |
| 24 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease | Clinical Gastroenterology and Hepatology | 2013 | 564 |
| 25 | Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update | Journal of Cardiovascular Magnetic Resonance | 2020 | 550 |
| 26 | Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia | Cancer Cell | 2011 | 545 |
| 27 | 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung | European Respiratory Journal | 2017 | 543 |
| 28 | Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials | Lancet, The | 2002 | 531 |
| 29 | Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial | Gut | 2006 | 524 |
| 30 | Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit | Anaesthesia | 1999 | 504 |
| 31 | Molecular mechanisms in intimal hyperplasia | Anaesthesia | 2000 | 504 |
| 32 | Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. | Annals of the Rheumatic Diseases | 1992 | 495 |
| 33 | Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB | FEBS Letters | 1998 | 465 |
| 34 | Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial | Lancet, The | 2015 | 455 |
| 35 | Impaired fatty acid oxidation in propofol infusion syndrome | Lancet, The | 2001 | 451 |
| 36 | Inflammatory response after coronary revascularization with or without cardiopulmonary bypass | Annals of Thoracic Surgery | 2000 | 448 |
| 37 | Determinants of disability in osteoarthritis of the knee. | Annals of the Rheumatic Diseases | 1993 | 445 |
| 38 | Rational design and application of responsive α-helical peptide hydrogels | Nature Materials | 2009 | 441 |
| 39 | Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. | BMJ: British Medical Journal | 1990 | 435 |
| 40 | Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates | Cardiovascular Research | 2006 | 435 |
| 41 | Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions | European Heart Journal | 2018 | 431 |
| 42 | Psychological well-being in patients on ‘adequate’ doses of l -thyroxine: results of a large, controlled community-based questionnaire study | Clinical Endocrinology | 2002 | 430 |
| 43 | Computed tomography in pulmonary emphysema | Clinical Radiology | 1982 | 425 |
| 44 | Randomized Comparison of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Diabetic Patients | Journal of the American College of Cardiology | 2010 | 421 |
| 45 | European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection | European Heart Journal | 2018 | 421 |
| 46 | Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart | Biochimica Et Biophysica Acta - Bioenergetics | 1998 | 418 |
| 47 | Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. | Journal of Clinical Investigation | 1998 | 416 |
| 48 | Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability | Arteriosclerosis, Thrombosis, and Vascular Biology | 2008 | 413 |
| 49 | Bone Deformation Recorded in vivo from Strain Gauges Attached to the Human Tibial Shaft | Acta Orthopaedica | 1975 | 408 |
| 50 | E-cadherin—catenin cell—cell adhesion complex and human cancer | British Journal of Surgery | 2002 | 389 |
