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Boston Biomedical Research Institute
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top-articles
Boston Biomedical Research Institute
1.1K
(top 1%)
papers
56.0K
(top 0.1%)
citations
115
(top 0.1%)
h
-index
191
(top 0.1%)
g
-index
1.1K
all documents
58.2K
doc citations
4.0K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Signalling through the lipid products of phosphoinositide-3-OH kinase
Nature
1997
1,290
2
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Nature
2013
1,249
3
Cellular Defenses against Unfolded Proteins
Neuron
2001
948
4
Mechanisms of smooth muscle contraction
Physiological Reviews
1996
659
5
Regulation of protein kinase C ζ by PI 3-kinase and PDK-1
Current Biology
1998
600
6
Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion
Cell
1997
588
7
Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element
Gene
1997
579
8
Boundary analysis in sedimentation transport experiments: A procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile
Analytical Biochemistry
1992
572
9
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
Brain Research
2012
572
10
The Rat Grimace Scale: A Partially Automated Method for Quantifying Pain in the Laboratory Rat via Facial Expressions
Molecular Pain
2011
521
11
Mechanical compression drives cancer cells toward invasive phenotype
Proceedings of the National Academy of Sciences of the United States of America
2012
507
12
The Crystal Structure of Uncomplexed Actin in the ADP State
Science
2001
484
13
Hsp70 Prevents Activation of Stress Kinases
Journal of Biological Chemistry
1997
473
14
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Cancer Cell
2009
472
15
Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site
Journal of Biological Chemistry
2000
436
16
Protein Splicing and Related Forms of Protein Autoprocessing
Annual Review of Biochemistry
2000
420
17
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
Proceedings of the National Academy of Sciences of the United States of America
2006
418
18
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
Cancer Cell
2009
411
19
Rotational diffusion studied by passage saturation transfer electron paramagnetic resonance
Journal of Chemical Physics
1976
410
20
Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT
Molecular Cell
2005
390
21
Identification of the
miR-106b
~
25
MicroRNA Cluster as a Proto-Oncogenic
PTEN
-Targeting Intron That Cooperates with Its Host Gene
MCM7
in Transformation
Science Signaling
2010
390
22
Thin Filament Proteins and Thin Filament-Linked Regulation of Vertebrate Muscle Contractio
Critical Reviews in Biochemistry
1984
388
23
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Nature
2002
388
24
A yeast functional screen predicts new candidate ALS disease genes
Proceedings of the National Academy of Sciences of the United States of America
2011
365
25
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
Current Biology
1998
357
26
Structural basis of protein phosphatase 1 regulation
Nature
2004
355
27
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
Cell
2012
339
28
Structural Basis for Diversity of the EF-hand Calcium-binding Proteins
Journal of Molecular Biology
2006
334
29
The motor protein myosin-I produces its working stroke in two steps
Nature
1999
328
30
Signaling through protein kinase C
Frontiers in Bioscience - Landmark
1998
294
31
Purification and Properties of the Components from Troponin
Journal of Biological Chemistry
1973
293
32
Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72
Journal of Biological Chemistry
1998
280
33
Fast and slow dynamics of the cytoskeleton
Nature Materials
2006
279
34
Three-dimensional structure of adenyl kinase
Nature
1974
277
35
Prion-like disorders: blurring the divide between transmissibility and infectivity
Journal of Cell Science
2010
268
36
The amino acid sequence of rabbit skeletal muscle troponin C: Gene replication and homology with calcium -binding proteins from carp and hake muscle
FEBS Letters
1973
261
37
The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
Current Opinion in Cell Biology
1998
257
38
Analysis of heterologous interacting systems by sedimentation velocity: curve fitting algorithms for estimation of sedimentation coefficients, equilibrium and kinetic constants
Biophysical Chemistry
2004
246
39
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
Human Molecular Genetics
2012
246
40
Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments
Science
1985
244
41
Postulated role of calsequestrin in the regulation of calcium release from sarcoplasmic reticulum
Biochemistry
1989
234
42
Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72
Molecular and Cellular Biology
1999
234
43
Protein Splicing Involving the Saccharomyces cerevisiae VMA Intein
Journal of Biological Chemistry
1996
233
44
The content of troponin, tropomyosin, actin, and myosin in rabbit skeletal muscle myofibrils
Archives of Biochemistry and Biophysics
1974
229
45
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proceedings of the National Academy of Sciences of the United States of America
2005
228
46
Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP
Current Biology
2003
222
47
Leptin Signaling Promotes the Growth of Mammary Tumors and Increases the Expression of Vascular Endothelial Growth Factor (VEGF) and Its Receptor Type Two (VEGF-R2)
Journal of Biological Chemistry
2006
216
48
Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging
FEBS Letters
1998
215
49
Phosphoinositides and signal transduction
Cellular and Molecular Life Sciences
2002
213
50
Invited Review: Cross-bridge regulation by thin filament-associated proteins
Journal of Applied Physiology
2001
212
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