| # | Title | Journal | Year | Citations |
|---|
| 1 | PhysioBank, PhysioToolkit, and PhysioNet | Circulation | 2000 | 10,241 |
| 2 | The basics of epithelial-mesenchymal transition | Journal of Clinical Investigation | 2009 | 8,252 |
| 3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 4 | Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells | Nature | 2006 | 6,365 |
| 5 | A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? | Cell | 2011 | 5,954 |
| 6 | Trends in Alternative Medicine Use in the United States, 1990-1997 | JAMA - Journal of the American Medical Association | 1998 | 5,828 |
| 7 | AKT/PKB Signaling: Navigating Downstream | Cell | 2007 | 5,261 |
| 8 | The Phosphoinositide 3-Kinase Pathway | Science | 2002 | 5,004 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 10 | Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients | Nature | 2014 | 4,342 |
| 11 | Adipose Tissue as an Endocrine Organ | Journal of Clinical Endocrinology and Metabolism | 2004 | 4,205 |
| 12 | MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling | Science | 2007 | 4,187 |
| 13 | MIMIC-III, a freely accessible critical care database | Scientific Data | 2016 | 4,097 |
| 14 | Unconventional Medicine in the United States -- Prevalence, Costs, and Patterns of Use | New England Journal of Medicine | 1993 | 3,908 |
| 15 | Rules for Scoring Respiratory Events in Sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events | Journal of Clinical Sleep Medicine | 2012 | 3,887 |
| 16 | Renal clearance of quantum dots | Nature Biotechnology | 2007 | 3,789 |
| 17 | EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib | New England Journal of Medicine | 2005 | 3,715 |
| 18 | Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase | Nature Medicine | 2002 | 3,692 |
| 19 | Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid | Science | 1983 | 3,557 |
| 20 | Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 | Cell | 1999 | 3,545 |
| 21 | Analysis of nanoparticle delivery to tumours | Nature Reviews Materials | 2016 | 3,393 |
| 22 | Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia | Journal of Clinical Investigation | 2003 | 3,356 |
| 23 | The landscape of somatic copy-number alteration across human cancers | Nature | 2010 | 3,331 |
| 24 | The multilayered complexity of ceRNA crosstalk and competition | Nature | 2014 | 3,223 |
| 25 | Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series | Chaos | 1995 | 3,180 |
| 26 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 27 | Tumorigenesis and the angiogenic switch | Nature Reviews Cancer | 2003 | 3,059 |
| 28 | TLR4 links innate immunity and fatty acid–induced insulin resistance | Journal of Clinical Investigation | 2006 | 3,012 |
| 29 | Narcolepsy in orexin Knockout Mice | Cell | 1999 | 2,981 |
| 30 | Role of leptin in the neuroendocrine response to fasting | Nature | 1996 | 2,865 |
| 31 | The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Nature Reviews Genetics | 2006 | 2,833 |
| 32 | SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells | Cell | 2005 | 2,815 |
| 33 | SH2 domains recognize specific phosphopeptide sequences | Cell | 1993 | 2,735 |
| 34 | Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) | Infection Control and Hospital Epidemiology | 2010 | 2,716 |
| 35 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,660 |
| 36 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory | Annals of Neurology | 1990 | 2,648 |
| 37 | Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis | Cell | 1996 | 2,592 |
| 38 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism | Cell Metabolism | 2005 | 2,541 |
| 39 | Transcranial direct current stimulation: State of the art 2008 | Brain Stimulation | 2008 | 2,538 |
| 40 | Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway | Nature Medicine | 2000 | 2,506 |
| 41 | Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy | Cell | 2004 | 2,490 |
| 42 | A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts | Hepatology | 2000 | 2,466 |
| 43 | AKT/PKB Signaling: Navigating the Network | Cell | 2017 | 2,454 |
| 44 | Multiscale Entropy Analysis of Complex Physiologic Time Series | Physical Review Letters | 2002 | 2,449 |
| 45 | The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates | Cell | 1996 | 2,432 |
| 46 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth | Nature | 2008 | 2,423 |
| 47 | In vivo near-infrared fluorescence imaging | Current Opinion in Chemical Biology | 2003 | 2,397 |
| 48 | COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up | Journal of the American College of Cardiology | 2020 | 2,392 |
| 49 | A cortical network for directed attention and unilateral neglect | Annals of Neurology | 1981 | 2,361 |
| 50 | Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt | Science | 1997 | 2,322 |
