| # | Title | Journal | Year | Citations |
|---|
| 1 | 5-Fluorouracil: mechanisms of action and clinical strategies | Nature Reviews Cancer | 2003 | 4,015 |
| 2 | Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease | Nature | 2003 | 1,980 |
| 3 | Inhibition and facilitation of nucleic acid amplification | Applied and Environmental Microbiology | 1997 | 1,809 |
| 4 | Cystic fibrosis | Lancet, The | 2016 | 1,309 |
| 5 | Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial | Lancet, The | 2015 | 1,042 |
| 6 | Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial | Lancet, The | 2016 | 791 |
| 7 | Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) | Lancet Oncology, The | 2009 | 738 |
| 8 | Radiation-induced bystander signalling in cancer therapy | Nature Reviews Cancer | 2009 | 703 |
| 9 | Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I | Journal of Experimental Medicine | 2010 | 663 |
| 10 | Detection of oligomeric forms of α‐synuclein protein in human plasma as a potential biomarker for Parkinson's disease | FASEB Journal | 2006 | 646 |
| 11 | A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment | Cancer | 2007 | 559 |
| 12 | α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma | FASEB Journal | 2003 | 520 |
| 13 | Malignant obstruction of the left colon | British Journal of Surgery | 2005 | 460 |
| 14 | Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus | Diabetes | 2004 | 447 |
| 15 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 16 | Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group | British Journal of Dermatology | 2002 | 444 |
| 17 | Detection of Prosthetic Hip Infection at Revision Arthroplasty by Immunofluorescence Microscopy and PCR Amplification of the Bacterial 16S rRNA Gene | Journal of Clinical Microbiology | 1999 | 436 |
| 18 | Guidelines for topical photodynamic therapy: update | British Journal of Dermatology | 2008 | 433 |
| 19 | Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2015 | 433 |
| 20 | Implications of endotracheal tube biofilm for ventilator-associated pneumonia | Intensive Care Medicine | 1999 | 432 |
| 21 | Upper Airway Collapsibility in Snorers and in Patients with Obstructive Hypopnea and Apnea | The American Review of Respiratory Disease | 1991 | 413 |
| 22 | British Association of Dermatologists’ guidelines for biologic interventions for psoriasis 2009 | British Journal of Dermatology | 2009 | 412 |
| 23 | EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations | Leukemia | 2012 | 409 |
| 24 | X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment | Nature Genetics | 2008 | 397 |
| 25 | Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer – Results from two randomised studies | European Journal of Cancer | 2010 | 395 |
| 26 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 27 | Campylobacter | Veterinary Research | 2005 | 389 |
| 28 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes | Current Microbiology | 2010 | 386 |
| 29 | BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis | Cancer Research | 2003 | 339 |
| 30 | Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments | FEBS Letters | 1998 | 329 |
| 31 | PAD combination therapy (PS‐341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma | British Journal of Haematology | 2005 | 313 |
| 32 | Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation | British Journal of Anaesthesia | 2018 | 313 |
| 33 | Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial | Lancet, The | 2021 | 313 |
| 34 | Factors influencing success of clinical genome sequencing across a broad spectrum of disorders | Nature Genetics | 2015 | 310 |
| 35 | Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis | Intensive Care Medicine | 2017 | 305 |
| 36 | Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years | British Journal of Surgery | 2017 | 304 |
| 37 | Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial | Lancet Oncology, The | 2014 | 296 |
| 38 | Mutations ofARX are associated with striking pleiotropy and consistent genotype-phenotype correlation | Human Mutation | 2004 | 293 |
| 39 | A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 292 |
| 40 | A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis | New England Journal of Medicine | 2008 | 287 |
| 41 | Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability | Nature Genetics | 2014 | 280 |
| 42 | Psychosocial impact of breast/ovarian (BRCA 1/2) cancer-predictive genetic testing in a UK multi-centre clinical cohort | British Journal of Cancer | 2004 | 276 |
| 43 | Ocular Pathogen or Commensal: A PCR-Based Study of Surface Bacterial Flora in Normal and Dry Eyes | | 2007 | 269 |
| 44 | The Hybrid Algorithm for Treating Chronic Total Occlusions in Europe | Journal of the American College of Cardiology | 2016 | 256 |
| 45 | Guideline for investigation and management of adults and children presenting with a thrombocytosis | British Journal of Haematology | 2010 | 253 |
| 46 | Primary synovial chondromatosis: A clinicopathologic review and assessment of malignant potential | Human Pathology | 1998 | 247 |
| 47 | Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma [published erratum appears in Hum Mol Genet 1999 May;8(5):943] | Human Molecular Genetics | 1999 | 245 |
| 48 | CD44 Potentiates the Adherence of Metastatic Prostate and Breast Cancer Cells to Bone Marrow Endothelial Cells | Cancer Research | 2004 | 245 |
| 49 | British Association of Dermatologists guidelines for use of biological interventions in psoriasis 2005 | British Journal of Dermatology | 2005 | 245 |
| 50 | Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3 | Nature Genetics | 2013 | 242 |
