| # | Title | Journal | Year | Citations |
|---|
| 1 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 2 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 | Intensive Care Medicine | 2013 | 3,906 |
| 3 | The Influence of Inadequate Antimicrobial Treatment of Bloodstream Infections on Patient Outcomes in the ICU Setting | Chest | 2000 | 1,641 |
| 4 | Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: | Journal of Parenteral and Enteral Nutrition | 2009 | 1,461 |
| 5 | Bacterial Adhesion: Seen Any Good Biofilms Lately? | Clinical Microbiology Reviews | 2002 | 1,211 |
| 6 | A brain–computer interface using electrocorticographic signals in humans | Journal of Neural Engineering | 2004 | 1,066 |
| 7 | Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α | Nature | 1996 | 1,064 |
| 8 | Surgical site infection: Incidence and impact on hospital utilization and treatment costs | American Journal of Infection Control | 2009 | 957 |
| 9 | The Use of Continuous IV Sedation Is Associated With Prolongation of Mechanical Ventilation | Chest | 1998 | 920 |
| 10 | Clinical Importance of Delays in the Initiation of Appropriate Antibiotic Treatment for Ventilator-Associated Pneumonia | Chest | 2002 | 912 |
| 11 | Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1 | Journal of Experimental Medicine | 2001 | 845 |
| 12 | Extended Mechanical Circulatory Support With a Continuous-Flow Rotary Left Ventricular Assist Device | Journal of the American College of Cardiology | 2009 | 825 |
| 13 | HEMOGLOBIN METABOLISM IN THE MALARIA PARASITEPLASMODIUM FALCIPARUM | Annual Review of Microbiology | 1997 | 721 |
| 14 | The Demographic and Morphological Features of Rotator Cuff Disease | Journal of Bone and Joint Surgery - Series A | 2006 | 678 |
| 15 | Rabbit Antithymocyte Globulin versus Basiliximab in Renal Transplantation | New England Journal of Medicine | 2006 | 675 |
| 16 | Recognition of a virus-encoded ligand by a natural killer cell activation receptor | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 673 |
| 17 | Matrix metalloproteinase degradation of extracellular matrix: biological consequences | Current Opinion in Cell Biology | 1998 | 648 |
| 18 | Risk Factors for Surgical Site Infection Following Orthopaedic Spinal Operations | Journal of Bone and Joint Surgery - Series A | 2008 | 630 |
| 19 | Incidence of BK with Tacrolimus Versus Cyclosporine and Impact of Preemptive Immunosuppression Reduction | American Journal of Transplantation | 2005 | 613 |
| 20 | Autonomic Nervous System Responses during Sedative Infusions of Dexmedetomidine | Anesthesiology | 2002 | 601 |
| 21 | Protein transduction: unrestricted delivery into all cells? | Trends in Cell Biology | 2000 | 557 |
| 22 | Natural history of asymptomatic rotator cuff tears: A longitudinal analysis of asymptomatic tears detected sonographically | Journal of Shoulder and Elbow Surgery | 2001 | 554 |
| 23 | Inadequate Antimicrobial Treatment: An Important Determinant of Outcome for Hospitalized Patients | Clinical Infectious Diseases | 2000 | 553 |
| 24 | The Cox maze III procedure for atrial fibrillation: long-term efficacy in patients undergoing lone versus concomitant procedures | Journal of Thoracic and Cardiovascular Surgery | 2003 | 542 |
| 25 | In vivo developmental stages in murine natural killer cell maturation | Nature Immunology | 2002 | 536 |
| 26 | Immune functions encoded by the natural killer gene complex | Nature Reviews Immunology | 2003 | 529 |
| 27 | Pseudomonas aeruginosa Bloodstream Infection: Importance of Appropriate Initial Antimicrobial Treatment | Antimicrobial Agents and Chemotherapy | 2005 | 485 |
| 28 | INSIGHTS FROM THE STUDY OF HEART RATE VARIABILITY | Annual Review of Medicine | 1999 | 473 |
| 29 | Decoding two-dimensional movement trajectories using electrocorticographic signals in humans | Journal of Neural Engineering | 2007 | 456 |
| 30 | DGIdb: mining the druggable genome | Nature Methods | 2013 | 443 |
| 31 | Characteristics and circumstances of falls in a hospital setting | Journal of General Internal Medicine | 2004 | 425 |
| 32 | Evolution of vascular fellowship training in the new era of endovascular techniques | Journal of Vascular Surgery | 2001 | 424 |
| 33 | Before–after study of a standardized hospital order set for the management of septic shock* | Critical Care Medicine | 2006 | 424 |
| 34 | Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections | International Journal of Antimicrobial Agents | 2008 | 407 |
| 35 | Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction | Sports Health | 2011 | 406 |
| 36 | SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution | PLoS Computational Biology | 2014 | 400 |
| 37 | A Randomized Clinical Trial Comparing an Extended-Use Hygroscopic Condenser Humidifier With Heated-Water Humidification in Mechanically Ventilated Patients | Chest | 1998 | 384 |
| 38 | NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation | Nature Immunology | 2002 | 380 |
| 39 | Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer | Journal of Immunology | 2009 | 377 |
| 40 | Septic Shock Attributed to Candida Infection: Importance of Empiric Therapy and Source Control | Clinical Infectious Diseases | 2012 | 377 |
| 41 | Prevention and early detection of prostate cancer | Lancet Oncology, The | 2014 | 372 |
| 42 | Health Care-Associated Pneumonia and Community-Acquired Pneumonia: a Single-Center Experience | Antimicrobial Agents and Chemotherapy | 2007 | 367 |
| 43 | Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction | Journal of Cell Biology | 2000 | 357 |
| 44 | A Randomized Controlled Trial of an Antibiotic Discontinuation Policy for Clinically Suspected Ventilator-Associated Pneumonia | Chest | 2004 | 349 |
| 45 | Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 346 |
| 46 | CONGESTIVE HEART FAILURE IN OLDER ADULTS*: Epidemiology, Pathophysiology, and Etiology of Congestive Heart Failure in Older Adults | Journal of the American Geriatrics Society | 1997 | 334 |
| 47 | Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality | Shock | 2014 | 324 |
| 48 | PEDICLE SUBTRACTION OSTEOTOMY FOR THE TREATMENT OF FIXED SAGITTAL IMBALANCE | Journal of Bone and Joint Surgery - Series A | 2003 | 322 |
| 49 | The Occurrence of Ventilator-Associated Pneumonia in a Community Hospital | Chest | 2001 | 310 |
| 50 | Factors Affecting Healing Rates after Arthroscopic Double-Row Rotator Cuff Repair | American Journal of Sports Medicine | 2010 | 307 |
