| # | Title | Journal | Year | Citations |
|---|
| 1 | Trim and Fill: A Simple Funnel-Plot-Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis | Biometrics | 2000 | 10,009 |
| 2 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 6,039 |
| 3 | Acute-Phase Proteins and Other Systemic Responses to Inflammation | New England Journal of Medicine | 1999 | 5,677 |
| 4 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Critical Care Medicine | 2003 | 5,266 |
| 5 | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure | New England Journal of Medicine | 2004 | 5,193 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 7 | PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY | Journal of Histochemistry and Cytochemistry | 1974 | 3,903 |
| 8 | HMG-1 as a Late Mediator of Endotoxin Lethality in Mice | Science | 1999 | 3,807 |
| 9 | Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases | Science | 2002 | 3,738 |
| 10 | ACUTE RESPIRATORY DISTRESS IN ADULTS | Lancet, The | 1967 | 3,160 |
| 11 | Recommended standards for reports dealing with lower extremity ischemia: Revised version | Journal of Vascular Surgery | 1997 | 3,094 |
| 12 | The metabolic syndrome | Lancet, The | 2010 | 2,488 |
| 13 | PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATION | Journal of Histochemistry and Cytochemistry | 1974 | 2,471 |
| 14 | Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis | Annals of Neurology | 1996 | 2,365 |
| 15 | CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells | Journal of Experimental Medicine | 2006 | 2,292 |
| 16 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus | Nature | 2009 | 2,001 |
| 17 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Intensive Care Medicine | 2003 | 1,965 |
| 18 | Obesity and the Environment: Where Do We Go from Here? | Science | 2003 | 1,881 |
| 19 | The staphylococcal enterotoxins and their relatives | Science | 1990 | 1,875 |
| 20 | Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce | Thyroid | 2006 | 1,857 |
| 21 | Environmental Contributions to the Obesity Epidemic | Science | 1998 | 1,829 |
| 22 | 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines | Annals of Thoracic Surgery | 2011 | 1,733 |
| 23 | Proinflammatory Cytokines | Chest | 2000 | 1,692 |
| 24 | Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura | Nature | 2001 | 1,623 |
| 25 | Language of Early- and Later-identified Children With Hearing Loss | Pediatrics | 1998 | 1,610 |
| 26 | Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America | MMWR Recommendations and Reports | 2004 | 1,578 |
| 27 | The Care Transitions Intervention | Archives of Internal Medicine | 2006 | 1,574 |
| 28 | ACTION OF X-RAYS ON MAMMALIAN CELLS | Journal of Experimental Medicine | 1956 | 1,562 |
| 29 | The genome sequence of the filamentous fungus Neurospora crassa | Nature | 2003 | 1,528 |
| 30 | Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer | Journal of the National Cancer Institute | 2005 | 1,517 |
| 31 | Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome | Nature Genetics | 2001 | 1,488 |
| 32 | ELECTRICAL WIRING CONFIGURATIONS AND CHILDHOOD CANCER | American Journal of Epidemiology | 1979 | 1,477 |
| 33 | Increasing response rates to postal questionnaires: systematic review | BMJ: British Medical Journal | 2002 | 1,428 |
| 34 | Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study | Lancet, The | 2001 | 1,421 |
| 35 | The Role and Regulation of Adenosine in the Central Nervous System | Annual Review of Neuroscience | 2001 | 1,410 |
| 36 | Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein | Journal of Biological Chemistry | 2004 | 1,397 |
| 37 | INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION | Pediatrics | 1963 | 1,397 |
| 38 | Drotrecogin Alfa (Activated) for Adults with Severe Sepsis and a Low Risk of Death | New England Journal of Medicine | 2005 | 1,364 |
| 39 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
| 40 | Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes | Diabetes Care | 2011 | 1,342 |
| 41 | Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis | Journal of Clinical Oncology | 2003 | 1,333 |
| 42 | Executive Function Deficits in High-Functioning Autistic Individuals: Relationship to Theory of Mind | Journal of Child Psychology and Psychiatry and Allied Disciplines | 1991 | 1,313 |
| 43 | Fine structural localization of glutamine synthetase in astrocytes of rat brain | Brain Research | 1979 | 1,296 |
| 44 | Human bone marrow colony growth in agar-gel | Journal of Cellular Physiology | 1970 | 1,270 |
| 45 | Independent Association between Acute Renal Failure and Mortality following Cardiac Surgery 11Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/22The VA Continuous Improvement in Cardiac Surgery Program was initially supported by the Health Services Research and Development Service, Veterans Health Administration, and funded through VA Patient Care Services. | American Journal of Medicine | 1998 | 1,252 |
| 46 | Type 1 diabetes: new perspectives on disease pathogenesis and treatment | Lancet, The | 2001 | 1,244 |
| 47 | Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte | Cell | 2005 | 1,225 |
| 48 | Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors | Nature | 1997 | 1,201 |
| 49 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 50 | Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation | Pharmaceutical Research | 2003 | 1,179 |
