| # | Title | Journal | Year | Citations |
|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 16,554 |
| 2 | Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance | Clinical Microbiology and Infection | 2012 | 8,996 |
| 3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 4 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 5 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Critical Care Medicine | 2003 | 5,266 |
| 6 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 7 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 | Intensive Care Medicine | 2013 | 3,906 |
| 8 | Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease | New England Journal of Medicine | 2012 | 3,005 |
| 9 | Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2009 | 2,904 |
| 10 | Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria | Lancet Neurology, The | 2014 | 2,657 |
| 11 | Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Journal of Extracellular Vesicles | 2014 | 2,110 |
| 12 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock | Intensive Care Medicine | 2004 | 2,079 |
| 13 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Intensive Care Medicine | 2003 | 1,965 |
| 14 | The Children's Sleep Habits Questionnaire (CSHQ): Psychometric Properties of A Survey Instrument for School-Aged Children | Sleep | 2000 | 1,688 |
| 15 | Developing a New Definition and Assessing New Clinical Criteria for Septic Shock | JAMA - Journal of the American Medical Association | 2016 | 1,622 |
| 16 | Self-Efficacy and the Stages of Exercise Behavior Change | Research Quarterly for Exercise and Sport | 1992 | 1,441 |
| 17 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 18 | Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study | Lancet, The | 2020 | 1,395 |
| 19 | Guidelines for the Management of Intravascular Catheter-Related Infections | Clinical Infectious Diseases | 2001 | 1,354 |
| 20 | Anti-Inflammatory Cytokines | Chest | 2000 | 1,320 |
| 21 | Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells | Endocrinology | 2005 | 1,254 |
| 22 | High-Dose Antithrombin III in Severe Sepsis | JAMA - Journal of the American Medical Association | 2001 | 1,240 |
| 23 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis | Intensive Care Medicine | 2010 | 1,180 |
| 24 | Delirium in the Intensive Care Unit: Occurrence and Clinical Course in Older Patients | Journal of the American Geriatrics Society | 2003 | 1,120 |
| 25 | The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis* | Critical Care Medicine | 2010 | 1,094 |
| 26 | ACG Clinical Guideline: Treatment of Helicobacter pylori Infection | American Journal of Gastroenterology | 2017 | 1,084 |
| 27 | Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis | Hepatology | 2010 | 1,078 |
| 28 | Management of Thyroid Nodules Detected at US: Society of Radiologists in Ultrasound Consensus Conference Statement | Radiology | 2005 | 1,055 |
| 29 | Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder | American Journal of Human Genetics | 2006 | 1,032 |
| 30 | Blood Transfusion in Elderly Patients with Acute Myocardial Infarction | New England Journal of Medicine | 2001 | 982 |
| 31 | Antiretroviral Therapy in Adults | JAMA - Journal of the American Medical Association | 2000 | 951 |
| 32 | Analysis of Missed Cases of Abusive Head Trauma | JAMA - Journal of the American Medical Association | 1999 | 920 |
| 33 | Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice | Journal of Leukocyte Biology | 2008 | 913 |
| 34 | Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults | JAMA Pediatrics | 2017 | 893 |
| 35 | Pioglitazone after Ischemic Stroke or Transient Ischemic Attack | New England Journal of Medicine | 2016 | 877 |
| 36 | Change in End-of-Life Care for Medicare Beneficiaries | JAMA - Journal of the American Medical Association | 2013 | 834 |
| 37 | Prevention of Intravascular Catheter–Related Infections | Annals of Internal Medicine | 2000 | 819 |
| 38 | Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium | Clinical Infectious Diseases | 2013 | 792 |
| 39 | Patients’ use of the internet for medical information | Journal of General Internal Medicine | 2002 | 783 |
| 40 | Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives | European Respiratory Journal | 2019 | 776 |
| 41 | Managing Incidental Findings on Abdominal CT: White Paper of the ACR Incidental Findings Committee | Journal of the American College of Radiology | 2010 | 766 |
| 42 | Antiretroviral Therapy for HIV Infection in 1998 | JAMA - Journal of the American Medical Association | 1998 | 764 |
| 43 | Recurrence After Recovery From Major Depressive Disorder During 15 Years of Observational Follow-Up | American Journal of Psychiatry | 1999 | 689 |
| 44 | Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry | Science | 2008 | 688 |
| 45 | Classification and regression tree analysis in public health: Methodological review and comparison with logistic regression | Annals of Behavioral Medicine | 2003 | 685 |
| 46 | A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease | Neurology | 2009 | 677 |
| 47 | Adolescent Sleep Patterns, Circadian Timing, and Sleepiness at a Transition to Early School Days | Sleep | 1998 | 650 |
| 48 | Donanemab in Early Alzheimer’s Disease | New England Journal of Medicine | 2021 | 633 |
| 49 | Multivariate assessment of conflict in distressed and nondistressed mother-adolescent dyads | Journal of Applied Behavior Analysis | 1979 | 630 |
| 50 | Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives | Genetics in Medicine | 2009 | 629 |
