| # | Title | Journal | Year | Citations |
|---|
| 1 | International uniform response criteria for multiple myeloma | Leukemia | 2006 | 2,332 |
| 2 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 3 | Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial | Lancet, The | 2018 | 901 |
| 4 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2013 | 710 |
| 5 | International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders | Leukemia | 2009 | 686 |
| 6 | Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial | BMJ: British Medical Journal | 2008 | 617 |
| 7 | The who, where, and what of rapid sequence intubation: prospective observational study of emergency RSI outside the operating theatre | Emergency Medicine Journal | 2004 | 599 |
| 8 | Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial | American Journal of Medicine | 2015 | 480 |
| 9 | International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma | Leukemia | 2009 | 428 |
| 10 | Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria | Nutrients | 2015 | 423 |
| 11 | Gait Speed as a Measure in Geriatric Assessment in Clinical Settings: A Systematic Review | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2013 | 413 |
| 12 | Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men | Diabetologia | 2010 | 405 |
| 13 | Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer | New England Journal of Medicine | 2019 | 403 |
| 14 | Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study | Lancet, The | 2020 | 394 |
| 15 | Knee osteoarthritis and obesity | International Journal of Obesity | 2001 | 374 |
| 16 | Hypoxic-ischemic encephalopathy in term neonates: Perinatal factors and outcome | Journal of Pediatrics | 1981 | 359 |
| 17 | Prevalence and Risk Factors for Diabetic Retinopathy | Ophthalmology | 2008 | 354 |
| 18 | Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019 | JAMA Network Open | 2020 | 344 |
| 19 | Epidemiology of acromegaly | JAMA Network Open | 1999 | 339 |
| 20 | Diagnosis of monoclonal gammopathy of renal significance | Kidney International | 2015 | 339 |
| 21 | The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group | Nature Reviews Nephrology | 2019 | 330 |
| 22 | Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial | Lancet Oncology, The | 2020 | 324 |
| 23 | Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial | Lancet Oncology, The | 2017 | 320 |
| 24 | Guidelines on the management of acute respiratory distress syndrome | BMJ Open Respiratory Research | 2019 | 316 |
| 25 | Development of a dedicated risk-adjustment scoring system for colorectal surgery (colorectal POSSUM) | British Journal of Surgery | 2004 | 313 |
| 26 | Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial | Lancet, The | 2021 | 313 |
| 27 | Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics | BMJ, The | 2012 | 282 |
| 28 | Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial | Lancet Oncology, The | 2014 | 279 |
| 29 | Association Between Obesity and Mortality After Acute First-Ever Stroke | Stroke | 2011 | 277 |
| 30 | Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries | European Heart Journal | 2014 | 275 |
| 31 | In Vitro and In Vivo Inhibition of Helicobacter pylori by Lactobacillus casei Strain Shirota | Applied and Environmental Microbiology | 2004 | 270 |
| 32 | A procedure‐specific systematic review and consensus recommendations for postoperative analgesia following total knee arthroplasty | Anaesthesia | 2008 | 262 |
| 33 | Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial | Annals of Oncology | 2019 | 262 |
| 34 | Nurses' Moral Sensitivity and Hospital Ethical Climate: a Literature Review | Nursing Ethics | 2008 | 261 |
| 35 | How I treat monoclonal gammopathy of renal significance (MGRS) | Blood | 2013 | 259 |
| 36 | Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection | Journal of Experimental Medicine | 2021 | 259 |
| 37 | Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient data | Lancet Oncology, The | 2014 | 256 |
| 38 | Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2 | MBio | 2020 | 245 |
| 39 | Consensus in chronic ankle instability: Aetiology, assessment, surgical indications and place for arthroscopy | Orthopaedics and Traumatology: Surgery and Research | 2013 | 240 |
| 40 | The incidence of irreversible retinal toxicity in patients treated with hydroxychloroquine | Ophthalmology | 2003 | 236 |
| 41 | Bisphosphonate-associated adverse events | Hormones | 2009 | 231 |
| 42 | A Molecular Classification of Papillary Renal Cell Carcinoma | Cancer Research | 2005 | 226 |
| 43 | Loss of Parafibromin Immunoreactivity Is a Distinguishing Feature of Parathyroid Carcinoma | Clinical Cancer Research | 2004 | 223 |
| 44 | White-coat and masked hypertension in children: association with target-organ damage | Pediatric Nephrology | 2005 | 222 |
| 45 | Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation | Nature Medicine | 2016 | 222 |
| 46 | Taxane resistance in breast cancer: Mechanisms, predictive biomarkers and circumvention strategies | Cancer Treatment Reviews | 2012 | 221 |
| 47 | Determinants of burnout and other aspects of psychological well-being in healthcare workers during the Covid-19 pandemic: A multinational cross-sectional study | PLoS ONE | 2021 | 215 |
| 48 | Eicosapentaenoic acid (EPA) from highly concentrated n−3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability | Atherosclerosis | 2010 | 214 |
| 49 | Impact of Obesity on 24-Hour Ambulatory Blood Pressure and Hypertension | Hypertension | 2005 | 213 |
| 50 | Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies | Lipids in Health and Disease | 2011 | 213 |
