| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing | Nature Biotechnology | 2013 | 1,785 |
| 3 | Cisplatin, Radiation, and Adjuvant Hysterectomy Compared with Radiation and Adjuvant Hysterectomy for Bulky Stage IB Cervical Carcinoma | New England Journal of Medicine | 1999 | 1,734 |
| 4 | The establishment of polarity by hippocampal neurons in culture | Journal of Neuroscience | 1988 | 1,715 |
| 5 | A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study | Gynecologic Oncology | 2004 | 1,531 |
| 6 | ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY | Lancet, The | 1972 | 1,508 |
| 7 | Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells | Science | 2004 | 1,403 |
| 8 | The development of neural stem cells | Nature | 2001 | 1,389 |
| 9 | The Efficacy of Surgical Modifications of the Upper Airway in Adults With Obstructive Sleep Apnea Syndrome | Sleep | 1996 | 1,127 |
| 10 | Molecular Aspects of Thyroid Hormone Actions | Endocrine Reviews | 2010 | 1,102 |
| 11 | HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis | Heart Rhythm | 2014 | 1,077 |
| 12 | Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma | Cancer | 1996 | 1,010 |
| 13 | Effects of Coenzyme Q10 in Early Parkinson Disease | Archives of Neurology | 2002 | 994 |
| 14 | The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti–HER-2 Therapy and Personalized Medicine | Oncologist | 2009 | 986 |
| 15 | IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial | Annals of the Rheumatic Diseases | 2008 | 951 |
| 16 | Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation | Hepatology | 2000 | 945 |
| 17 | Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis | New England Journal of Medicine | 2012 | 826 |
| 18 | Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials | Journal of Clinical Oncology | 2008 | 781 |
| 19 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 780 |
| 20 | Timing of CNS Cell Generation | Neuron | 2000 | 770 |
| 21 | Deglycosylation of glycoproteins by trifluoromethanesulfonic acid | Analytical Biochemistry | 1981 | 762 |
| 22 | The NLR Gene Family: A Standard Nomenclature | Immunity | 2008 | 761 |
| 23 | Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies | Nature | 2002 | 747 |
| 24 | Control Selection for RNA Quantitation | BioTechniques | 2000 | 730 |
| 25 | Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial | Clinical Infectious Diseases | 2007 | 724 |
| 26 | The Incidence of Pediatric Cardiomyopathy in Two Regions of the United States | New England Journal of Medicine | 2003 | 722 |
| 27 | The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy | Stem Cells | 1998 | 704 |
| 28 | Vancomycin Therapeutic Guidelines: A Summary of Consensus Recommendations from the Infectious Diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists | Clinical Infectious Diseases | 2009 | 702 |
| 29 | Trophic interactions between astroglial cells and hippocampal neurons in culture | Science | 1980 | 699 |
| 30 | Global epidemiology and outcomes of acute kidney injury | Nature Reviews Nephrology | 2018 | 698 |
| 31 | Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures | Journal of Neuroscience | 1990 | 673 |
| 32 | Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review | Lancet Infectious Diseases, The | 2006 | 649 |
| 33 | Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome | Movement Disorders | 2017 | 649 |
| 34 | LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal | Neuron | 2002 | 644 |
| 35 | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint radiation therapy oncology group and eastern cooperative oncology group study | Cancer | 1983 | 595 |
| 36 | Methotrexate for Rheumatoid Arthritis | Arthritis and Rheumatism | 1994 | 594 |
| 37 | Efficacy of an Elective Regional Lymph Node Dissection of 1 to 4 mm Thick Melanomas for Patients 60 Years of Age and Younger | Annals of Surgery | 1996 | 591 |
| 38 | Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States | JAMA - Journal of the American Medical Association | 2014 | 586 |
| 39 | Topographically Distinct Epidermal Nociceptive Circuits Revealed by Axonal Tracers Targeted to Mrgprd | Neuron | 2005 | 575 |
| 40 | Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial | Arthritis and Rheumatism | 2002 | 570 |
| 41 | Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria | Nature Immunology | 2006 | 567 |
| 42 | The HER‐2/ neu Gene and Protein in Breast Cancer 2003: Biomarker and Target of Therapy | Oncologist | 2003 | 561 |
| 43 | Pharmacodynamics of Levofloxacin | JAMA - Journal of the American Medical Association | 1998 | 554 |
| 44 | A self-renewing multipotential stem cell in embryonic rat cerebral cortex | Nature | 1994 | 548 |
| 45 | Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection | Ophthalmology | 2003 | 541 |
| 46 | Raising awareness of acute kidney injury: a global perspective of a silent killer | Kidney International | 2013 | 541 |
| 47 | The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells | Nature Neuroscience | 2006 | 540 |
| 48 | Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents | Life Sciences | 1984 | 539 |
| 49 | Opioid Metabolism | Mayo Clinic Proceedings | 2009 | 537 |
| 50 | Signal transduction by focal adhesion kinase in cancer | Cancer and Metastasis Reviews | 2009 | 529 |
