| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,847 |
| 2 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 2,117 |
| 3 | Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing | Nature Biotechnology | 2013 | 1,885 |
| 4 | Cisplatin, Radiation, and Adjuvant Hysterectomy Compared with Radiation and Adjuvant Hysterectomy for Bulky Stage IB Cervical Carcinoma | New England Journal of Medicine | 1999 | 1,766 |
| 5 | The establishment of polarity by hippocampal neurons in culture | Journal of Neuroscience | 1988 | 1,756 |
| 6 | Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy | Clinical Cancer Research | 2005 | 1,654 |
| 7 | A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study | Gynecologic Oncology | 2004 | 1,572 |
| 8 | Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists | American Journal of Health-System Pharmacy | 2009 | 1,549 |
| 9 | 2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease‐modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis | Arthritis Care and Research | 2012 | 1,531 |
| 10 | ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY | Lancet, The | 1972 | 1,513 |
| 11 | Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells | Science | 2004 | 1,419 |
| 12 | The development of neural stem cells | Nature | 2001 | 1,401 |
| 13 | HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis | Heart Rhythm | 2014 | 1,191 |
| 14 | The Efficacy of Surgical Modifications of the Upper Airway in Adults With Obstructive Sleep Apnea Syndrome | Sleep | 1996 | 1,171 |
| 15 | Molecular Aspects of Thyroid Hormone Actions | Endocrine Reviews | 2010 | 1,158 |
| 16 | World Incidence of AKI | Clinical Journal of the American Society of Nephrology: CJASN | 2013 | 1,149 |
| 17 | Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma | Cancer | 1996 | 1,034 |
| 18 | The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti–HER-2 Therapy and Personalized Medicine | Oncologist | 2009 | 1,014 |
| 19 | IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial | Annals of the Rheumatic Diseases | 2008 | 975 |
| 20 | Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions | Cell Stem Cell | 2008 | 964 |
| 21 | Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation | Hepatology | 2000 | 953 |
| 22 | Global epidemiology and outcomes of acute kidney injury | Nature Reviews Nephrology | 2018 | 878 |
| 23 | International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology | Lancet, The | 2015 | 869 |
| 24 | Oxidative stress: the paradox of aerobic life | Biochemical Society Symposia | 1995 | 866 |
| 25 | Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device | Nature Biotechnology | 2002 | 851 |
| 26 | The NLR Gene Family: A Standard Nomenclature | Immunity | 2008 | 812 |
| 27 | Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies | Nature Medicine | 2012 | 806 |
| 28 | Timing of CNS Cell Generation | Neuron | 2000 | 785 |
| 29 | Therapeutic monitoring of vancomycin for serious methicillin-resistantStaphylococcus aureusinfections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists | American Journal of Health-System Pharmacy | 2020 | 763 |
| 30 | Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophies | Nature | 2002 | 754 |
| 31 | Control Selection for RNA Quantitation | BioTechniques | 2000 | 743 |
| 32 | Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial | Clinical Infectious Diseases | 2007 | 735 |
| 33 | Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome | Movement Disorders | 2017 | 727 |
| 34 | Vancomycin Therapeutic Guidelines: A Summary of Consensus Recommendations from the Infectious Diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists | Clinical Infectious Diseases | 2009 | 724 |
| 35 | The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy | Stem Cells | 1998 | 718 |
| 36 | Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures | Journal of Neuroscience | 1990 | 676 |
| 37 | Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review | Lancet Infectious Diseases, The | 2006 | 666 |
| 38 | LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal | Neuron | 2002 | 648 |
| 39 | 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis | Arthritis Care and Research | 2021 | 640 |
| 40 | Bone grafts, bone substitutes and orthobiologics | Organogenesis | 2012 | 614 |
| 41 | Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States | JAMA - Journal of the American Medical Association | 2014 | 612 |
| 42 | Raising awareness of acute kidney injury: a global perspective of a silent killer | Kidney International | 2013 | 603 |
| 43 | Methotrexate for Rheumatoid Arthritis | Arthritis and Rheumatism | 1994 | 599 |
| 44 | Topographically Distinct Epidermal Nociceptive Circuits Revealed by Axonal Tracers Targeted to Mrgprd | Neuron | 2005 | 599 |
| 45 | Results of PREVENT III: A multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery | Journal of Vascular Surgery | 2006 | 599 |
| 46 | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint radiation therapy oncology group and eastern cooperative oncology group study | Cancer | 1983 | 598 |
| 47 | Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria | Nature Immunology | 2006 | 581 |
| 48 | Opioid Metabolism | Mayo Clinic Proceedings | 2009 | 578 |
| 49 | Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin‐1 receptor antagonist, in combination with methotrexate: Results of a twenty‐four–week, multicenter, randomized, double‐blind, placebo‐controlled trial | Arthritis and Rheumatism | 2002 | 576 |
| 50 | The HER-2/neu Gene and Protein in Breast Cancer 2003: Biomarker and Target of Therapy | Oncologist | 2003 | 572 |
