| # | Title | Journal | Year | Citations |
|---|
| 1 | Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer | New England Journal of Medicine | 2017 | 2,631 |
| 2 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial | Lancet Oncology, The | 2008 | 1,667 |
| 3 | Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials | Lancet Oncology, The | 2015 | 1,369 |
| 4 | Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus | Journal of Diabetes Investigation | 2010 | 1,206 |
| 5 | The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification | Kidney International | 2009 | 1,028 |
| 6 | The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility | Kidney International | 2009 | 892 |
| 7 | Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6 | Lancet Oncology, The | 2015 | 786 |
| 8 | Assessment of Culprit Lesion Morphology in Acute Myocardial Infarction | Journal of the American College of Cardiology | 2007 | 784 |
| 9 | Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators | Nature Genetics | 2012 | 781 |
| 10 | International Consensus Guidance Statement on the Management and Treatment of IgG4‐Related Disease | Arthritis and Rheumatology | 2015 | 767 |
| 11 | Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial | Lancet, The | 2017 | 753 |
| 12 | A defined commensal consortium elicits CD8 T cells and anti-cancer immunity | Nature | 2019 | 741 |
| 13 | International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values | Journal of Diabetes Investigation | 2012 | 731 |
| 14 | Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma | Cancer Cell | 2016 | 717 |
| 15 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus | Nature Genetics | 2008 | 694 |
| 16 | Effects of <b><i>Aloe</i></b> Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial | Skin Pharmacology and Physiology | 2016 | 685 |
| 17 | Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study | Lancet Oncology, The | 2014 | 678 |
| 18 | Antibodies to adult t-cell leukemia-virus-associated antigen (atla) in sera from patients with atl and controls in japan: A nation-wide sero-epidemiologic study | International Journal of Cancer | 1982 | 612 |
| 19 | Anemia management and outcomes from 12 countries in the dialysis outcomes and practice patterns study (DOPPS) | American Journal of Kidney Diseases | 2004 | 600 |
| 20 | Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer | Nature Genetics | 2016 | 596 |
| 21 | High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk | Clinical Cancer Research | 2006 | 581 |
| 22 | A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen | Journal of Human Hypertension | 2002 | 541 |
| 23 | Poorly Differentiated Thyroid Carcinoma: The Turin Proposal for the Use of Uniform Diagnostic Criteria and an Algorithmic Diagnostic Approach | American Journal of Surgical Pathology | 2007 | 521 |
| 24 | Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation (ILUMIEN III: OPTIMIZE PCI): a randomised controlled trial | Lancet, The | 2016 | 473 |
| 25 | Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer | International Journal of Cancer | 2004 | 472 |
| 26 | Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion | Journal of Biological Chemistry | 2004 | 462 |
| 27 | Assessment of Coronary Arterial Thrombus by Optical Coherence Tomography | American Journal of Cardiology | 2006 | 433 |
| 28 | Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers | International Journal of Cancer | 2011 | 420 |
| 29 | Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. | Journal of Biological Chemistry | 1988 | 418 |
| 30 | Frequency-Dependent Natural Selection in the Handedness of Scale-Eating Cichlid Fish | Science | 1993 | 405 |
| 31 | Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction | Journal of Clinical Investigation | 2003 | 402 |
| 32 | Early Removal of Prophylactic Drains Reduces the Risk of Intra-abdominal Infections in Patients With Pancreatic Head Resection | Annals of Surgery | 2006 | 400 |
| 33 | Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2017 | 398 |
| 34 | Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study | Kidney International | 2006 | 387 |
| 35 | Genetic variants of IL-13 signalling and human asthma and atopy | Human Molecular Genetics | 2000 | 383 |
| 36 | Kabuki make-up (Niikawa-Kuroki) syndrome: A study of 62 patients | American Journal of Medical Genetics Part A | 1988 | 373 |
| 37 | Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells | Cancer Research | 2010 | 354 |
| 38 | Assessment of Coronary Arterial Plaque by Optical Coherence Tomography | American Journal of Cardiology | 2006 | 353 |
| 39 | Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures | European Heart Journal | 2012 | 349 |
| 40 | Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction | Journal of the American College of Cardiology | 2009 | 345 |
| 41 | Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity | Journal of Biological Chemistry | 1988 | 343 |
| 42 | Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study | Osteoarthritis and Cartilage | 2014 | 339 |
| 43 | Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05) | Japanese Journal of Clinical Oncology | 2019 | 329 |
| 44 | Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial | Lancet, The | 2014 | 326 |
| 45 | JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome | Circulation Journal | 2019 | 324 |
| 46 | Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study | Osteoarthritis and Cartilage | 2009 | 323 |
| 47 | Report of the Committee on the classification and diagnostic criteria of diabetes mellitus | Diabetology International | 2010 | 322 |
| 48 | Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis | Cytokine and Growth Factor Reviews | 2006 | 317 |
| 49 | Diagnostic Criteria, Clinical Features, and Incidence of Thyroid Storm Based on Nationwide Surveys | Thyroid | 2012 | 315 |
| 50 | Correlation between immune-related adverse events and efficacy in non-small cell lung cancer treated with nivolumab | Lung Cancer | 2018 | 313 |
