| # | Title | Journal | Year | Citations |
|---|
| 1 | Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial | Lancet, The | 2016 | 5,456 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 4 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 5 | Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial | Lancet, The | 2017 | 3,224 |
| 6 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 | Journal of the American College of Cardiology | 2017 | 2,705 |
| 7 | Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2012 | 1,752 |
| 8 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 9 | CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer | Nature Genetics | 2006 | 1,715 |
| 10 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 11 | AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer | Cancer Discovery | 2014 | 1,655 |
| 12 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 13 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
| 14 | COVID-19: towards controlling of a pandemic | Lancet, The | 2020 | 1,193 |
| 15 | Stretchable silicon nanoribbon electronics for skin prosthesis | Nature Communications | 2014 | 1,145 |
| 16 | Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery | Angewandte Chemie - International Edition | 2008 | 1,135 |
| 17 | Characterization of Two Types of Endothelial Progenitor Cells and Their Different Contributions to Neovasculogenesis | Arteriosclerosis, Thrombosis, and Vascular Biology | 2004 | 1,114 |
| 18 | Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms | Journal of the American College of Cardiology | 2011 | 1,058 |
| 19 | Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study | Lancet, The | 2016 | 962 |
| 20 | Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial | Lancet Oncology, The | 2016 | 950 |
| 21 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma | Hepatology International | 2010 | 944 |
| 22 | Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study | Lancet Oncology, The | 2020 | 923 |
| 23 | Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease | Digestive and Liver Disease | 2010 | 896 |
| 24 | Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial | Lancet, The | 2016 | 878 |
| 25 | Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial | Lancet, The | 2004 | 871 |
| 26 | Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria—A 10-Year Update | Radiology | 2014 | 870 |
| 27 | Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis | Lancet, The | 2012 | 854 |
| 28 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial | Lancet Oncology, The | 2010 | 852 |
| 29 | Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials | Lancet, The | 2017 | 840 |
| 30 | Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T1 Magnetic Resonance Imaging Contrast Agents | Journal of the American Chemical Society | 2011 | 835 |
| 31 | Predictive and Prognostic Impact of Epidermal Growth Factor Receptor Mutation in Non–Small-Cell Lung Cancer Patients Treated With Gefitinib | Journal of Clinical Oncology | 2005 | 736 |
| 32 | WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 1: Basic Principles and Terminology | Ultrasound in Medicine and Biology | 2015 | 718 |
| 33 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | Lancet Oncology, The | 2014 | 713 |
| 34 | Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation | Molecular Therapy | 2012 | 702 |
| 35 | Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial | Lancet Oncology, The | 2014 | 695 |
| 36 | Dabrafenib plus trametinib in patients with previously treated BRAFV600E-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial | Lancet Oncology, The | 2016 | 689 |
| 37 | Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA) | Annals of the Rheumatic Diseases | 2014 | 659 |
| 38 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012 | Ultrasound in Medicine and Biology | 2013 | 652 |
| 39 | Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study | Brain | 2019 | 636 |
| 40 | WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver | Ultrasound in Medicine and Biology | 2015 | 620 |
| 41 | Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study | Lancet Oncology, The | 2019 | 611 |
| 42 | Bloodstream Infections Caused by Antibiotic-Resistant Gram-Negative Bacilli: Risk Factors for Mortality and Impact of Inappropriate Initial Antimicrobial Therapy on Outcome | Antimicrobial Agents and Chemotherapy | 2005 | 597 |
| 43 | Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update | Journal of Stroke | 2017 | 584 |
| 44 | Osteoconduction at porous hydroxyapatite with various pore configurations | Biomaterials | 2000 | 575 |
| 45 | Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial | Lancet Oncology, The | 2009 | 571 |
| 46 | Transcutaneous ultrasound energy harvesting using capacitive triboelectric technology | Science | 2019 | 569 |
| 47 | Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells | Circulation | 2005 | 567 |
| 48 | Six-Month Versus 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents | Circulation | 2012 | 555 |
| 49 | Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity | Clinical Cancer Research | 2016 | 554 |
| 50 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
