| # | Title | Journal | Year | Citations |
|---|
| 1 | Whole genome sequencing of meticillin-resistant Staphylococcus aureus | Lancet, The | 2001 | 1,835 |
| 2 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial | Lancet Oncology, The | 2008 | 1,667 |
| 3 | Genetic Analysis of Human Norovirus Strains in Japan in 2016–2017 | Frontiers in Microbiology | 2018 | 1,397 |
| 4 | Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease | Nature Genetics | 2009 | 1,217 |
| 5 | Complete Genome Sequence of Enterohemorrhagic Eschelichia coli O157:H7 and Genomic Comparison with a Laboratory Strain K-12 | DNA Research | 2001 | 1,190 |
| 6 | Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis | Nature Biotechnology | 2003 | 1,108 |
| 7 | Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae | Lancet, The | 2003 | 928 |
| 8 | Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells | Stem Cells | 2008 | 921 |
| 9 | Hypofractionated Stereotactic Radiotherapy (HypoFXSRT) for Stage I Non-small Cell Lung Cancer: Updated Results of 257 Patients in a Japanese Multi-institutional Study | Journal of Thoracic Oncology | 2007 | 882 |
| 10 | Reevaluation of absolute luminescence quantum yields of standard solutions using a spectrometer with an integrating sphere and a back-thinned CCD detector | Physical Chemistry Chemical Physics | 2009 | 850 |
| 11 | Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma | Cancer | 2004 | 849 |
| 12 | Genome evolution in the allotetraploid frog Xenopus laevis | Nature | 2016 | 849 |
| 13 | Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen | Lancet Neurology, The | 2010 | 805 |
| 14 | Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 784 |
| 15 | Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes | DNA Research | 2007 | 760 |
| 16 | Altered pain perception and inflammatory response in mice lacking prostacyclin receptor | Nature | 1997 | 732 |
| 17 | Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial | Lancet, The | 2009 | 685 |
| 18 | Genomic basis for natural product biosynthetic diversity in the actinomycetes | Natural Product Reports | 2009 | 645 |
| 19 | Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy | Experimental Astronomy | 2011 | 640 |
| 20 | Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells | Free Radical Biology and Medicine | 2003 | 639 |
| 21 | A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization. | Journal of Antibiotics | 1977 | 631 |
| 22 | A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1 | Annals of Neurology | 2002 | 608 |
| 23 | Rivaroxaban vs. Warfarin in Japanese Patients With Atrial Fibrillation | Circulation Journal | 2012 | 589 |
| 24 | Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia | Nature Genetics | 2002 | 573 |
| 25 | Characterization of melanin-concentrating hormone in chum salmon pituitaries | Nature | 1983 | 563 |
| 26 | Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery? | International Journal of Radiation Oncology Biology Physics | 2011 | 561 |
| 27 | Updated classification of norovirus genogroups and genotypes | Journal of General Virology | 2019 | 535 |
| 28 | Genome Sequence of the Streptomycin-Producing MicroorganismStreptomyces griseusIFO 13350 | Journal of Bacteriology | 2008 | 534 |
| 29 | Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. | Journal of Antibiotics | 1991 | 517 |
| 30 | The 160-Kilobase Genome of the Bacterial Endosymbiont Carsonella | Science | 2006 | 501 |
| 31 | Anti-NMDA receptor encephalitis in Japan | Neurology | 2008 | 491 |
| 32 | The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2 | Biochemical and Biophysical Research Communications | 1990 | 477 |
| 33 | Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 455 |
| 34 | Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study | Journal of Clinical Oncology | 2020 | 450 |
| 35 | Ethnic Differences in the Relationship Between Insulin Sensitivity and Insulin Response | Diabetes Care | 2013 | 449 |
| 36 | Development and validation of MIX: comprehensive free software for meta-analysis of causal research data | BMC Medical Research Methodology | 2006 | 447 |
| 37 | JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ― | Circulation Journal | 2019 | 446 |
| 38 | Terpene synthases are widely distributed in bacteria | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 441 |
| 39 | Germline gain-of-function mutations in RAF1 cause Noonan syndrome | Nature Genetics | 2007 | 438 |
| 40 | Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease | Journal of Pediatrics | 2006 | 437 |
| 41 | Phase II Study of S-1, a Novel Oral Derivative of 5-Fluorouracil, in Advanced Gastric Cancer | Oncology | 2000 | 433 |
| 42 | Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: A Japanese Gynecologic Oncology Group study | Gynecologic Oncology | 2008 | 431 |
| 43 | A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 430 |
| 44 | Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial | Lancet Oncology, The | 2013 | 408 |
| 45 | Overlapping demyelinating syndromes and anti–N‐methyl‐D‐aspartate receptor encephalitis | Annals of Neurology | 2014 | 405 |
| 46 | Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells | Nature Immunology | 2006 | 399 |
| 47 | The Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensions | Molecular Psychiatry | 2006 | 392 |
| 48 | The Belle II Physics Book | Progress of Theoretical and Experimental Physics | 2019 | 384 |
| 49 | Tumour necrosis factor signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice | Gut | 2006 | 365 |
| 50 | Prevalence of Migraine in Japan | Cephalalgia | 1997 | 361 |
