| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 3 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 6 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 | Intensive Care Medicine | 2013 | 3,906 |
| 7 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 3,887 |
| 8 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 9 | Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis | New England Journal of Medicine | 2000 | 3,651 |
| 10 | ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology | Epilepsia | 2017 | 3,464 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 12 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study | Lancet, The | 2020 | 3,119 |
| 13 | Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis | Lancet Respiratory Medicine,the | 2019 | 1,866 |
| 14 | Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,855 |
| 15 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,671 |
| 16 | Grand challenges in global mental health | Nature | 2011 | 1,654 |
| 17 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 19 | The classification of glomerulonephritis in systemic lupus erythematosus revisited | Kidney International | 2004 | 1,272 |
| 20 | Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells | BioMed Research International | 2015 | 1,134 |
| 21 | Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity | Nanomedicine: Nanotechnology, Biology, and Medicine | 2016 | 1,082 |
| 22 | Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation | JAMA - Journal of the American Medical Association | 2010 | 1,024 |
| 23 | Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? | Ultrasound in Obstetrics and Gynecology | 2016 | 1,022 |
| 24 | Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome | New England Journal of Medicine | 1989 | 1,012 |
| 25 | The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 1,008 |
| 26 | Further Validation of Actigraphy for Sleep Studies | Sleep | 2003 | 1,003 |
| 27 | Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 983 |
| 28 | Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials | Lancet, The | 2021 | 979 |
| 29 | A Comparison of Symptom Prevalence in Far Advanced Cancer, AIDS, Heart Disease, Chronic Obstructive Pulmonary Disease and Renal Disease | Journal of Pain and Symptom Management | 2006 | 966 |
| 30 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 31 | The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update | Allergy: European Journal of Allergy and Clinical Immunology | 2014 | 912 |
| 32 | Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema | Ophthalmology | 2014 | 909 |
| 33 | Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial | Lancet, The | 2009 | 886 |
| 34 | Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2015 | 881 |
| 35 | A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI | Memorias Do Instituto Oswaldo Cruz | 2009 | 846 |
| 36 | TFOS DEWS II Management and Therapy Report | Ocular Surface | 2017 | 839 |
| 37 | The genome sequence of the plant pathogen Xylella fastidiosa | Nature | 2000 | 827 |
| 38 | Sepsis: a roadmap for future research | Lancet Infectious Diseases, The | 2015 | 827 |
| 39 | Validation of the alcohol, smoking and substance involvement screening test (ASSIST) | Addiction | 2008 | 825 |
| 40 | Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study | Lancet, The | 2005 | 787 |
| 41 | A review of optical coherence tomography angiography (OCTA) | International Journal of Retina and Vitreous | 2015 | 770 |
| 42 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Europace | 2018 | 767 |
| 43 | Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians | JAMA Pediatrics | 2017 | 746 |
| 44 | Nanotoxicity of Graphene and Graphene Oxide | Chemical Research in Toxicology | 2014 | 729 |
| 45 | Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma | Cancer Cell | 2017 | 716 |
| 46 | International Consensus Document (ICON): Common Variable Immunodeficiency Disorders | Journal of Allergy and Clinical Immunology: in Practice | 2016 | 669 |
| 47 | Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma | Cancer Discovery | 2017 | 637 |
| 48 | Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions | Endocrine Reviews | 2019 | 611 |
| 49 | Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM) | Endocrine Reviews | 2013 | 606 |
| 50 | Typical and Atypical EnteropathogenicEscherichia coli | Emerging Infectious Diseases | 2002 | 586 |
