| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 2 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies | Epilepsia | 2010 | 3,400 |
| 3 | IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 | Diabetes Research and Clinical Practice | 2022 | 2,873 |
| 4 | Spinal and Supraspinal Factors in Human Muscle Fatigue | Physiological Reviews | 2001 | 2,716 |
| 5 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 6 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 2,165 |
| 7 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 8 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy | Nature Genetics | 2009 | 1,808 |
| 9 | Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial | Lancet, The | 2011 | 1,629 |
| 10 | Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 1,571 |
| 11 | Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis | American Journal of Human Genetics | 1998 | 1,512 |
| 12 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 13 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 14 | Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2017 | 1,376 |
| 15 | Coronaviruses — drug discovery and therapeutic options | Nature Reviews Drug Discovery | 2016 | 1,365 |
| 16 | Activating Smoothened mutations in sporadic basal-cell carcinoma | Nature | 1998 | 1,209 |
| 17 | Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations | Lancet Respiratory Medicine,the | 2020 | 1,177 |
| 18 | The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Report from the Standardisation Committee of the International Children’s Continence Society | Journal of Urology | 2006 | 1,148 |
| 19 | A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques | Journal of Urology | 1999 | 1,135 |
| 20 | Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home | New England Journal of Medicine | 1996 | 1,108 |
| 21 | Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome | Clinical and Experimental Immunology | 2004 | 1,084 |
| 22 | Myogenic potentials generated by a click-evoked vestibulocollic reflex. | Journal of Neurology, Neurosurgery and Psychiatry | 1994 | 1,052 |
| 23 | Middle East respiratory syndrome | Lancet, The | 2015 | 1,033 |
| 24 | Genetic mechanisms of critical illness in COVID-19 | Nature | 2021 | 1,014 |
| 25 | Rapid Clearance of Fetal DNA from Maternal Plasma | American Journal of Human Genetics | 1999 | 1,006 |
| 26 | Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions | Science | 2003 | 1,004 |
| 27 | Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening | Gut | 2009 | 999 |
| 28 | Cognitive deficits in depression: Possible implications for functional neuropathology | British Journal of Psychiatry | 2001 | 998 |
| 29 | A Systematic Review on Ankle Injury and Ankle Sprain in Sports | Sports Medicine | 2007 | 996 |
| 30 | A variant in CDKAL1 influences insulin response and risk of type 2 diabetes | Nature Genetics | 2007 | 966 |
| 31 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 32 | Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome | Lancet, The | 2003 | 956 |
| 33 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 34 | Family caregivers of people with dementia | Dialogues in Clinical Neuroscience | 2009 | 920 |
| 35 | Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus | Science Translational Medicine | 2010 | 878 |
| 36 | Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial | Lancet, The | 2012 | 856 |
| 37 | Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial | Lancet, The | 2004 | 854 |
| 38 | Variants conferring risk of atrial fibrillation on chromosome 4q25 | Nature | 2007 | 853 |
| 39 | Use of convalescent plasma therapy in SARS patients in Hong Kong | European Journal of Clinical Microbiology and Infectious Diseases | 2005 | 838 |
| 40 | Low-Glycemic Index Diets in the Management of Diabetes: A meta-analysis of randomized controlled trials | Diabetes Care | 2003 | 826 |
| 41 | Meta-Analysis of Psychosocial Interventions for Caregivers of People with Dementia | Journal of the American Geriatrics Society | 2003 | 813 |
| 42 | Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture | Gut | 1998 | 812 |
| 43 | Prospective evaluation of patients refused admission to an intensive care unit: triage, futility and outcome | Intensive Care Medicine | 2001 | 788 |
| 44 | Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships | International Journal of Radiation Oncology Biology Physics | 1982 | 777 |
| 45 | The metabolic syndrome in children and adolescents | Lancet, The | 2007 | 776 |
| 46 | Detection and Characterization of Placental MicroRNAs in Maternal Plasma | Clinical Chemistry | 2008 | 775 |
| 47 | Peritoneal Dialysis-Related Infections Recommendations: 2010 Update | Peritoneal Dialysis International | 2010 | 770 |
| 48 | Acute kidney injury: an increasing global concern | Lancet, The | 2013 | 752 |
| 49 | Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis | Annals of Neurology | 2011 | 751 |
| 50 | ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment | Peritoneal Dialysis International | 2016 | 745 |
