| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Antithrombotic Therapy for VTE Disease | Chest | 2016 | 4,060 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores | Nature Genetics | 2009 | 1,977 |
| 5 | The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide | Cephalalgia | 2007 | 1,911 |
| 6 | The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies. | Journal of Abnormal Psychology | 2017 | 1,804 |
| 7 | Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science | 2020 | 1,749 |
| 8 | Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor | Journal of Neuroscience | 2001 | 1,563 |
| 9 | Demyelination increases radial diffusivity in corpus callosum of mouse brain | NeuroImage | 2005 | 1,482 |
| 10 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 11 | Lymphokine Control of In Vivo Immunoglobulin Isotype Selection | Annual Review of Immunology | 1990 | 1,299 |
| 12 | The B7 and CD28 receptor families | Trends in Immunology | 1994 | 1,279 |
| 13 | Public responses to the novel 2019 coronavirus (2019‐nCoV) in Japan: Mental health consequences and target populations | Psychiatry and Clinical Neurosciences | 2020 | 1,194 |
| 14 | Mechanisms of Anterior Cruciate Ligament Injury | Orthopedics | 2000 | 1,176 |
| 15 | p53: a frequent target for genetic abnormalities in lung cancer | Science | 1989 | 1,158 |
| 16 | Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome | Nature | 1990 | 1,156 |
| 17 | Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 1,123 |
| 18 | A Novel Human Opsin in the Inner Retina | Journal of Neuroscience | 2000 | 1,063 |
| 19 | Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2 | Journal of Immunology | 2000 | 1,058 |
| 20 | PONDR-FIT: A meta-predictor of intrinsically disordered amino acids | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2010 | 993 |
| 21 | Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400 | Clinical Neurophysiology | 2009 | 934 |
| 22 | Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis | Science | 2022 | 892 |
| 23 | Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1 | Science | 1999 | 879 |
| 24 | Abnormalities in structure and expression of the human retinoblastoma gene in SCLC | Science | 1988 | 870 |
| 25 | Common symptoms in ambulatory care: Incidence, evaluation, therapy, and outcome | American Journal of Medicine | 1989 | 861 |
| 26 | Human aminopeptidase N is a receptor for human coronavirus 229E | Nature | 1992 | 843 |
| 27 | Melanopsin: An opsin in melanophores, brain, and eye | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 836 |
| 28 | Virtual Reality Simulation for the Operating Room | Annals of Surgery | 2005 | 831 |
| 29 | Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical ComorbiditiesResults From the Cardiovascular Health Study | Archives of Internal Medicine | 2002 | 812 |
| 30 | Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation | Science | 2002 | 802 |
| 31 | A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome | New England Journal of Medicine | 2011 | 800 |
| 32 | T Cell-Independent Antigens Type 2 | Annual Review of Immunology | 1995 | 778 |
| 33 | Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting | Science | 2002 | 768 |
| 34 | The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation | Immunological Reviews | 1988 | 754 |
| 35 | TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages | Nature Immunology | 2002 | 753 |
| 36 | Developing questionnaires for educational research: AMEE Guide No. 87 | Medical Teacher | 2014 | 736 |
| 37 | Genome Sequence and Comparative Analysis of the Solvent-Producing Bacterium Clostridium acetobutylicum | Journal of Bacteriology | 2001 | 725 |
| 38 | Tat trans-activates the human immunodeficiency virus through a nascent RNA target | Cell | 1989 | 714 |
| 39 | Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults | Circulation | 2005 | 712 |
| 40 | Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature | Journal of Clinical Microbiology | 2012 | 710 |
| 41 | Genetic analysis of the human malaria parasite Plasmodium falciparum | Science | 1987 | 709 |
| 42 | The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy | Acta Neuropathologica | 2016 | 708 |
| 43 | Barrett's esophagus | Gastroenterology | 1987 | 691 |
| 44 | Changes in Medical Errors after Implementation of a Handoff Program | New England Journal of Medicine | 2014 | 685 |
| 45 | Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study | Headache | 2008 | 683 |
| 46 | Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis | Journal of Biological Chemistry | 2002 | 682 |
| 47 | How phenomenology can help us learn from the experiences of others | Perspectives on Medical Education | 2022 | 677 |
| 48 | Frontal lobe injuries, violence, and aggression | Neurology | 1996 | 676 |
| 49 | Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment | Archives of Family Medicine | 1994 | 671 |
| 50 | Predictors of patient satisfaction | Social Science and Medicine | 2001 | 664 |
