| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease | Cell | 2017 | 4,081 |
| 3 | Restoring function in exhausted CD8 T cells during chronic viral infection | Nature | 2006 | 3,471 |
| 4 | Understanding the tumor immune microenvironment (TIME) for effective therapy | Nature Medicine | 2018 | 3,421 |
| 5 | Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling | Cell | 2009 | 3,319 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 7 | The complex language of chromatin regulation during transcription | Nature | 2007 | 2,432 |
| 8 | The Microprocessor complex mediates the genesis of microRNAs | Nature | 2004 | 2,406 |
| 9 | PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression | Nature | 2006 | 2,380 |
| 10 | Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards | Nature Communications | 2016 | 2,076 |
| 11 | Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions | Nature | 2005 | 1,870 |
| 12 | Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response | Nature Medicine | 2006 | 1,865 |
| 13 | Integrins and other cell adhesion molecules | FASEB Journal | 1990 | 1,842 |
| 14 | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Nature | 2018 | 1,836 |
| 15 | TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing | Nature | 2005 | 1,799 |
| 16 | Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints | Nature | 2006 | 1,777 |
| 17 | Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection | Nature Immunology | 2009 | 1,754 |
| 18 | Involvement of the bcl-2 gene in human follicular lymphoma | Science | 1985 | 1,727 |
| 19 | Long Noncoding RNAs with Enhancer-like Function in Human Cells | Cell | 2010 | 1,664 |
| 20 | Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation | Science | 1984 | 1,624 |
| 21 | Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation | Science | 2013 | 1,595 |
| 22 | The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment | Trends in Immunology | 2016 | 1,507 |
| 23 | Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide | Nature Immunology | 2001 | 1,486 |
| 24 | Cancer as an evolutionary and ecological process | Nature Reviews Cancer | 2006 | 1,470 |
| 25 | Acetylation of Histones and Transcription-Related Factors | Microbiology and Molecular Biology Reviews | 2000 | 1,466 |
| 26 | An operational definition of epigenetics: Figure 1. | Genes and Development | 2009 | 1,457 |
| 27 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 28 | Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing | Cell | 2005 | 1,365 |
| 29 | Myeloid-Derived Suppressor Cells | Cancer Immunology Research | 2017 | 1,345 |
| 30 | Activation of microglial cells by β-amyloid protein and interferon-γ | Nature | 1995 | 1,312 |
| 31 | The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection | Nature Immunology | 2007 | 1,286 |
| 32 | Myeloid-derived suppressor cells coming of age | Nature Immunology | 2018 | 1,285 |
| 33 | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,206 |
| 34 | A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas | Cancer Research | 2005 | 1,200 |
| 35 | Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage | Nature | 1986 | 1,188 |
| 36 | Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K | Cancer Cell | 2010 | 1,139 |
| 37 | SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins | Genes and Development | 2002 | 1,074 |
| 38 | Histone modifications in transcriptional regulation | Current Opinion in Genetics and Development | 2002 | 1,071 |
| 39 | A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth | Cell | 2010 | 1,052 |
| 40 | Functions and Regulation of RNA Editing by ADAR Deaminases | Annual Review of Biochemistry | 2010 | 1,028 |
| 41 | The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining | Science | 1985 | 955 |
| 42 | Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. | Journal of Experimental Medicine | 1991 | 953 |
| 43 | High-throughput oncogene mutation profiling in human cancer | Nature Genetics | 2007 | 927 |
| 44 | The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis | Nature Cell Biology | 2008 | 924 |
| 45 | Molecular cloning of a new transforming gene from a chemically transformed human cell line | Nature | 1984 | 923 |
| 46 | Conjugated linoleic acid and atherosclerosis in rabbits | Atherosclerosis | 1994 | 918 |
| 47 | Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues | Journal of Virology | 2004 | 900 |
| 48 | Redefining Chronic Viral Infection | Cell | 2009 | 876 |
| 49 | Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma | Nature Genetics | 1993 | 869 |
| 50 | New Nomenclature for Chromatin-Modifying Enzymes | Cell | 2007 | 849 |
