| # | Title | Journal | Year | Citations |
|---|
| 1 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | BMJ, The | 2021 | 26,066 |
| 2 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene | Science | 1987 | 10,804 |
| 3 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2013 | 7,792 |
| 4 | Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction | New England Journal of Medicine | 1998 | 6,163 |
| 5 | Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. | Journal of Clinical Oncology | 1997 | 5,294 |
| 6 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp | Diabetes Care | 1999 | 4,832 |
| 7 | Correspondence of the brain's functional architecture during activation and rest | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 4,636 |
| 8 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | Systematic Reviews | 2021 | 3,624 |
| 9 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | International Journal of Surgery | 2021 | 3,487 |
| 10 | PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews | BMJ, The | 2021 | 3,413 |
| 11 | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Nature | 2009 | 3,191 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 13 | Automated Talairach Atlas labels for functional brain mapping | Human Brain Mapping | 2000 | 3,089 |
| 14 | Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis | New England Journal of Medicine | 2002 | 3,048 |
| 15 | Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy | New England Journal of Medicine | 2006 | 2,714 |
| 16 | International Study of the Prevalence and Outcomes of Infection in Intensive Care Units | JAMA - Journal of the American Medical Association | 2009 | 2,682 |
| 17 | Is the CVI an acceptable indicator of content validity? Appraisal and recommendations | Research in Nursing and Health | 2007 | 2,587 |
| 18 | Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events | New England Journal of Medicine | 2006 | 2,582 |
| 19 | Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America | Clinical Infectious Diseases | 2008 | 2,432 |
| 20 | Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease | New England Journal of Medicine | 2010 | 2,359 |
| 21 | Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes | New England Journal of Medicine | 2013 | 2,294 |
| 22 | AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer | New England Journal of Medicine | 2014 | 2,233 |
| 23 | Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer | Cell | 1993 | 2,195 |
| 24 | Prevalence of Prostate Cancer among Men with a Prostate-Specific Antigen Level ≤4.0 ng per Milliliter | New England Journal of Medicine | 2004 | 2,174 |
| 25 | Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome | Circulation | 2000 | 2,113 |
| 26 | Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness | American Journal of Psychiatry | 1999 | 2,051 |
| 27 | Collaborative Care Management of Late-Life Depression in the Primary Care Setting | JAMA - Journal of the American Medical Association | 2002 | 2,031 |
| 28 | A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM) | Philosophical Transactions of the Royal Society B: Biological Sciences | 2001 | 1,959 |
| 29 | The Metabolic Syndrome: Time for a Critical Appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes | Diabetes Care | 2005 | 1,936 |
| 30 | Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection | New England Journal of Medicine | 2013 | 1,605 |
| 31 | Traumatic glenohumeral bone defects and their relationship to failure of arthroscopic Bankart repairs | Arthroscopy - Journal of Arthroscopic and Related Surgery | 2000 | 1,604 |
| 32 | A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis | New England Journal of Medicine | 2006 | 1,584 |
| 33 | Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria | Science | 2005 | 1,576 |
| 34 | European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection | Public Health Nutrition | 2002 | 1,539 |
| 35 | The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA | Cell | 1984 | 1,459 |
| 36 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 37 | 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer | New England Journal of Medicine | 2016 | 1,427 |
| 38 | Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip | Journal of the American Academy of Dermatology | 1992 | 1,394 |
| 39 | Senolytics improve physical function and increase lifespan in old age | Nature Medicine | 2018 | 1,384 |
| 40 | Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-year results of the Look AHEAD trial | Diabetes Care | 2007 | 1,369 |
| 41 | Limbic-cortical dysregulation: a proposed model of depression | Journal of Neuropsychiatry and Clinical Neurosciences | 1997 | 1,350 |
| 42 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | PLoS Medicine | 2021 | 1,340 |
| 43 | Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,337 |
| 44 | NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older | Diabetes | 2003 | 1,332 |
| 45 | Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template | Human Brain Mapping | 2007 | 1,284 |
| 46 | A compendium of RNA-binding motifs for decoding gene regulation | Nature | 2013 | 1,281 |
| 47 | Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis | Nature | 1992 | 1,259 |
| 48 | Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial | Lancet Oncology, The | 2010 | 1,252 |
| 49 | Association of Risk-Reducing Surgery in <emph type="ital">BRCA1</emph> or <emph type="ital">BRCA2</emph> Mutation Carriers With Cancer Risk and Mortality | JAMA - Journal of the American Medical Association | 2010 | 1,241 |
| 50 | High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors | Arthritis and Rheumatism | 2001 | 1,219 |
