| # | Title | Journal | Year | Citations |
|---|
| 1 | BioGRID: a general repository for interaction datasets | Nucleic Acids Research | 2006 | 3,407 |
| 2 | Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group | Journal of Clinical Oncology | 2007 | 3,396 |
| 3 | The 2015 World Health Organization Classification of Lung Tumors | Journal of Thoracic Oncology | 2015 | 3,313 |
| 4 | Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study | Lancet Infectious Diseases, The | 2020 | 2,704 |
| 5 | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma | Annals of Neurology | 2007 | 2,166 |
| 6 | The Biochemistry of P-Glycoprotein-Mediated Multidrug Resistance | Annual Review of Biochemistry | 1989 | 2,051 |
| 7 | Drug Resistance and the Solid Tumor Microenvironment | Journal of the National Cancer Institute | 2007 | 1,795 |
| 8 | 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer | Clinical Infectious Diseases | 2002 | 1,738 |
| 9 | A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer | New England Journal of Medicine | 2003 | 1,723 |
| 10 | MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia | Nature Genetics | 2002 | 1,720 |
| 11 | X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy | Nature Genetics | 2001 | 1,648 |
| 12 | Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection | Cell | 1993 | 1,640 |
| 13 | Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial | Lancet, The | 2002 | 1,617 |
| 14 | Stereotactic body radiation therapy: The report of AAPM Task Group 101 | Medical Physics | 2010 | 1,616 |
| 15 | Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. | Journal of Clinical Oncology | 1996 | 1,466 |
| 16 | Consistent Detection of 2019 Novel Coronavirus in Saliva | Clinical Infectious Diseases | 2020 | 1,423 |
| 17 | Micafungin versus Fluconazole for Prophylaxis against Invasive Fungal Infections during Neutropenia in Patients Undergoing Hematopoietic Stem Cell Transplantation | Clinical Infectious Diseases | 2004 | 1,248 |
| 18 | Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial | Lancet, The | 2020 | 1,244 |
| 19 | A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 | Nature | 2008 | 1,169 |
| 20 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial | Lancet, The | 2005 | 1,105 |
| 21 | A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer | Nature Medicine | 2000 | 1,037 |
| 22 | Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,032 |
| 23 | Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study | Lancet Oncology, The | 2011 | 1,028 |
| 24 | Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun | Nature | 1994 | 1,016 |
| 25 | Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study | Journal of Clinical Oncology | 2008 | 987 |
| 26 | Lung pathology of fatal severe acute respiratory syndrome | Lancet, The | 2003 | 979 |
| 27 | Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study | Lancet Public Health, The | 2020 | 977 |
| 28 | Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis | Lancet, The | 2006 | 967 |
| 29 | Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines | Science | 1983 | 959 |
| 30 | Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans | Science | 2020 | 947 |
| 31 | Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies | Nature | 1985 | 899 |
| 32 | External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study | Lancet Oncology, The | 2010 | 830 |
| 33 | Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines | Nature | 1985 | 801 |
| 34 | Hypoxia signalling through mTOR and the unfolded protein response in cancer | Nature Reviews Cancer | 2008 | 787 |
| 35 | Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome | American Journal of Obstetrics and Gynecology | 2004 | 770 |
| 36 | Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS) | Lancet, The | 2003 | 768 |
| 37 | Exploring the role of cancer stem cells in radioresistance | Nature Reviews Cancer | 2008 | 766 |
| 38 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 39 | A genome-wide search for quantitative trait loci underlying asthma | Nature | 1996 | 750 |
| 40 | Re-emergence of fatal human influenza A subtype H5N1 disease | Lancet, The | 2004 | 743 |
| 41 | Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 | Nature | 1994 | 729 |
| 42 | Mutations in SUFU predispose to medulloblastoma | Nature Genetics | 2002 | 722 |
| 43 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial | Lancet Oncology, The | 2013 | 710 |
| 44 | Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy | Nature Medicine | 2011 | 705 |
| 45 | Advanced pancreatic carcinoma: current treatment and future challenges | Nature Reviews Clinical Oncology | 2010 | 704 |
| 46 | Guidance document on delivery, treatment planning, and clinical implementation of IMRT: Report of the IMRT subcommittee of the AAPM radiation therapy committee | Medical Physics | 2003 | 693 |
| 47 | Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study | Lancet Microbe, The | 2020 | 683 |
| 48 | Mesenchymal Stromal Cells: New Directions | Cell Stem Cell | 2012 | 679 |
| 49 | Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance | Nature | 1986 | 677 |
| 50 | Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 | Journal of Clinical Oncology | 2008 | 674 |
