| # | Title | Journal | Year | Citations |
|---|
| 1 | Epidemiology of adult fractures: A review | Injury | 2006 | 2,507 |
| 2 | Chronic Kidney Disease | Lancet, The | 2017 | 2,274 |
| 3 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial | Lancet, The | 2008 | 1,759 |
| 4 | Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics” | Clinical Nutrition | 2010 | 1,360 |
| 5 | Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region | Journal of General Virology | 1993 | 1,340 |
| 6 | Management of spontaneous pneumothorax: British Thoracic Society pleural disease guideline 2010 | Thorax | 2010 | 1,047 |
| 7 | Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2013 | 1,017 |
| 8 | Genetic mechanisms of critical illness in COVID-19 | Nature | 2021 | 1,014 |
| 9 | A proposed system for the nomenclature of hepatitis C viral genotypes | Hepatology | 1994 | 962 |
| 10 | Resolving the fibrotic niche of human liver cirrhosis at single-cell level | Nature | 2019 | 946 |
| 11 | Human primary liver cancer–derived organoid cultures for disease modeling and drug screening | Nature Medicine | 2017 | 905 |
| 12 | 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial | Lancet, The | 2014 | 804 |
| 13 | Benefits and Risks of the Combination of Clopidogrel and Aspirin in Patients Undergoing Surgical Revascularization for Non–ST-Elevation Acute Coronary Syndrome | Circulation | 2004 | 778 |
| 14 | Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies | British Journal of Cancer | 2006 | 759 |
| 15 | Diabetes and cognitive dysfunction | Lancet, The | 2012 | 722 |
| 16 | Cardiac morbidity and mortality related to orthotopic liver transplantation | Liver Transplantation | 2004 | 682 |
| 17 | Predicting dissatisfaction following total knee replacement | Journal of Bone and Joint Surgery: British Volume | 2010 | 680 |
| 18 | The epidemiology of musculoskeletal tendinous and ligamentous injuries | Injury | 2008 | 643 |
| 19 | Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis | American Journal of Clinical Nutrition | 2006 | 633 |
| 20 | British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE | Thorax | 2015 | 631 |
| 21 | Fractures of the clavicle in the adult. Epidemiology and classification | Journal of Bone and Joint Surgery: British Volume | 1998 | 596 |
| 22 | Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema | New England Journal of Medicine | 2008 | 586 |
| 23 | Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method | Journal of Clinical Microbiology | 2010 | 585 |
| 24 | Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial | Blood | 2007 | 584 |
| 25 | Depression after stroke and lesion location: a systematic review | Lancet, The | 2000 | 579 |
| 26 | Consensus guidelines for enhanced recovery after gastrectomy | British Journal of Surgery | 2014 | 564 |
| 27 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers | Clinical Chemistry | 2008 | 539 |
| 28 | Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines | World Journal of Emergency Surgery | 2020 | 533 |
| 29 | Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies | Diabetes Care | 1997 | 527 |
| 30 | Frequency of Severe Hypoglycemia Requiring Emergency Treatment in Type 1 and Type 2 Diabetes: A population-based study of health service resource use | Diabetes Care | 2003 | 519 |
| 31 | UK guidelines on the management of variceal haemorrhage in cirrhotic patients | Gut | 2015 | 518 |
| 32 | Impact of age on management and outcome of acute coronary syndrome: Observations from the global registry of acute coronary events (GRACE) | American Heart Journal | 2005 | 514 |
| 33 | Randomized Trial of Diaspirin Cross-linked Hemoglobin Solution as an Alternative to Blood Transfusion after Cardiac Surgery | Anesthesiology | 2000 | 498 |
| 34 | Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C | Lancet, The | 1997 | 488 |
| 35 | British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) | Thorax | 2017 | 488 |
| 36 | Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial | Gut | 2003 | 485 |
| 37 | Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease | Hepatology | 1994 | 481 |
| 38 | Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis | PLoS Medicine | 2018 | 481 |
| 39 | Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study | Lancet, The | 2021 | 479 |
| 40 | Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis | British Journal of Surgery | 2006 | 472 |
| 41 | Management of acute coronary syndromes. Variations in practice and outcome. Findings from the Global Registry of Acute Coronary Events (GRACE) | European Heart Journal | 2002 | 467 |
| 42 | Management of women who test positive for high-risk types of human papillomavirus: the HART study | Lancet, The | 2003 | 467 |
| 43 | Circulating microRNAs as potential markers of human drug-induced liver injury | Hepatology | 2011 | 464 |
| 44 | Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV | Blood | 2007 | 461 |
| 45 | European Hernia Society guidelines on the closure of abdominal wall incisions | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2015 | 460 |
| 46 | Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey | Journal of Clinical Microbiology | 1994 | 457 |
| 47 | Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study | Diabetic Medicine | 2005 | 452 |
| 48 | Epidemiology of fractures in 15,000 adults: the influence of age and gender | Journal of Bone and Joint Surgery: British Volume | 1998 | 451 |
| 49 | Acute compartment syndrome. Who is at risk? | Journal of Bone and Joint Surgery: British Volume | 2000 | 449 |
| 50 | Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity | Journal of General Virology | 1993 | 444 |
